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Gene Review

pde-6  -  Protein PDE-6

Caenorhabditis elegans

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High impact information on phosphodiesterase


Anatomical context of phosphodiesterase

  • Wnt regulation of intracellular Ca2+ and cGMP levels requires the G protein transducin and a cGMP-specific phosphodiesterase, which are major elements in signaling of the visual pathway [6].

Associations of phosphodiesterase with chemical compounds


  1. The Dunce cAMP phosphodiesterase PDE-4 negatively regulates G alpha(s)-dependent and G alpha(s)-independent cAMP pools in the Caenorhabditis elegans synaptic signaling network. Charlie, N.K., Thomure, A.M., Schade, M.A., Miller, K.G. Genetics (2006) [Pubmed]
  2. Cloning and gene structure of the rod cGMP phosphodiesterase delta subunit gene (PDED) in man and mouse. Lorenz, B., Migliaccio, C., Lichtner, P., Meyer, C., Strom, T.M., D'Urso, M., Becker, J., Ciccodicola, A., Meitinger, T. Eur. J. Hum. Genet. (1998) [Pubmed]
  3. Expression and characterization of human PDEdelta and its Caenorhabditis elegans ortholog CEdelta. Li, N., Baehr, W. FEBS Lett. (1998) [Pubmed]
  4. Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13. Couch, F.J., Rommens, J.M., Neuhausen, S.L., Bélanger, C., Dumont, M., Abel, K., Bell, R., Berry, S., Bogden, R., Cannon-Albright, L., Farid, L., Frye, C., Hattier, T., Janecki, T., Jiang, P., Kehrer, R., Leblanc, J.F., McArthur-Morrison, J., Meney, D., Miki, Y., Peng, Y., Samson, C., Schroeder, M., Snyder, S.C., Simard, J. Genomics (1996) [Pubmed]
  5. Assay and functional properties of PrBP(PDEdelta), a prenyl-binding protein interacting with multiple partners. Zhang, H., Hosier, S., Terew, J.M., Zhang, K., Cote, R.H., Baehr, W. Meth. Enzymol. (2005) [Pubmed]
  6. Wnt signaling, Ca2+, and cyclic GMP: visualizing Frizzled functions. Wang, H.Y., Malbon, C.C. Science (2003) [Pubmed]
  7. Studies on the role of histamine and 5-hydroxytryptamine in immunity against the nematode Trichostrongylus colubriformis. IV. Inhibition of the expulsion of worms transplanted into the duodenum of immune guinea pigs. Rothwell, T.L., Love, R.J., Evans, D.P. Int. Arch. Allergy Appl. Immunol. (1978) [Pubmed]
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