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Chemical Compound Review

Flurazole     benzyl2-chloro-4- (trifluoromethyl)-1,3...

Synonyms: Screen, SureCN23033, AG-G-87293, AC1L3MNG, CTK8F4182, ...
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Disease relevance of Flurazole


Psychiatry related information on Flurazole

  • DATA SOURCES--Computerized searches of MEDLINE (1966 through 1990) were done using two search strategies: (1) (Patient Compliance OR Adhere* OR Dropout*) AND (Appointment*) AND (Screen* OR Follow* OR Refer*); and (2) (Patient Compliance OR Adhere* OR Dropout*) AND (Attend* OR Screen*) OR (Appointment*) [6].
  • MAIN OUTCOME MEASURES: The World Health Organization Psychosis Screen and the Schedules for Clinical Assessment in Neuropsychiatry to classify, blind to ethnicity, all DSM-IV psychotic syndromes and the subclasses of schizophrenia, other nonaffective disorders, affective disorders, and substance-induced psychosis [7].
  • The South Oaks Gambling Screen is a 20-item questionnaire based on DSM-III criteria for pathological gambling [8].
  • CONCLUSIONS: Screen-detected patients generally do not experience much difficulty with their condition in the first few years, but early and intensive treatment can influence patients' psychological outcomes, leading to relatively more anxiety and less self-efficacy in the 1st year after diagnosis but not necessarily improving self-care [9].
  • METHODS: Forty-five Vietnam combat veterans with PTSD but without a primary psychotic disorder diagnosis underwent a Structured Clinical Interview for DSM-III-R with Psychotic Screen, and the Clinician Administered PTSD Scale (CAPS) [10].

High impact information on Flurazole

  • The Anticancer Drug Screen of the National Cancer Institute uses 60 cell lines to identify new agents [11].
  • Generation of a drug resistance profile by quantitation of mdr-1/P-glycoprotein in the cell lines of the National Cancer Institute Anticancer Drug Screen [11].
  • Analysis of the National Cancer Institute Human Tumor Cell Line Anti-Cancer Drug Screen data using the COMPARE algorithm to detect similarities in the pattern of compound action to flavopiridol, a known inhibitor of cyclin-dependent kinases (CDKs), has suggested several possible novel CDK inhibitors [12].
  • We used human tumor cell lines from the National Cancer Institute's In Vitro Antineoplastic Drug Screen to assess whether sensitivity to any of the approximately 45,000 compounds tested previously correlated with the presence of a ras oncogene [13].
  • Thus, six of seven colon carcinoma cell lines from the NCI Anticancer Drug Screen are functionally Chk2-deficient in response to replication-mediated DNA double strand breaks [14].

Chemical compound and disease context of Flurazole

  • The interactions between 9-aminocamptothecin (9AC) and cisplatin (CDDP) have been studied in the IGROV-1 human ovarian cancer cell line used in the National Cancer Institute Drug Discovery Anticancer Screen. One-h simultaneous treatment with 9AC and CDDP produced synergistic cytotoxicity [15].
  • Performance of a Commercial Immunoglobulin M Antibody Capture Assay Using Analyte-Specific Reagents To Screen for Interfering Factors during a West Nile Virus Epidemic Season in Nebraska [16].
  • The primary outcome measures were participation by and interest of community organizations in dissemination of materials from Screen for Life: National Colorectal Cancer Action Campaign, a national campaign to promote colorectal cancer education and screening [17].

Biological context of Flurazole

  • Analysis of the 7 human colon carcinoma cell lines of the NCI Anticancer Drug Screen showed that defects in replicon elongation and G2 breakthrough capability correlate with sensitivity to CPT [18].
  • The 50% inhibitory concentrations (IC50) in these cell lines ranged from 0.019 +/- 0.013 to 11.4 +/- 0.55 microM and were comparable with values obtained with renal cell lines in the NCI Drug Screen panel [19].
  • From an analysis comparing the p53 genotype of the 60 cell lines of the National Cancer Institute (NCI) Drug Screen with the cytotoxicity profiles for the 16 putative renal compounds, 13 compounds were classified as likely to be indifferent to p53 status [19].
  • After 4 weeks, the prism-treated group performed significantly better than controls on the following: (1) Motor Free Visual Perception Test; (2) Line Bisection Task; (3) Line Cancellation Task; (4) Harrington Flocks Visual Field Screener; and (5) Tangent Screen Examination [20].
  • In Screen B germline clonal analysis of 581 larval and pupal mutations distributed throughout the entire length of the X chromosome was performed [21].

