Gene Review:
Marcks - myristoylated alanine rich protein kinase...
Mus musculus
Synonyms:
MARCKS, Macs, Myristoylated alanine-rich C-kinase substrate, PKCSL
- Promoter sequence, expression, and fine chromosomal mapping of the human gene (MLP) encoding the MARCKS-like protein: identification of neighboring and linked polymorphic loci for MLP and MACS and use in the evaluation of human neural tube defects. Stumpo, D.J., Eddy, R.L., Haley, L.L., Sait, S., Shows, T.B., Lai, W.S., Young, W.S., Speer, M.C., Dehejia, A., Polymeropoulos, M., Blackshear, P.J. Genomics (1998)
- Myristoylation-dependent N-terminal cleavage of the myristoylated alanine-rich C kinase substrate (MARCKS) by cellular extracts. Braun, T., McIlhinney, R.A., Vergères, G. Biochimie (2000)
- Effect of reduced myristoylated alanine-rich C kinase substrate expression on hippocampal mossy fiber development and spatial learning in mutant mice: transgenic rescue and interactions with gene background. McNamara, R.K., Stumpo, D.J., Morel, L.M., Lewis, M.H., Wakeland, E.K., Blackshear, P.J., Lenox, R.H. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Phosphorylation of the MARCKS family of protein kinase C substrates in human B chronic lymphocytic leukemia cells. Carballo, E., Colomer, D., Vives Corrons, J.L., Blackshear, P.J., Gil, J. Leukemia (1995)
- Chromosomal mapping of the human (MACS) and mouse (Macs) genes encoding the MARCKS protein. Blackshear, P.J., Tuttle, J.S., Oakey, R.J., Seldin, M.F., Chery, M., Philippe, C., Stumpo, D.J. Genomics (1992)
- Myristoylated alanine rich C kinase substrate (MARCKS) heterozygous mutant mice exhibit deficits in hippocampal mossy fiber-CA3 long-term potentiation. Hussain, R.J., Stumpo, D.J., Blackshear, P.J., Lenox, R.H., Abel, T., McNamara, R.K. Hippocampus. (2006)
- MacMARCKS, a novel member of the MARCKS family of protein kinase C substrates. Li, J., Aderem, A. Cell (1992)
- A MARCKS-related peptide blocks mucus hypersecretion in a mouse model of asthma. Singer, M., Martin, L.D., Vargaftig, B.B., Park, J., Gruber, A.D., Li, Y., Adler, K.B. Nat. Med. (2004)
- Activation of protein kinase C results in the displacement of its myristoylated, alanine-rich substrate from punctate structures in macrophage filopodia. Rosen, A., Keenan, K.F., Thelen, M., Nairn, A.C., Aderem, A. J. Exp. Med. (1990)
- Differential expression of MARCKS and other calmodulin-binding protein kinase C substrates in cultured neuroblastoma and glioma cells. Rosé, S.D., Cook, H.W., Palmer, F.B., Ridgway, N.D., Byers, D.M. J. Neurochem. (1994)
- Ca2+ x calmodulin prevents myristoylated alanine-rich kinase C substrate protein phosphorylation by protein kinase Cs in C6 rat glioma cells. Chakravarthy, B.R., Isaacs, R.J., Morley, P., Whitfield, J.F. J. Biol. Chem. (1995)
- v-Jun targets showing an expression pattern that correlates with the transformed cellular phenotype. Iacovoni, J.S., Cohen, S.B., Berg, T., Vogt, P.K. Oncogene (2004)
- Neuroanatomical development in the absence of PKC phosphorylation of the myristoylated alanine-rich C-kinase substrate (MARCKS) protein. Scarlett, C.O., Blackshear, P.J. Brain Res. Dev. Brain Res. (2003)
- The myristoyl moiety of myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein is embedded in the membrane. Vergères, G., Manenti, S., Weber, T., Stürzinger, C. J. Biol. Chem. (1995)
- Poly(ADP-ribose) modulates the properties of MARCKS proteins. Schmitz, A.A., Pleschke, J.M., Kleczkowska, H.E., Althaus, F.R., Vergères, G. Biochemistry (1998)
