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Gene Review

Itm2a  -  integral membrane protein 2A

Mus musculus

Synonyms: AW108051, Bricd2a, E25, Integral membrane protein 2A, Itm2, ...
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High impact information on Itm2a

  • The mouse E25 gene locus (Itm2) was mapped to the X chromosome [1].
  • MMP-13 expression was restricted to chondrocytes of the lower zone of hypertrophic cartilage also expressing collagen type X. In osteoblasts involved in endochondral and intramembranous ossification Itm2a was not present [2].
  • In areas undergoing endochondral ossification Itm2a expression was found in chondrocytes of the resting and the proliferating zones [2].
  • During embryonic development expression of Itm2a and ALP was detectable at midgestation (11.5 days postcoitum [dpc]) and increased up to 16.5 dpc [2].
  • The Itm2a gene contains six exons and five introns [3].

Biological context of Itm2a


Anatomical context of Itm2a

  • Targeting via the anti-fibronectin antibody and anti-endothelial antiserum provided maximal quantitative binding of glucose oxidase to endothelial cells, while the conjugates with MoAb E25 and MoAb E78 monoclonal antibodies provided less effective binding [5].

Associations of Itm2a with chemical compounds

  • Though the quantitative binding of MoAb E25-conjugated glucose oxidase was minimal comparing to other conjugates, targeting via MoAb E25 produced the maximal cytotoxic effect as well as targeting via polyclonal antiserum [5].

Regulatory relationships of Itm2a


  1. Isolation of markers for chondro-osteogenic differentiation using cDNA library subtraction. Molecular cloning and characterization of a gene belonging to a novel multigene family of integral membrane proteins. Deleersnijder, W., Hong, G., Cortvrindt, R., Poirier, C., Tylzanowski, P., Pittois, K., Van Marck, E., Merregaert, J. J. Biol. Chem. (1996) [Pubmed]
  2. Collagenase-3 (MMP-13) and integral membrane protein 2a (Itm2a) are marker genes of chondrogenic/osteoblastic cells in bone formation: sequential temporal, and spatial expression of Itm2a, alkaline phosphatase, MMP-13, and osteocalcin in the mouse. Tuckermann, J.P., Pittois, K., Partridge, N.C., Merregaert, J., Angel, P. J. Bone Miner. Res. (2000) [Pubmed]
  3. Genomic organization and chromosomal localization of the Itm2a gene. Pittois, K., Wauters, J., Bossuyt, P., Deleersnijder, W., Merregaert, J. Mamm. Genome (1999) [Pubmed]
  4. In vitro studies on Itm2a reveal its involvement in early stages of the chondrogenic differentiation pathway. Van den Plas, D., Merregaert, J. Biol. Cell (2004) [Pubmed]
  5. Cytotoxicity of glucose oxidase conjugated with antibodies to target cells: killing efficiency depends on the conjugate internalization. Muzykantov, V.R., Trubetskaya, O.V., Puchnina, E.A., Sakharov, D.V., Domogatsky, S.P. Biochim. Biophys. Acta (1990) [Pubmed]
  6. Constitutive overexpression of the integral membrane protein Itm2A enhances myogenic differentiation of C2C12 cells. Van den Plas, D., Merregaert, J. Cell Biol. Int. (2004) [Pubmed]
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