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Gene Review

lmn-1  -  Protein LMN-1

Caenorhabditis elegans

 
 
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High impact information on lmn-1

 

Biological context of lmn-1

  • The expression, lamin-dependent localization and RNAi depletion phenotype for emerin in C. elegans [6].
  • These results suggest that lamin cleavage probably is not essential for apoptosis in C. elegans [7].
  • Essential roles for Caenorhabditis elegans lamin gene in nuclear organization, cell cycle progression, and spatial organization of nuclear pore complexes [5].
  • Eliminating the single lamin protein caused cell death as visualized by characteristic changes in nuclear architecture including condensation of chromatin, clustering of NPCs, membrane blebbing, and the presence of vesicles inside the nucleus [8].
  • Down-regulation of Ce-lamin causes embryonic lethality [9].
 

Anatomical context of lmn-1

 

Physical interactions of lmn-1

 

Other interactions of lmn-1

 

Analytical, diagnostic and therapeutic context of lmn-1

References

  1. MAN1 and emerin have overlapping function(s) essential for chromosome segregation and cell division in Caenorhabditis elegans. Liu, J., Lee, K.K., Segura-Totten, M., Neufeld, E., Wilson, K.L., Gruenbaum, Y. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. unc-83 encodes a novel component of the nuclear envelope and is essential for proper nuclear migration. Starr, D.A., Hermann, G.J., Malone, C.J., Fixsen, W., Priess, J.R., Horvitz, H.R., Han, M. Development (2001) [Pubmed]
  3. A role for Caenorhabditis elegans importin IMA-2 in germ line and embryonic mitosis. Geles, K.G., Johnson, J.J., Jong, S., Adam, S.A. Mol. Biol. Cell (2002) [Pubmed]
  4. C. elegans nuclear envelope proteins emerin, MAN1, lamin, and nucleoporins reveal unique timing of nuclear envelope breakdown during mitosis. Lee, K.K., Gruenbaum, Y., Spann, P., Liu, J., Wilson, K.L. Mol. Biol. Cell (2000) [Pubmed]
  5. Essential roles for Caenorhabditis elegans lamin gene in nuclear organization, cell cycle progression, and spatial organization of nuclear pore complexes. Liu, J., Rolef Ben-Shahar, T., Riemer, D., Treinin, M., Spann, P., Weber, K., Fire, A., Gruenbaum, Y. Mol. Biol. Cell (2000) [Pubmed]
  6. The expression, lamin-dependent localization and RNAi depletion phenotype for emerin in C. elegans. Gruenbaum, Y., Lee, K.K., Liu, J., Cohen, M., Wilson, K.L. J. Cell. Sci. (2002) [Pubmed]
  7. Fate of the nuclear lamina during Caenorhabditis elegans apoptosis. Tzur, Y.B., Hersh, B.M., Horvitz, H.R., Gruenbaum, Y. J. Struct. Biol. (2002) [Pubmed]
  8. Transmission electron microscope studies of the nuclear envelope in Caenorhabditis elegans embryos. Cohen, M., Tzur, Y.B., Neufeld, E., Feinstein, N., Delannoy, M.R., Wilson, K.L., Gruenbaum, Y. J. Struct. Biol. (2002) [Pubmed]
  9. A lamin-dependent pathway that regulates nuclear organization, cell cycle progression and germ cell development. Margalit, A., Liu, J., Fridkin, A., Wilson, K.L., Gruenbaum, Y. Novartis Found. Symp. (2005) [Pubmed]
  10. The single nuclear lamin of Caenorhabditis elegans forms in vitro stable intermediate filaments and paracrystals with a reduced axial periodicity. Karabinos, A., Schünemann, J., Meyer, M., Aebi, U., Weber, K. J. Mol. Biol. (2003) [Pubmed]
  11. Nuclear titin interacts with A- and B-type lamins in vitro and in vivo. Zastrow, M.S., Flaherty, D.B., Benian, G.M., Wilson, K.L. J. Cell. Sci. (2006) [Pubmed]
  12. Molecular characterization and expression patterns of a B-type nuclear lamin during sea urchin embryogenesis. Holy, J., Wessel, G., Berg, L., Gregg, R.G., Schatten, G. Dev. Biol. (1995) [Pubmed]
  13. Lamin-dependent localization of UNC-84, a protein required for nuclear migration in Caenorhabditis elegans. Lee, K.K., Starr, D., Cohen, M., Liu, J., Han, M., Wilson, K.L., Gruenbaum, Y. Mol. Biol. Cell (2002) [Pubmed]
 
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