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Gene Review

CENPE  -  centromere protein E, 312kDa

Homo sapiens

Synonyms: CENP-E, Centromere protein E, Centromere-associated protein E, KIF10, Kinesin-related protein CENPE, ...
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Analytical, diagnostic and therapeutic context of CENPE


  1. Mitotic HeLa cells contain a CENP-E-associated minus end-directed microtubule motor. Thrower, D.A., Jordan, M.A., Schaar, B.T., Yen, T.J., Wilson, L. EMBO J. (1995) [Pubmed]
  2. CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment. Wood, K.W., Sakowicz, R., Goldstein, L.S., Cleveland, D.W. Cell (1997) [Pubmed]
  3. CENP-E is a putative kinetochore motor that accumulates just before mitosis. Yen, T.J., Li, G., Schaar, B.T., Szilak, I., Cleveland, D.W. Nature (1992) [Pubmed]
  4. Chromosomal localization of the genes encoding the kinetochore proteins CENPE and CENPF to human chromosomes 4q24-->q25 and 1q32-->q41, respectively, by fluorescence in situ hybridization. Testa, J.R., Zhou, J.Y., Bell, D.W., Yen, T.J. Genomics (1994) [Pubmed]
  5. Silencing mitosin induces misaligned chromosomes, premature chromosome decondensation before anaphase onset, and mitotic cell death. Yang, Z., Guo, J., Chen, Q., Ding, C., Du, J., Zhu, X. Mol. Cell. Biol. (2005) [Pubmed]
  6. Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules. Ashar, H.R., James, L., Gray, K., Carr, D., Black, S., Armstrong, L., Bishop, W.R., Kirschmeier, P. J. Biol. Chem. (2000) [Pubmed]
  7. Cleavage furrows formed between centrosomes lacking an intervening spindle and chromosomes contain microtubule bundles, INCENP, and CHO1 but not CENP-E. Savoian, M.S., Earnshaw, W.C., Khodjakov, A., Rieder, C.L. Mol. Biol. Cell (1999) [Pubmed]
  8. Neocentromere formation in a stable ring 1p32-p36.1 chromosome. Slater, H.R., Nouri, S., Earle, E., Lo, A.W., Hale, L.G., Choo, K.H. J. Med. Genet. (1999) [Pubmed]
  9. Gene silencing of CENP-E by small interfering RNA in HeLa cells leads to missegregation of chromosomes after a mitotic delay. Tanudji, M., Shoemaker, J., L'Italien, L., Russell, L., Chin, G., Schebye, X.M. Mol. Biol. Cell (2004) [Pubmed]
  10. Specific regulation of CENP-E and kinetochores during meiosis I/meiosis II transition in pig oocytes. Lee, J., Miyano, T., Dai, Y., Wooding, P., Yen, T.J., Moor, R.M. Mol. Reprod. Dev. (2000) [Pubmed]
  11. Kinesin-like protein CENP-E is upregulated in rheumatoid synovial fibroblasts. Kullmann, F., Judex, M., Ballhorn, W., Jüsten, H.P., Wessinghage, D., Welsh, J., Yen, T.J., Lang, B., Hittle, J.C., McClelland, M., Gay, S., Schölmerich, J., Müller-Ladner, U. Arthritis Res. (1999) [Pubmed]
  12. Septin 7 interacts with centromere-associated protein E and is required for its kinetochore localization. Zhu, M., Wang, F., Yan, F., Yao, P.Y., Du, J., Gao, X., Wang, X., Wu, Q., Ward, T., Li, J., Kioko, S., Hu, R., Xie, W., Ding, X., Yao, X. J. Biol. Chem. (2008) [Pubmed]
  13. Elevating the level of Cdc34/Ubc3 ubiquitin-conjugating enzyme in mitosis inhibits association of CENP-E with kinetochores and blocks the metaphase alignment of chromosomes. Topper, L.M., Bastians, H., Ruderman, J.V., Gorbsky, G.J. J. Cell Biol. (2001) [Pubmed]
  14. Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC. Chan, G.K., Jablonski, S.A., Sudakin, V., Hittle, J.C., Yen, T.J. J. Cell Biol. (1999) [Pubmed]
  15. Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation. Kurasawa, Y., Earnshaw, W.C., Mochizuki, Y., Dohmae, N., Todokoro, K. EMBO J. (2004) [Pubmed]
  16. RNAi knockdown of human kinetochore protein CENP-H. Orthaus, S., Ohndorf, S., Diekmann, S. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  17. The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosis. Jablonski, S.A., Chan, G.K., Cooke, C.A., Earnshaw, W.C., Yen, T.J. Chromosoma (1998) [Pubmed]
  18. Anaphase onset does not require the microtubule-dependent depletion of kinetochore and centromere-binding proteins. Canman, J.C., Sharma, N., Straight, A., Shannon, K.B., Fang, G., Salmon, E.D. J. Cell. Sci. (2002) [Pubmed]
  19. Crystallization and preliminary crystallographic analysis of the motor domain of human kinetochore-associated protein CENP-E using an automated crystallization procedure. Garcia-Saez, I., Blot, D., Kahn, R., Kozielski, F. Acta Crystallogr. D Biol. Crystallogr. (2004) [Pubmed]
  20. CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint. Yao, X., Abrieu, A., Zheng, Y., Sullivan, K.F., Cleveland, D.W. Nat. Cell Biol. (2000) [Pubmed]
  21. Cyclin-like accumulation and loss of the putative kinetochore motor CENP-E results from coupling continuous synthesis with specific degradation at the end of mitosis. Brown, K.D., Coulson, R.M., Yen, T.J., Cleveland, D.W. J. Cell Biol. (1994) [Pubmed]
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