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Gene Review

Dnm1  -  dynamin 1

Mus musculus

Synonyms: AI838169, Dnm, Dynamin-1, Ftfl, Kiaa4093, ...
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Disease relevance of Dnm1


Psychiatry related information on Dnm1


High impact information on Dnm1


Biological context of Dnm1


Anatomical context of Dnm1

  • Overexpression of dynamin increased osteoclast bone resorbing activity and migration, whereas overexpression of dynK44A decreased osteoclast resorption and migration [11].
  • Although expression of mutant dynamin in macrophages inhibited particle internalization, it had no effect on the production of inflammatory mediators elicited by particle binding [10].
  • Therefore, the goal of this study was to test whether dynamin associates with caveolae via a direct binding to the caveolin 1 (Cav1) protein [16].
  • We showed that overexpression of Fzo1A/B (rat) proteins involved in mitochondrial fusion, or silencing of Dnm1 (rat)/Drp1 (human) (a mitochondrial fission protein), increased elongated mitochondria in healthy cells [17].
  • Therefore, dynamin may provide the trigger and actin may provide the force for movement into the cytosol [18].

Associations of Dnm1 with chemical compounds

  • Endophilin B1, like endophilins A, binds to palmitoyl-CoA, exhibits lysophosphatidic acid acyl transferase activity, and interacts with dynamin, amphiphysins 1 and 2, and huntingtin [19].
  • Furthermore, phosphotyrosine-containing proteins in the dynamin immunocomplexes were observed to be reactive with anticaveolin-1 antibodies [20].
  • The binding of dynamin to SH3 domain-containing proteins may therefore be important for formation of the protein complex required for the endocytic processing of activated tyrosine kinase receptors [21].
  • CTB entry in the Cav1-/- MEFs was predominantly clathrin and dynamin independent but relatively cholesterol dependent [22].
  • Deletion from amphiphysin of its central proline-rich stretch dramatically potentiated its effect on dynamin, possibly by relieving an inhibitory intramolecular interaction [23].

Physical interactions of Dnm1


Enzymatic interactions of Dnm1

  • Neither dynamin nor the synapsins were phosphorylated by Src, suggesting that the interaction of these proteins serves to direct the kinase activity of Src toward other proteins in the vesicle population [25].

Co-localisations of Dnm1

  • In quiescent cells, dynamin II is evenly distributed in the cytoplasm and colocalizes with syndecan-4 near the nucleus [27].

Regulatory relationships of Dnm1

  • The dynamin II expression level was higher when co-expressed with myosin II in Ras transformed NIH3T3 cells than in normal NIH3T3 cells [26].
  • In contrast, expression of K44A/dynamin partially inhibited insulin-stimulated Shc tyrosine phosphorylation and activation of the mitogen-activated protein kinases ERK1 and -2 [2].
  • In conclusion, these results suggest that dynamin II may be largely expressed and closely associated with Grb2-mediated signaling in Ras transformed cells [28].
  • Furthermore, dynamin inhibited the activity of both purified recombinant and immunoprecipitated PI 3-kinase [29].
  • Pretreatment with the PKC inhibitor bisindolylmaleimide II (Bis II), with sucrose (0.4 m), or through the expression of a dominant-negative form of dynamin prevents PMA-induced GLT-1 internalization and cluster formation [30].

