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Gene Review

Prkce  -  protein kinase C, epsilon

Mus musculus

Synonyms: 5830406C15Rik, PKC[e], PKCepsilon, Pkce, Pkcea, ...
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Disease relevance of Prkce


High impact information on Prkce

  • The implication of protein kinase C (PKC) isoforms cPKC-alpha, nPKC-epsilon, aPKC-lambda and aPKC-zeta in the transcriptional activation of a c-fos promoter-driven CAT-reporter construct by transforming Ha-Ras has been investigated [3].
  • We conclude that under physiological conditions, conventional cPKC-alpha and novel nPKC-epsilon, but not atypical aPKC-lambda are responsible for MARCKS phosphorylation in intact NIH 3T3 fibroblasts [4].
  • Northern blot analysis showed that the mRNA for nPKC eta is highly expressed in the lung and skin but, in contrast to other members of the PKC family, only slightly expressed in the brain. nPKC eta expressed in COS cells shows phorbol ester binding activity with a similar affinity to nPKC epsilon [5].
  • As compared to vector control cell lines expressing only the hygromycin resistance gene, the nPKC epsilon overproducing cell lines exhibited a 7-13-fold increase in Ca(2+)-independent enzyme activity [6].
  • We have overproduced the Ca(2+)-independent protein kinase C isoform, nPKC epsilon, in Rat 6 embryo fibroblasts, and examined the effects of this novel isoform on cell growth and transformation [6].

Anatomical context of Prkce


Other interactions of Prkce

  • Modest increases in novel PKC-epsilon (nPKC-epsilon) expression and subcellular membrane partitioning were recorded during TMCH, but no changes were seen for PKC-delta or -eta [7].
  • In a mouse neuroblast cell line, Neuro 2a, down modulation of mRNAs for both PKC alpha and nPKC epsilon was observed in association with in vitro differentiation [1].


  1. Cell type-specific expression of the genes for the protein kinase C family: down regulation of mRNAs for PKC alpha and nPKC epsilon upon in vitro differentiation of a mouse neuroblastoma cell line neuro 2a. Wada, H., Ohno, S., Kubo, K., Taya, C., Tsuji, S., Yonehara, S., Suzuki, K. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  2. Mechanisms of gender-specific TCDD-induced toxicity in guinea pig adipose tissue. Enan, E., El-Sabeawy, F., Overstreet, J., Matsumura, F., Lasley, B. Reprod. Toxicol. (1998) [Pubmed]
  3. Transcriptional activation of c-fos by oncogenic Ha-Ras in mouse mammary epithelial cells requires the combined activities of PKC-lambda, epsilon and zeta. Kampfer, S., Hellbert, K., Villunger, A., Doppler, W., Baier, G., Grunicke, H.H., Uberall, F. EMBO J. (1998) [Pubmed]
  4. Conventional PKC-alpha, novel PKC-epsilon and PKC-theta, but not atypical PKC-lambda are MARCKS kinases in intact NIH 3T3 fibroblasts. Uberall, F., Giselbrecht, S., Hellbert, K., Fresser, F., Bauer, B., Gschwendt, M., Grunicke, H.H., Baier, G. J. Biol. Chem. (1997) [Pubmed]
  5. A phorbol ester receptor/protein kinase, nPKC eta, a new member of the protein kinase C family predominantly expressed in lung and skin. Osada, S., Mizuno, K., Saido, T.C., Akita, Y., Suzuki, K., Kuroki, T., Ohno, S. J. Biol. Chem. (1990) [Pubmed]
  6. The epsilon isoform of protein kinase C is an oncogene when overexpressed in rat fibroblasts. Cacace, A.M., Guadagno, S.N., Krauss, R.S., Fabbro, D., Weinstein, I.B. Oncogene (1993) [Pubmed]
  7. Murine colonic mucosa hyperproliferation. II. PKC-beta activation and cPKC-mediated cellular CFTR overexpression. Umar, S., Sellin, J.H., Morris, A.P. Am. J. Physiol. Gastrointest. Liver Physiol. (2000) [Pubmed]
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