The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Mtm1  -  X-linked myotubular myopathy gene 1

Mus musculus

Synonyms: AF073996, Mtm, Myotubularin, Phosphatidylinositol-3,5-bisphosphate 3-phosphatase, Phosphatidylinositol-3-phosphate phosphatase, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Mtm1


Biological context of Mtm1


Anatomical context of Mtm1


Associations of Mtm1 with chemical compounds

  • To test this hypothesis, macrophage cellular levels of PtdIns-3-P were altered by retroviral introduction of the type III Phosphoinositide 3-Kinase (VPS34) and the PtdIns-3-P phosphatase myotubularin 1 (MTM1) [6].

Analytical, diagnostic and therapeutic context of Mtm1

  • These mutant mice represent animal models for the human disease and will be a valuable tool for understanding the physiological role of myotubularin [1].


  1. The lipid phosphatase myotubularin is essential for skeletal muscle maintenance but not for myogenesis in mice. Buj-Bello, A., Laugel, V., Messaddeq, N., Zahreddine, H., Laporte, J., Pellissier, J.F., Mandel, J.L. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. Expression of myotubularin by an adenoviral vector demonstrates its function as a phosphatidylinositol 3-phosphate [PtdIns(3)P] phosphatase in muscle cell lines: involvement of PtdIns(3)P in insulin-stimulated glucose transport. Chaussade, C., Pirola, L., Bonnafous, S., Blondeau, F., Brenz-Verca, S., Tronchère, H., Portis, F., Rusconi, S., Payrastre, B., Laporte, J., Van Obberghen, E. Mol. Endocrinol. (2003) [Pubmed]
  3. Early and severe presentation of X-linked myotubular myopathy in a girl with skewed X-inactivation. Jungbluth, H., Sewry, C.A., Buj-Bello, A., Kristiansen, M., Ørstavik, K.H., Kelsey, A., Manzur, A.Y., Mercuri, E., Wallgren-Pettersson, C., Muntoni, F. Neuromuscul. Disord. (2003) [Pubmed]
  4. Identification of genes induced by rapid intraoperative tissue expansion in mouse skin. Zhu, Y., Luo, J., Barker, J., Hochberg, J., Cilento, E., Reilly, F. Arch. Dermatol. Res. (2002) [Pubmed]
  5. Gene expression analyses in X-linked myotubular myopathy. Noguchi, S., Fujita, M., Murayama, K., Kurokawa, R., Nishino, I. Neurology (2005) [Pubmed]
  6. Modulation of cellular phosphatidylinositol 3-phosphate levels in primary macrophages affects heat-killed but not viable Mycobacterium avium's transport through the phagosome maturation process. Kelley, V.A., Schorey, J.S. Cell. Microbiol. (2004) [Pubmed]
WikiGenes - Universities