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Gene Review

Mcpt4  -  mast cell protease 4

Mus musculus

Synonyms: MMCP-4, MMCP-4A, MMCP-4B, MSMCP, Mast cell protease 4, ...
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Disease relevance of Mcpt4


High impact information on Mcpt4

  • To gain insight into the biological role of mast cell chymase we have generated a mouse strain with a targeted deletion in the gene for mast cell protease 4 (mMCP-4), the mouse chymase that has the closest relationship to the human chymase in terms of tissue localization and functional properties [4].
  • The inactivation of mMCP-4 did not affect the storage of other mast cell proteases and did not affect the number of mast cells or the mast cell morphology [4].
  • Further, a role for mMCP-4 in connective tissue remodeling was suggested by the inability of mMCP-4 null peritoneal cells to process endogenous fibronectin [4].
  • However, mMCP-4 inactivation resulted in complete loss of chymotryptic activity in the peritoneum and in ear tissue, indicating that mMCP-4 is the main source of stored chymotrypsin-like protease activity at these sites [4].
  • The mMCP-4 null cells showed markedly impaired ability to perform inactivating cleavages of thrombin, indicating a role for mMCP-4 in regulating the extravascular coagulation system [4].

Biological context of Mcpt4


Anatomical context of Mcpt4


Associations of Mcpt4 with chemical compounds


Other interactions of Mcpt4

  • Biochemical and immunological characterization of multiple glycoforms of mouse mast cell protease 1: comparison with an isolated murine serosal mast cell protease (MMCP-4) [13].
  • Evidence for at least two additional, but not so recent, exchanges was found in the 3' regions of the MMCP-4 and MMCP-L genes and in the 5' regions of the genes for MMCP-1 and MMCP-2 [14].
  • We compared the regulation mechanisms of another chymase, MMCP-4, with those of MMCP-5 and MMCP-6 [5].
  • MMCP-4 mRNA was not expressed in normal mouse intestine or in interleukin 3-dependent bone marrow-derived mast cells, which can serve as precursors to both MMC and CTMC [6].
  • The expression of MMCP-2, MMCP-4, and MMCP-6 was much greater in IC-2G559 and IC-2V814 cells than in the original IC-2 cells [15].

Analytical, diagnostic and therapeutic context of Mcpt4


  1. Cloning and structural analysis of MMCP-1, MMCP-4 and MMCP-5, three mouse mast cell-specific serine proteases. Huang, R.Y., Blom, T., Hellman, L. Eur. J. Immunol. (1991) [Pubmed]
  2. Mast cell chymase induces expression of chemokines for neutrophils in eosinophilic EoL-1 cells and mouse peritonitis eosinophils. Terakawa, M., Tomimori, Y., Goto, M., Fukuda, Y. Eur. J. Pharmacol. (2006) [Pubmed]
  3. Chymase inhibitor improves dermatitis in NC/Nga mice. Watanabe, N., Tomimori, Y., Saito, K., Miura, K., Wada, A., Tsudzuki, M., Fukuda, Y. Int. Arch. Allergy Immunol. (2002) [Pubmed]
  4. The chymase, mouse mast cell protease 4, constitutes the major chymotrypsin-like activity in peritoneum and ear tissue. A role for mouse mast cell protease 4 in thrombin regulation and fibronectin turnover. Tchougounova, E., Pejler, G., Abrink, M. J. Exp. Med. (2003) [Pubmed]
  5. Deficient transcription of mouse mast cell protease 4 gene in mutant mice of mi/mi genotype. Jippo, T., Lee, Y.M., Katsu, Y., Tsujino, K., Morii, E., Kim, D.K., Kim, H.M., Kitamura, Y. Blood (1999) [Pubmed]
  6. Cloning of the cDNA and gene for mouse mast cell protease 4. Demonstration of its late transcription in mast cell subclasses and analysis of its homology to subclass-specific neutral proteases of the mouse and rat. Serafin, W.E., Sullivan, T.P., Conder, G.A., Ebrahimi, A., Marcham, P., Johnson, S.S., Austen, K.F., Reynolds, D.S. J. Biol. Chem. (1991) [Pubmed]
  7. Intraepithelial infiltration by mast cells with both connective tissue-type and mucosal-type characteristics in gut, trachea, and kidneys of IL-9 transgenic mice. Godfraind, C., Louahed, J., Faulkner, H., Vink, A., Warnier, G., Grencis, R., Renauld, J.C. J. Immunol. (1998) [Pubmed]
  8. Differential expression of secretory granule proteases in mouse mast cells exposed to interleukin 3 and c-kit ligand. Gurish, M.F., Ghildyal, N., McNeil, H.P., Austen, K.F., Gillis, S., Stevens, R.L. J. Exp. Med. (1992) [Pubmed]
  9. Expression of mast-cell-specific proteases in tissues of mice studied by in situ hybridization. Jippo, T., Tsujino, K., Kim, H.M., Kim, D.K., Lee, Y.M., Nawa, Y., Kitamura, Y. Am. J. Pathol. (1997) [Pubmed]
  10. Cooperation between mast cell carboxypeptidase A and the chymase mouse mast cell protease 4 in the formation and degradation of angiotensin II. Lundequist, A., Tchougounova, E., Abrink, M., Pejler, G. J. Biol. Chem. (2004) [Pubmed]
  11. A key role for mast cell chymase in the activation of pro-matrix metalloprotease-9 and pro-matrix metalloprotease-2. Tchougounova, E., Lundequist, A., Fajardo, I., Winberg, J.O., Abrink, M., Pejler, G. J. Biol. Chem. (2005) [Pubmed]
  12. Purification and characterization of myonase from X-chromosome linked muscular dystrophic mouse skeletal muscle. Hori, S., Ohtani, S., Hori, C., Nokihara, K. J. Biochem. (1998) [Pubmed]
  13. Biochemical and immunological characterization of multiple glycoforms of mouse mast cell protease 1: comparison with an isolated murine serosal mast cell protease (MMCP-4). Newlands, G.F., Knox, D.P., Pirie-Shepherd, S.R., Miller, H.R. Biochem. J. (1993) [Pubmed]
  14. Genes for mast-cell serine protease and their molecular evolution. Huang, R., Hellman, L. Immunogenetics (1994) [Pubmed]
  15. Transforming and differentiation-inducing potential of constitutively activated c-kit mutant genes in the IC-2 murine interleukin-3-dependent mast cell line. Hashimoto, K., Tsujimura, T., Moriyama, Y., Yamatodani, A., Kimura, M., Tohya, K., Morimoto, M., Kitayama, H., Kanakura, Y., Kitamura, Y. Am. J. Pathol. (1996) [Pubmed]
  16. Thrombin is inactivated by mast cell secretory granule chymase. Pejler, G., Karlström, A. J. Biol. Chem. (1993) [Pubmed]
  17. Isoform-selective upregulation of mast cell chymase in the development of skin fibrosis in scleroderma model mice. Kakizoe, E., Shiota, N., Tanabe, Y., Shimoura, K., Kobayashi, Y., Okunishi, H. J. Invest. Dermatol. (2001) [Pubmed]
  18. Myonase is localized in skeletal muscle myofibrils. Hori, S., Yamada, M., Ohtani, S., Hori, C., Yokomizo, T., Webb, T., Shimokawa, T. J. Biochem. (2002) [Pubmed]
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