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Gene Review

Kcnk1  -  potassium channel, subfamily K, member 1

Mus musculus

Synonyms: AI788889, Inward rectifying potassium channel protein TWIK-1, Potassium channel subfamily K member 1, TWIK-1
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High impact information on Kcnk1

  • TWIK-1, TREK-1 and TASK K+ channels comprise a class of pore-forming subunits with four membrane-spanning segments and two P domains [1].
  • The two-pore domain K(+) channel, TRESK (TWIK-related spinal cord K(+) channel) is activated in response to the calcium signal by the calcium/calmodulin-dependent protein phosphatase, calcineurin [2].
  • TWIK1 belongs to a family of K(+) channels involved in neuronal excitability and cell volume regulation [3].
  • Of these, TWIK-1 and TASK-1 were preferentially expressed in taste cells relative to surrounding nonsensory epithelium [4].
  • The twik gene (or KCNK1) has been mapped to chromosome 8, consistent with its localization to 1q42-43 in human [5].

Biological context of Kcnk1


Anatomical context of Kcnk1

  • TWIK-1 mRNA is expressed abundantly in brain and at lower levels in lung, kidney, and skeletal muscle [7].
  • We examined their expression in mouse vallate and foliate taste buds using RT-PCR, and detected TWIK-1 and -2, TREK-1 and -2, and TASK-1 [4].
  • However, the evidence for TWIK-related acid-sensitive potassium (TASK)-like conductances in inhibitory interneurons is less clear, and mRNA expression has suggested that TASK channels are expressed in only a subpopulation of interneurons [8].

Associations of Kcnk1 with chemical compounds

  • Acute pharmacologic blockade of the vasopressin V(2)-receptor revealed both an attenuated diuretic response and an attenuated internalization of aquaporin-2 in the inner medullary collecting duct in twik-1 -/- versus +/+ mice [9].

Other interactions of Kcnk1


  1. A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids. Fink, M., Lesage, F., Duprat, F., Heurteaux, C., Reyes, R., Fosset, M., Lazdunski, M. EMBO J. (1998) [Pubmed]
  2. Targeting of calcineurin to an NFAT-like docking site is required for the calcium-dependent activation of the background K+ channel, TRESK. Czirják, G., Enyedi, P. J. Biol. Chem. (2006) [Pubmed]
  3. ARF6-dependent interaction of the TWIK1 K+ channel with EFA6, a GDP/GTP exchange factor for ARF6. Decressac, S., Franco, M., Bendahhou, S., Warth, R., Knauer, S., Barhanin, J., Lazdunski, M., Lesage, F. EMBO Rep. (2004) [Pubmed]
  4. Acid-sensitive two-pore domain potassium (K2P) channels in mouse taste buds. Richter, T.A., Dvoryanchikov, G.A., Chaudhari, N., Roper, S.D. J. Neurophysiol. (2004) [Pubmed]
  5. Structure, chromosome localization, and tissue distribution of the mouse twik K+ channel gene. Arrighi, I., Lesage, F., Scimeca, J.C., Carle, G.F., Barhanin, J. FEBS Lett. (1998) [Pubmed]
  6. Cloning and functional expression of a novel cardiac two-pore background K+ channel (cTBAK-1). Kim, D., Fujita, A., Horio, Y., Kurachi, Y. Circ. Res. (1998) [Pubmed]
  7. The structure, function and distribution of the mouse TWIK-1 K+ channel. Lesage, F., Lauritzen, I., Duprat, F., Reyes, R., Fink, M., Heurteaux, C., Lazdunski, M. FEBS Lett. (1997) [Pubmed]
  8. TASK-like conductances are present within hippocampal CA1 stratum oriens interneuron subpopulations. Torborg, C.L., Berg, A.P., Jeffries, B.W., Bayliss, D.A., McBain, C.J. J. Neurosci. (2006) [Pubmed]
  9. Expression and insights on function of potassium channel TWIK-1 in mouse kidney. Nie, X., Arrighi, I., Kaissling, B., Pfaff, I., Mann, J., Barhanin, J., Vallon, V. Pflugers Arch. (2005) [Pubmed]
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