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Gene Review

Mcpt2  -  mast cell protease 2

Mus musculus

Synonyms: MMCP-2, Mast cell protease 2, Mcp-2, mMCP-2
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Disease relevance of Mcpt2


High impact information on Mcpt2

  • Cultured mast cells of WBB6F1(-)+/+ mice that expressed MMCP-2 mRNA were transplanted into the stomach wall of genetically mast-cell-deficient WBB6F1(-)W/Wv mice [2].
  • Mast cells that appeared in the mucosa expressed the MMCP-2 mRNA, but mast cells that appeared in the muscularis propria did not, indicating the adaptation of cultured mast cells into a new environment [2].
  • A significant amount of MMCP-2 mRNA was not expressed in the skin of all +/+, Wv/Wv and mi/mi mice [3].
  • After affinity purification, this antibody, anti-mMCP-2(56-71) IgG, reacted in SDS-PAGE/immunoblots against a 28-kDa protein in BMMCW+IL-10 that had the N-terminal amino acid sequence of mMCP-2 [4].
  • Reversible expression of mouse mast cell protease 2 mRNA and protein in cultured mast cells exposed to IL-10 [4].

Biological context of Mcpt2

  • DNA blot analysis using the full-length MMCP-2 cDNA indicated the existence of a family of highly related serine protease genes in the mouse genome [1].
  • The fact that the steady-state levels of mMCP-2 mRNA and protein in BMMC can both be reversibly altered by culturing these mast cells in the presence and absence of rIL-10 suggests that the phenotype of mast cells is not fixed [4].

Anatomical context of Mcpt2


Other interactions of Mcpt2

  • Moreover, we show that in the rat, the Mcpt8-family diversified relatively recently together with sequences related to the beta-chymase Mcpt2 [5].
  • The amino acid identity was of 74% with RMCP2, and of 76%, 65% and 90% with the mouse proteases MMCP1, MMCP2 and MMCP4, respectively [6].
  • They included four proteases (mouse mast cell protease 2, granzyme B, pepsinogen F and serine protease 1) and two metabolic enzymes (adenine phosphoribosyltransferase and fructose1,6-bisphosphatase) [7].


  1. Identification and molecular cloning of a novel mouse mucosal mast cell serine protease. Serafin, W.E., Reynolds, D.S., Rogelj, S., Lane, W.S., Conder, G.A., Johnson, S.S., Austen, K.F., Stevens, R.L. J. Biol. Chem. (1990) [Pubmed]
  2. Expression of mast-cell-specific proteases in tissues of mice studied by in situ hybridization. Jippo, T., Tsujino, K., Kim, H.M., Kim, D.K., Lee, Y.M., Nawa, Y., Kitamura, Y. Am. J. Pathol. (1997) [Pubmed]
  3. Deficient differentiation of mast cells in the skin of mi/mi mice. Usefulness of in situ hybridization for evaluation of mast cell phenotype. Kasugai, T., Oguri, K., Jippo-Kanemoto, T., Morimoto, M., Yamatodani, A., Yoshida, K., Ebi, Y., Isozaki, K., Tei, H., Tsujimura, T. Am. J. Pathol. (1993) [Pubmed]
  4. Reversible expression of mouse mast cell protease 2 mRNA and protein in cultured mast cells exposed to IL-10. Ghildyal, N., Friend, D.S., Nicodemus, C.F., Austen, K.F., Stevens, R.L. J. Immunol. (1993) [Pubmed]
  5. Rapid lineage-specific diversification of the mast cell chymase locus during mammalian evolution. Gallwitz, M., Hellman, L. Immunogenetics (2006) [Pubmed]
  6. Molecular cloning of rat mast cell protease 1 and development of specific probes for its gene transcript. Rouleau, A., Garbarg, M., Schwartz, J.C., Ruat, M. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  7. Search for oncogenic regulators in an autocrine tumor model using differential display PCR: identification of novel candidate genes including the calcium channel mtrp6. Buess, M., Engler, O., Hirsch, H.H., Moroni, C. Oncogene (1999) [Pubmed]
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