- Cell type-specific upregulation of myristoylated alanine-rich C kinase substrate and protein kinase C-alpha, -beta I, -beta II, and -delta in microglia following kainic acid-induced seizures. Eun, S.Y., Kim, E.H., Kang, K.S., Kim, H.J., Jo, S.A., Kim, S.J., Jo, S.H., Kim, S.J., Blackshear, P.J., Kim, J. Exp. Mol. Med. (2006)
- Binding of MARCKS (myristoylated alanine-rich C kinase substrate)-related protein (MRP) to vesicular phospholipid membranes. Vergères, G., Ramsden, J.J. Biochem. J. (1998)
- Inhibition of mucin secretion with MARCKS-related peptide improves airway obstruction in a mouse model of asthma. Agrawal, A., Rengarajan, S., Adler, K.B., Ram, A., Ghosh, B., Fahim, M., Dickey, B.F. J. Appl. Physiol. (2007)
- Macrophage-enriched myristoylated alanine-rich C kinase substrate and its phosphorylation is required for the phorbol ester-stimulated diffusion of beta 2 integrin molecules. Zhou, X., Li, J. J. Biol. Chem. (2000)
- Conventional PKC-alpha, novel PKC-epsilon and PKC-theta, but not atypical PKC-lambda are MARCKS kinases in intact NIH 3T3 fibroblasts. Uberall, F., Giselbrecht, S., Hellbert, K., Fresser, F., Bauer, B., Gschwendt, M., Grunicke, H.H., Baier, G. J. Biol. Chem. (1997)
- MARCKS-related protein binds to actin without significantly affecting actin polymerization or network structure. Myristoylated alanine-rich C kinase substrate. Wohnsland, F., Steinmetz, M.O., Aebi, U., Vergères, G. J. Struct. Biol. (2000)
- p42 MAPK phosphorylates 80 kDa MARCKS at Ser-113. Schönwasser, D.C., Palmer, R.H., Herget, T., Parker, P.J. FEBS Lett. (1996)
- Biologically active milli-calpain associated with caveolae is involved in a spatially compartmentalised signalling involving protein kinase C alpha and myristoylated alanine-rich C-kinase substrate (MARCKS). Goudenege, S., Poussard, S., Dulong, S., Cottin, P. Int. J. Biochem. Cell Biol. (2005)
- Bombesin, endothelin and platelet-derived growth factor induce rapid translocation of the myristoylated alanine-rich C-kinase substrate in Swiss 3T3 cells. Herget, T., Rozengurt, E. Eur. J. Biochem. (1994)
- In vivo effects of doxorubicin on kinase C in cultured cells. Otsuka, M., Shigeoka, H., Yang, H.C. Cancer Chemother. Pharmacol. (1992)
- Phosphorylated MARCKS: a novel centrosome component that also defines a peripheral subdomain of the cortical actin cap in mouse eggs. Michaut, M.A., Williams, C.J., Schultz, R.M. Dev. Biol. (2005)
- Molecular cloning, expression and chromosomal localisation of the mouse Rev3l gene, encoding the catalytic subunit of polymerase zeta. Van Sloun, P.P., Romeijn, R.J., Eeken, J.C. Mutat. Res. (1999)
- Induction of protein kinase C substrates, Myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein (MRP), by amyloid beta-protein in mouse BV-2 microglial cells. Murphy, A., Sunohara, J.R., Sundaram, M., Ridgway, N.D., McMaster, C.R., Cook, H.W., Byers, D.M. Neurosci. Lett. (2003)
- Cloning and molecular characterization of the murine macrophage "68-kDa" protein kinase C substrate and its regulation by bacterial lipopolysaccharide. Seykora, J.T., Ravetch, J.V., Aderem, A. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Differential expression and regulation of myristoylated alanine-rich C kinase substrate (MARCKS) in the hippocampus of C57/BL6J and DBA/2J mice. McNamara, R.K., Vasquez, P.A., Mathe, A.A., Lenox, R.H. J. Neurochem. (2003)