Anatomical context of Flurazole


Associations of Flurazole with other chemical compounds


Gene context of Flurazole


Analytical, diagnostic and therapeutic context of Flurazole

  • The incidence of moderate-severe cognitive dysfunction by the High Sensitivity Cognitive Screen decreased in patients from 16% (on chemotherapy) to 4.4% and 3.8% and in controls from 5% to 3.6% and 0% at 1 and 2 years, respectively [36].
  • Consecutive patients were randomly assigned to be asked a single question about mood, to fill out the 20-item Center for Epidemiologic Studies Depression Screen, or to usual care [37].
  • OBJECTIVE: Our goal was to compare the associations of items from the Level II Nutrition Screen (LII) and the Probability of Repeated Admissions (P(ra)) questionnaire with the outcome of hospitalization [38].
  • DESIGN: This cross-sectional study explored relations between weight status and nutritional risk, which was determined on the basis of the Level II Screen, overall diet quality, nutrient intakes, and plasma biomarkers [39].
  • The Columbia Suicide Screen: validity and reliability of a screen for youth suicide and depression [40].


  1. A Genome-Wide Screen Reveals Functional Gene Clusters in the Cancer Genome and Identifies EphA2 as a Mitogen in Glioblastoma. Liu, F., Park, P.J., Lai, W., Maher, E., Chakravarti, A., Durso, L., Jiang, X., Yu, Y., Brosius, A., Thomas, M., Chin, L., Brennan, C., Depinho, R.A., Kohane, I., Carroll, R.S., Black, P.M., Johnson, M.D. Cancer Res. (2006) [Pubmed]
  2. A Phage Display Screen and Binding Studies with Acetylated Low Density Lipoprotein Provide Evidence for the Importance of the Scavenger Receptor Cysteine-rich (SRCR) Domain in the Ligand-binding Function of MARCO. Chen, Y., Sankala, M., Ojala, J.R., Sun, Y., Tuuttila, A., Isenman, D.E., Tryggvason, K., Pikkarainen, T. J. Biol. Chem. (2006) [Pubmed]
  3. A Sensitized Screen of N-ethyl-N-nitrosourea-Mutagenized Mice Identifies Dominant Mutants Predisposed to Diabetic Nephropathy. Tchekneva, E.E., Rinchik, E.M., Polosukhina, D., Davis, L.S., Kadkina, V., Mohamed, Y., Dunn, S.R., Sharma, K., Qi, Z., Fogo, A.B., Breyer, M.D. J. Am. Soc. Nephrol. (2007) [Pubmed]
  4. Expression of beta-tubulin isotypes in human ovarian carcinoma xenografts and in a sub-panel of human cancer cell lines from the NCI-Anticancer Drug Screen: correlation with sensitivity to microtubule active agents. Nicoletti, M.I., Valoti, G., Giannakakou, P., Zhan, Z., Kim, J.H., Lucchini, V., Landoni, F., Mayo, J.G., Giavazzi, R., Fojo, T. Clin. Cancer Res. (2001) [Pubmed]
  5. Identifying stroke in the field. Prospective validation of the Los Angeles prehospital stroke screen (LAPSS). Kidwell, C.S., Starkman, S., Eckstein, M., Weems, K., Saver, J.L. Stroke (2000) [Pubmed]
  6. An overview of interventions to improve compliance with appointment keeping for medical services. Macharia, W.M., Leon, G., Rowe, B.H., Stephenson, B.J., Haynes, R.B. JAMA (1992) [Pubmed]
  7. Heterogeneity in incidence rates of schizophrenia and other psychotic syndromes: findings from the 3-center AeSOP study. Kirkbride, J.B., Fearon, P., Morgan, C., Dazzan, P., Morgan, K., Tarrant, J., Lloyd, T., Holloway, J., Hutchinson, G., Leff, J.P., Mallett, R.M., Harrison, G.L., Murray, R.M., Jones, P.B. Arch. Gen. Psychiatry (2006) [Pubmed]
  8. The South Oaks Gambling Screen (SOGS): a new instrument for the identification of pathological gamblers. Lesieur, H.R., Blume, S.B. The American journal of psychiatry. (1987) [Pubmed]
  9. Psychological Outcomes of Patients With Screen-Detected Type 2 Diabetes: The influence of time since diagnosis and treatment intensity. Thoolen, B.J., de Ridder, D.T., Bensing, J.M., Gorter, K.J., Rutten, G.E. Diabetes Care (2006) [Pubmed]
