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Gene Review:

AGER - advanced glycosylation end product...

Homo sapiens

Synonyms: Advanced glycosylation end product-specific receptor, RAGE, Receptor for advanced glycosylation end products

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Disease relevance of AGER

BACKGROUND: Receptors for advanced glycation endproducts (AGE-R) mediate AGE turnover, but can also trigger inflammatory genes that promote diabetic tissue injury and diabetic complications (DC) [1].
Polymorphisms in the advanced glycosylation end product-specific receptor gene and risk of incident myocardial infarction or ischemic stroke [2].

Psychiatry related information on AGER

In these weekly confrontations, grief and rage articulate intense contestations regarding the politics of peace as well as the politics of gender in Israel. Rage and grief unravel two drastically different visions of transcending national vulnerabilities and two disparate constructions of gender identity [3].

High impact information on AGER

Additional cross-linking studies on human peripheral monocytes revealed an AGE-R protein of identical size to that on RAW 264.7 cells, suggesting the relatively highly conserved nature of this molecule.(ABSTRACT TRUNCATED AT 250 WORDS)[4]
Macrophages internalize and degrade proteins modified by advanced glycosylation end products (AGEs) via a specific receptor (AGE-R) [4].
Localization of the human gene for advanced glycosylation end product-specific receptor (AGER) to chromosome 6p21.3 [5].
AGE-receptor expression, MAP-kinase signal transduction and apoptosis were analyzed using PCR, Western blotting and flow cytometry [6].
The John F. Maher Recipient Lecture 2004: Rage in the peritoneum [7].

Associations of AGER with chemical compounds

METHODS: 48 children with TS between ages 7 and 17 years consecutively presenting with rage attacks completed the Rage Attacks Screen and Questionnaire [8].
The use of MDMA as an adjunct to spiritual pursuit among New Ager seekers is examined [9].

Analytical, diagnostic and therapeutic context of AGER

Decreased aggressivity was reflected in a 29% reduction on Measure of Aggression, Violence, and Rage in Children [MAVRIC] ratings (p < or = 0.02) and in 86% less time in seclusion or physical restraints (p < or = 0.02) [10].

References

Presence of diabetic complications in type 1 diabetic patients correlates with low expression of mononuclear cell AGE-receptor-1 and elevated serum AGE. He, C.J., Koschinsky, T., Buenting, C., Vlassara, H. Mol. Med. (2001) [Pubmed]
Polymorphisms in the advanced glycosylation end product-specific receptor gene and risk of incident myocardial infarction or ischemic stroke. Zee, R.Y., Romero, J.R., Gould, J.L., Ricupero, D.A., Ridker, P.M. Stroke (2006) [Pubmed]
Grief and rage: collective emotions in the politics of peace and the politics of gender in Israel. Gabriel, A.H. Culture, medicine and psychiatry. (1992) [Pubmed]
Isolation of surface binding protein specific for advanced glycosylation end products from mouse macrophage-derived cell line RAW 264.7. Radoff, S., Cerami, A., Vlassara, H. Diabetes (1990) [Pubmed]
Localization of the human gene for advanced glycosylation end product-specific receptor (AGER) to chromosome 6p21.3. Vissing, H., Aagaard, L., Tommerup, N., Boel, E. Genomics (1994) [Pubmed]
Depression of progenitor cell function by advanced glycation endproducts (AGEs): potential relevance for impaired angiogenesis in advanced age and diabetes. Scheubel, R.J., Kahrstedt, S., Weber, H., Holtz, J., Friedrich, I., Borgermann, J., Silber, R.E., Simm, A. Exp. Gerontol. (2006) [Pubmed]
The John F. Maher Recipient Lecture 2004: Rage in the peritoneum. De Vriese, A.S. Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis. (2005) [Pubmed]
Clinical phenomenology of episodic rage in children with Tourette syndrome. Budman, C.L., Rockmore, L., Stokes, J., Sossin, M. Journal of psychosomatic research. (2003) [Pubmed]
New age seekers: MDMA use as an adjunct to spiritual pursuit. Watson, L., Beck, J. Journal of psychoactive drugs. (1991) [Pubmed]
Buspirone treatment of psychiatrically hospitalized prepubertal children with symptoms of anxiety and moderately severe aggression. Pfeffer, C.R., Jiang, H., Domeshek, L.J. Journal of child and adolescent psychopharmacology. (1997) [Pubmed]

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