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Gene Review

Mug1  -  murinoglobulin 1

Mus musculus

Synonyms: MuG1, Mug-1, Murinoglobulin-1
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Disease relevance of Mug1


High impact information on Mug1


Biological context of Mug1


Other interactions of Mug1


Analytical, diagnostic and therapeutic context of Mug1

  • Southern blotting of genomic DNA from five different mouse strains confirmed this analysis and even suggested the possible existence of a fifth murinoglobulin gene [8].
  • The interactions of mouse murinoglobulin and alpha-macroglobulin with several proteinases were investigated by filtration and by assays of amidolytic activity towards synthetic substrates in the presence of proteinaceous enzyme inhibitors as well as assays of the inhibition of proteolytic activity [3].
  • The treatment of murinoglobulin at the ratio of 40 considerably suppressed the swelling up to 60 min after subcutaneous injection of L. muta muta and E. c. sochureki venoms, and up to 30 min after T. flavoviridis venom injection [11].


  1. alpha2-macroglobulin- and murinoglobulin-1- deficient mice. A mouse model for acute pancreatitis. Umans, L., Serneels, L., Overbergh, L., Stas, L., Van Leuven, F. Am. J. Pathol. (1999) [Pubmed]
  2. Increased Trypanosoma cruzi invasion and heart fibrosis associated with high transforming growth factor beta levels in mice deficient in alpha(2)-macroglobulin. Waghabi, M.C., Coutinho, C.M., Soeiro, M.N., Pereira, M.C., Feige, J.J., Keramidas, M., Cosson, A., Minoprio, P., Van Leuven, F., Araújo-Jorge, T.C. Infect. Immun. (2002) [Pubmed]
  3. Proteinase inhibitory spectrum of mouse murinoglobulin and alpha-macroglobulin. Abe, K., Yamamoto, K., Sinohara, H. J. Biochem. (1989) [Pubmed]
  4. Serine proteinase inhibitor 3 and murinoglobulin I are potent inhibitors of neuropsin in adult mouse brain. Kato, K., Kishi, T., Kamachi, T., Akisada, M., Oka, T., Midorikawa, R., Takio, K., Dohmae, N., Bird, P.I., Sun, J., Scott, F., Miyake, Y., Yamamoto, K., Machida, A., Tanaka, T., Matsumoto, K., Shibata, M., Shiosaka, S. J. Biol. Chem. (2001) [Pubmed]
  5. Targeted inactivation of the mouse alpha 2-macroglobulin gene. Umans, L., Serneels, L., Overbergh, L., Lorent, K., Van Leuven, F., Van den Berghe, H. J. Biol. Chem. (1995) [Pubmed]
  6. Murinoglobulin, a novel protease inhibitor from murine plasma. Isolation, characterization, and comparison with murine alpha-macroglobulin and human alpha-2-macroglobulin. Saito, A., Sinohara, H. J. Biol. Chem. (1985) [Pubmed]
  7. Cloning and sequencing of cDNAs encoding plasma alpha-macroglobulin and murinoglobulin from guinea pig: implications for molecular evolution of alpha-macroglobulin family. Iwasaki, H., Suzuki, Y., Sinohara, H. J. Biochem. (1996) [Pubmed]
  8. Identification of four genes coding for isoforms of murinoglobulin, the monomeric mouse alpha 2-macroglobulin: characterization of the exons coding for the bait region. Overbergh, L., Hilliker, C., Lorent, K., Van Leuven, F., Van den Berghe, H. Genomics (1994) [Pubmed]
  9. Rat plasma murinoglobulin: isolation, characterization, and comparison with rat alpha-1- and alpha-2-macroglobulins. Saito, A., Sinohara, H. J. Biochem. (1985) [Pubmed]
  10. Guinea pig plasma murinoglobulin. Purification and some properties. Suzuki, Y., Sinohara, H. Biol. Chem. Hoppe-Seyler (1986) [Pubmed]
  11. Inhibition of hemorrhagic and edematogenic activities of snake venoms by a broad-spectrum protease inhibitor, murinoglobulin; the effect on venoms from five different genera in Viperidae family. Ribeiro Filho, W., Sugiki, M., Yoshida, E., Maruyama, M. Toxicon (2003) [Pubmed]
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