  10. Psychotic features and illness severity in combat veterans with chronic posttraumatic stress disorder. Hamner, M.B., Frueh, B.C., Ulmer, H.G., Arana, G.W. Biol. Psychiatry (1999) [Pubmed]
  11. Generation of a drug resistance profile by quantitation of mdr-1/P-glycoprotein in the cell lines of the National Cancer Institute Anticancer Drug Screen. Alvarez, M., Paull, K., Monks, A., Hose, C., Lee, J.S., Weinstein, J., Grever, M., Bates, S., Fojo, T. J. Clin. Invest. (1995) [Pubmed]
  12. Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases. Zaharevitz, D.W., Gussio, R., Leost, M., Senderowicz, A.M., Lahusen, T., Kunick, C., Meijer, L., Sausville, E.A. Cancer Res. (1999) [Pubmed]
  13. Enhanced sensitivity to 1-beta-D-arabinofuranosylcytosine and topoisomerase II inhibitors in tumor cell lines harboring activated ras oncogenes. Koo, H.M., Monks, A., Mikheev, A., Rubinstein, L.V., Gray-Goodrich, M., McWilliams, M.J., Alvord, W.G., Oie, H.K., Gazdar, A.F., Paull, K.D., Zarbl, H., Vande Woude, G.F. Cancer Res. (1996) [Pubmed]
  14. Defective Mre11-dependent Activation of Chk2 by Ataxia Telangiectasia Mutated in Colorectal Carcinoma Cells in Response to Replication-dependent DNA Double Strand Breaks. Takemura, H., Rao, V.A., Sordet, O., Furuta, T., Miao, Z.H., Meng, L., Zhang, H., Pommier, Y. J. Biol. Chem. (2006) [Pubmed]
  15. Potentiation of cisplatin cytotoxicity by 9-aminocamptothecin. Goldwasser, F., Valenti, M., Torres, R., Kohn, K.W., Pommier, Y. Clin. Cancer Res. (1996) [Pubmed]
  16. Performance of a Commercial Immunoglobulin M Antibody Capture Assay Using Analyte-Specific Reagents To Screen for Interfering Factors during a West Nile Virus Epidemic Season in Nebraska. Sambol, A.R., Hinrichs, S.H., Hogrefe, W.R., Schweitzer, B.K. Clin. Vaccine Immunol. (2007) [Pubmed]
  17. The impact of cancer coalitions on the dissemination of colorectal cancer materials to community organizations in rural Appalachia. Ward, A.J., Coffey Kluhsman, B., Lengerich, E.J., Piccinin, A.M. Preventing chronic disease [electronic resource]. (2006) [Pubmed]
  18. Correlations between S and G2 arrest and the cytotoxicity of camptothecin in human colon carcinoma cells. Goldwasser, F., Shimizu, T., Jackman, J., Hoki, Y., O'Connor, P.M., Kohn, K.W., Pommier, Y. Cancer Res. (1996) [Pubmed]
  19. Screening for and identification of novel agents directed at renal cell carcinoma. Mertins, S.D., Myers, T.G., Hollingshead, M., Dykes, D., Bodde, E., Tsai, P., Jefferis, C.A., Gupta, R., Linehan, W.M., Alley, M., Bates, S.E. Clin. Cancer Res. (2001) [Pubmed]
  20. Fresnel prisms improve visual perception in stroke patients with homonymous hemianopia or unilateral visual neglect. Rossi, P.W., Kheyfets, S., Reding, M.J. Neurology (1990) [Pubmed]
  21. Zygotic lethals with specific maternal effect phenotypes in Drosophila melanogaster. I. Loci on the X chromosome. Perrimon, N., Engstrom, L., Mahowald, A.P. Genetics (1989) [Pubmed]
  22. Using the national cancer institute anticancer drug screen to assess the effect of MRP expression on drug sensitivity profiles. Alvarez, M., Robey, R., Sandor, V., Nishiyama, K., Matsumoto, Y., Paull, K., Bates, S., Fojo, T. Mol. Pharmacol. (1998) [Pubmed]
  23. Leishmania chagasi T-Cell Antigens Identified through a Double Library Screen. Martins, D.R., Jeronimo, S.M., Donelson, J.E., Wilson, M.E. Infect. Immun. (2006) [Pubmed]
  24. Optimized genomic sequencing as a tool for the study of cytosine methylation in the regulatory region of the chicken vitellogenin II gene. Saluz, H., Jost, J.P. Gene (1986) [Pubmed]
  25. Insights from gene arrays on the development and growth regulation of uterine leiomyomata. Tsibris, J.C., Segars, J., Coppola, D., Mane, S., Wilbanks, G.D., O'Brien, W.F., Spellacy, W.N. Fertil. Steril. (2002) [Pubmed]