Other interactions of Dnm1


Analytical, diagnostic and therapeutic context of Dnm1


  1. The dynamin-related mouse mitochondrial GTPase OPA1 alters the structure of the mitochondrial inner membrane when exogenously introduced into COS-7 cells. Misaka, T., Murate, M., Fujimoto, K., Kubo, Y. Neurosci. Res. (2006) [Pubmed]
  2. Inhibition of clathrin-mediated endocytosis selectively attenuates specific insulin receptor signal transduction pathways. Ceresa, B.P., Kao, A.W., Santeler, S.R., Pessin, J.E. Mol. Cell. Biol. (1998) [Pubmed]
  3. Caveolin-1 is a negative regulator of caveolae-mediated endocytosis to the endoplasmic reticulum. Le, P.U., Guay, G., Altschuler, Y., Nabi, I.R. J. Biol. Chem. (2002) [Pubmed]
  4. Early steps of polyomavirus entry into cells. Gilbert, J.M., Benjamin, T.L. J. Virol. (2000) [Pubmed]
  5. The avian retrovirus avian sarcoma/leukosis virus subtype A reaches the lipid mixing stage of fusion at neutral pH. Earp, L.J., Delos, S.E., Netter, R.C., Bates, P., White, J.M. J. Virol. (2003) [Pubmed]
  6. Beta-amyloid-induced dynamin 1 depletion in hippocampal neurons. A potential mechanism for early cognitive decline in Alzheimer disease. Kelly, B.L., Vassar, R., Ferreira, A. J. Biol. Chem. (2005) [Pubmed]
  7. Coupling between clathrin-coated-pit invagination, cortactin recruitment, and membrane scission observed in live cells. Merrifield, C.J., Perrais, D., Zenisek, D. Cell (2005) [Pubmed]
  8. Amphiphysin IIm, a novel amphiphysin II isoform, is required for macrophage phagocytosis. Gold, E.S., Morrissette, N.S., Underhill, D.M., Guo, J., Bassetti, M., Aderem, A. Immunity (2000) [Pubmed]
  9. Constitutive endocytosis and degradation of the pre-T cell receptor. Panigada, M., Porcellini, S., Barbier, E., Hoeflinger, S., Cazenave, P.A., Gu, H., Band, H., von Boehmer, H., Grassi, F. J. Exp. Med. (2002) [Pubmed]
  10. Dynamin 2 is required for phagocytosis in macrophages. Gold, E.S., Underhill, D.M., Morrissette, N.S., Guo, J., McNiven, M.A., Aderem, A. J. Exp. Med. (1999) [Pubmed]
  11. Dynamin forms a Src kinase-sensitive complex with Cbl and regulates podosomes and osteoclast activity. Bruzzaniti, A., Neff, L., Sanjay, A., Horne, W.C., De Camilli, P., Baron, R. Mol. Biol. Cell (2005) [Pubmed]
  12. Differential appearance of dynamin in constitutive and regulated exo-endocytosis: a single-cell multiplex RT-PCR study. Grabs, D., Bergmann, M. Cell Tissue Res. (2005) [Pubmed]
  13. Dynamin-2 regulates oxidized low-density lipoprotein-induced apoptosis of vascular smooth muscle cell. Kashiwakura, Y., Watanabe, M., Kusumi, N., Sumiyoshi, K., Nasu, Y., Yamada, H., Sawamura, T., Kumon, H., Takei, K., Daida, H. Circulation (2004) [Pubmed]
  14. Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase. Ezratty, E.J., Partridge, M.A., Gundersen, G.G. Nat. Cell Biol. (2005) [Pubmed]
  15. Characterization of the mouse dynamin I gene promoter and identification of sequences that direct expression in neuronal cells. Yoo, J., Lee, S.S., Jeong, M.J., Lee, K.I., Kwon, B.M., Kim, S.H., Park, Y.M., Han, M.Y. Biochem. J. (2000) [Pubmed]
  16. Caveolin-1 interacts directly with dynamin-2. Yao, Q., Chen, J., Cao, H., Orth, J.D., McCaffery, J.M., Stan, R.V., McNiven, M.A. J. Mol. Biol. (2005) [Pubmed]
  17. Fzo1, a protein involved in mitochondrial fusion, inhibits apoptosis. Sugioka, R., Shimizu, S., Tsujimoto, Y. J. Biol. Chem. (2004) [Pubmed]
  18. Imaging actin and dynamin recruitment during invagination of single clathrin-coated pits. Merrifield, C.J., Feldman, M.E., Wan, L., Almers, W. Nat. Cell Biol. (2002) [Pubmed]
  19. Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1. Modregger, J., Schmidt, A.A., Ritter, B., Huttner, W.B., Plomann, M. J. Biol. Chem. (2003) [Pubmed]
  20. The endocytosis-linked protein dynamin associates with caveolin-1 and is tyrosine phosphorylated in response to the activation of a noninternalizing epidermal growth factor receptor mutant. Kim, Y.N., Bertics, P.J. Endocrinology (2002) [Pubmed]
  21. Growth factor-induced binding of dynamin to signal transduction proteins involves sorting to distinct and separate proline-rich dynamin sequences. Scaife, R., Gout, I., Waterfield, M.D., Margolis, R.L. EMBO J. (1994) [Pubmed]
  22. Ultrastructural identification of uncoated caveolin-independent early endocytic vehicles. Kirkham, M., Fujita, A., Chadda, R., Nixon, S.J., Kurzchalia, T.V., Sharma, D.K., Pagano, R.E., Hancock, J.F., Mayor, S., Parton, R.G. J. Cell Biol. (2005) [Pubmed]
  23. The stimulatory action of amphiphysin on dynamin function is dependent on lipid bilayer curvature. Yoshida, Y., Kinuta, M., Abe, T., Liang, S., Araki, K., Cremona, O., Di Paolo, G., Moriyama, Y., Yasuda, T., De Camilli, P., Takei, K. EMBO J. (2004) [Pubmed]
  24. Mouse profilin 2 regulates endocytosis and competes with SH3 ligand binding to dynamin 1. Gareus, R., Di Nardo, A., Rybin, V., Witke, W. J. Biol. Chem. (2006) [Pubmed]
  25. Src interacts with dynamin and synapsin in neuronal cells. Foster-Barber, A., Bishop, J.M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  26. Increased association of dynamin II with myosin II in ras transformed NIH3T3 cells. Jeong, S.J., Kim, S.G., Yoo, J., Han, M.Y., Park, J.C., Kim, H.J., Kang, S.S., Choi, B.D., Jeong, M.J. Acta Biochim. Biophys. Sin. (Shanghai) (2006) [Pubmed]
  27. Dynamin II interacts with syndecan-4, a regulator of focal adhesion and stress-fiber formation. Yoo, J., Jeong, M.J., Cho, H.J., Oh, E.S., Han, M.Y. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  28. Dynamin II associates with Grb2 SH3 domain in Ras transformed NIH3T3 cells. Yoon, S.Y., Koh, W.S., Lee, M.K., Park, Y.M., Han, M.Y. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  29. Dynamin inhibits phosphatidylinositol 3-kinase in hematopoietic cells. Harrison-Findik, D., Misra, S., Jain, S.K., Keeler, M.L., Powell, K.A., Malladi, C.S., Varticovski, L., Robinson, P.J. Biochim. Biophys. Acta (2001) [Pubmed]
  30. Glutamate transporter cluster formation in astrocytic processes regulates glutamate uptake activity. Zhou, J., Sutherland, M.L. J. Neurosci. (2004) [Pubmed]
  31. Expression and localisation of dynamin and syntaxin during neural development and neuromuscular synapse formation. Noakes, P.G., Chin, D., Kim, S.S., Liang, S., Phillips, W.D. J. Comp. Neurol. (1999) [Pubmed]
  32. Assignment of the dynamin-1 gene (DNM1) to human chromosome 9q34 by fluorescence in situ hybridization and somatic cell hybrid analysis. Newman-Smith, E.D., Shurland, D.L., van der Bliek, A.M. Genomics (1997) [Pubmed]
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