Disease relevance of p

• Pink-eyed dilution gene (P) mutations are the most common cause of tyrosinase-positive oculocutaneous albinism worldwide [1].
• We focused on the trait of albinism and discovered that it is linked to Oca2, a known pigmentation gene, in two cave populations [2].
• The Sendai virus (SeV) V protein is characterized by the unique cysteine-rich domain in its carboxy-terminal half which is fused to the amino-terminal half of the P protein, but its function has remained enigmatic [3].
• Phosphorylation of P proteins in several negative strand RNA viruses by specific cellular kinases was found to be required for P protein function [4].
• In the present study, using bacterially expressed unphosphorylated P protein of Sendai virus, a mouse parainfluenza virus, we have shown that the major cellular kinase that phosphorylates P protein in vitro is biochemically and immunologically indistinguishable from protein kinase C (PKC) zeta isoform [4].

High impact information on p

• Pink-eyed dilution protein controls the processing of tyrosinase [5].
• Pink-eyed dilution protein modulates arsenic sensitivity and intracellular glutathione metabolism [6].
• Extensive attenuation of rabies virus by simultaneously modifying the dynein light chain binding site in the P protein and replacing Arg333 in the G protein [7].
• The P gene-deficient (def-P) virus replicated its genome and produced progeny viruses in the cell lines that constitutively expressed the P protein, although it grew at a slightly retarded rate compared to the parental strain [8].
• Inverse correlation between pink-eyed dilution protein expression and induction of melanogenesis by bafilomycin A1 [1].

Anatomical context of p

• Pink-eyed dilution (p/p) is a recessive mutation in mice which results in reduced pigmentation of the retinal pigment epithelium, as well as alterations in visual pathways and function [9].
• Antibodies from 11 hybridomas immunoprecipitated N and F1 proteins, one hybridoma immunoprecipitated the N and P protein, and 5 hybridomas immunoprecipitated the N protein [10].

Associations of p with chemical compounds

• On the contrary, the amount of GST-P mRNA of C6R cells was 1.3-fold larger than C6 cells and that of GST-P protein of C6R cells was 1.3-fold larger than C6 cells [11].

Other interactions of p

• The pinkeyed-dilution protein and the eumelanin/pheomelanin switch: in support of a unifying hypothesis [12].

References