  26. The PEX Gene Screen: molecular diagnosis of peroxisome biogenesis disorders in the Zellweger syndrome spectrum. Steinberg, S., Chen, L., Wei, L., Moser, A., Moser, H., Cutting, G., Braverman, N. Mol. Genet. Metab. (2004) [Pubmed]
  27. Protein-linked DNA strand breaks induced by NSC 314622, a novel noncamptothecin topoisomerase I poison. Kohlhagen, G., Paull, K.D., Cushman, M., Nagafuji, P., Pommier, Y. Mol. Pharmacol. (1998) [Pubmed]
  28. Thymidine kinase, thymidylate synthase, and dihydropyrimidine dehydrogenase profiles of cell lines of the National Cancer Institute's Anticancer Drug Screen. Grem, J.L., Danenberg, K.D., Behan, K., Parr, A., Young, L., Danenberg, P.V., Nguyen, D., Drake, J., Monks, A., Allegra, C.J. Clin. Cancer Res. (2001) [Pubmed]
  29. Ethanol-induced microaggregate formation in pig and rabbit blood. An in vitro study. Elmér, O., Göransson, G., Saku, M., Bengmark, S. Thromb. Haemost. (1977) [Pubmed]
  30. Oxaliplatin, tetraplatin, cisplatin, and carboplatin: spectrum of activity in drug-resistant cell lines and in the cell lines of the National Cancer Institute's Anticancer Drug Screen panel. Rixe, O., Ortuzar, W., Alvarez, M., Parker, R., Reed, E., Paull, K., Fojo, T. Biochem. Pharmacol. (1996) [Pubmed]
  31. Selective toxicity of the tricyclic thiophene NSC 652287 in renal carcinoma cell lines: differential accumulation and metabolism. Rivera, M.I., Stinson, S.F., Vistica, D.T., Jorden, J.L., Kenney, S., Sausville, E.A. Biochem. Pharmacol. (1999) [Pubmed]
  32. Targeting tumor cells via EGF receptors: selective toxicity of an HBEGF-toxin fusion protein. Chandler, L.A., Sosnowski, B.A., McDonald, J.R., Price, J.E., Aukerman, S.L., Baird, A., Pierce, G.F., Houston, L.L. Int. J. Cancer (1998) [Pubmed]
  33. Evidence of a reduced DNA topoisomerase II mRNA expression after ionizing radiation. Goldwasser, F., Bae, I., Pommier, Y., Fornace, A.J. Anticancer Res. (1999) [Pubmed]
  34. Anthrax lethal factor causes proteolytic inactivation of mitogen-activated protein kinase kinase. Duesbery, N.S., Vande Woude, G.F. J. Appl. Microbiol. (1999) [Pubmed]
  35. Mutation Screen of the Cone-Specific Gene, CLUL1, in 376 Patients with Age-Related Macular Degeneration. Sturgill, G.M., Pauer, G.J., Bala, E., Simpson, E., Yaniglos, S.S., Crabb, J.W., Hollyfield, J.G., Lewis, H., Peachey, N.S., Hagstrom, S.A. Ophthalmic Genet. (2006) [Pubmed]
  36. Fatigue, menopausal symptoms, and cognitive function in women after adjuvant chemotherapy for breast cancer: 1- and 2-year follow-up of a prospective controlled study. Fan, H.G., Houédé-Tchen, N., Yi, Q.L., Chemerynsky, I., Downie, F.P., Sabate, K., Tannock, I.F. J. Clin. Oncol. (2005) [Pubmed]
  37. Case-finding for depression in primary care: a randomized trial. Williams, J.W., Mulrow, C.D., Kroenke, K., Dhanda, R., Badgett, R.G., Omori, D., Lee, S. Am. J. Med. (1999) [Pubmed]
  38. Screening for hospitalization and nutritional risks among community-dwelling older persons. Jensen, G.L., Friedmann, J.M., Coleman, C.D., Smiciklas-Wright, H. Am. J. Clin. Nutr. (2001) [Pubmed]
  39. Nutritional risk assessment and obesity in rural older adults: a sex difference. Ledikwe, J.H., Smiciklas-Wright, H., Mitchell, D.C., Jensen, G.L., Friedmann, J.M., Still, C.D. Am. J. Clin. Nutr. (2003) [Pubmed]
  40. The Columbia Suicide Screen: validity and reliability of a screen for youth suicide and depression. Shaffer, D., Scott, M., Wilcox, H., Maslow, C., Hicks, R., Lucas, C.P., Garfinkel, R., Greenwald, S. Journal of the American Academy of Child and Adolescent Psychiatry. (2004) [Pubmed]
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