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Gene Review

Psmb6  -  proteasome (prosome, macropain) subunit,...

Mus musculus

Synonyms: Lmp19, Low molecular mass protein 19, Macropain delta chain, Mpnd, Multicatalytic endopeptidase complex delta chain, ...
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High impact information on Psmb6

  • While mYa was shown to be identical to the known alpha-class glutathione S-transferase complementary DNA clone pGT41 (W. R. Pearson et al., J. Biol. Chem., 263: 13324-13332, 1988), the other clone, mYc, was demonstrated to be a novel complementary DNA clone encoding a glutathione S-transferase homologous to rat Yc (subunit 2) [1].
  • Derepression occurs in response to inducers, to oligodeoxynucleotides antisense to Gsalpha, and to overexpression of heterotrimeric G-protein alpha subunit 2, inhibitory with respect to adenylyl cyclase (Gialpha2) [2].
  • To identify mossy cells in the rat, we utilized an antibody to the glutamate receptor subunit 2/3 (GluR2/3) [3].
  • However, here we show that unlike most other MHC class I molecules, TL is expressed efficiently in the absence of functional transporter associated with antigen processing subunit 2 (TAP2) [4].
  • Additionally, Western blot and immunocytochemistry confirmed presence of the PPP1C regulatory inhibitor subunit 2 (PPP1R2) in oocytes at condensed chromatin during meiosis and indicated a change in PPP1R2 phosphorylation [5].

Biological context of Psmb6

  • BXD recombinant inbred (RI) mice were used to map the potential chromosomal location of Lmp19, and revealed that the DELTA subunit has related sequences present on two different mouse chromosomes, chromosomes 1 and 11 [6].
  • Sequence analysis of the mouse gene encoding DELTA, designated Lmp19, indicates that it consists of six exons and five introns, similar to the Lmp2 gene [6].

Regulatory relationships of Psmb6

  • 2. The G-protein-activated inwardly rectifying potassium channel subunit 2 (GIRK2) is expressed in cerebellum and can shunt dendritic conductance and attenuate postsynaptic potentials [7].

Other interactions of Psmb6


  1. Complementary DNA cloning, messenger RNA expression, and induction of alpha-class glutathione S-transferases in mouse tissues. Buetler, T.M., Eaton, D.L. Cancer Res. (1992) [Pubmed]
  2. Repression of adipogenesis by adenylyl cyclase stimulatory G-protein alpha subunit is expressed within region 146-220. Wang, H., Johnson, G.L., Liu, X., Malbon, C.C. J. Biol. Chem. (1996) [Pubmed]
  3. Type II glucocorticoid receptor immunoreactivity in the mossy cells of the rat and the mouse hippocampus. Patel, A., Bulloch, K. Hippocampus. (2003) [Pubmed]
  4. Surface expression of beta 2-microglobulin-associated thymus-leukemia antigen is independent of TAP2. Rodgers, J.R., Mehta, V., Cook, R.G. Eur. J. Immunol. (1995) [Pubmed]
  5. Proper chromatin condensation and maintenance of histone h3 phosphorylation during mouse oocyte meiosis requires protein phosphatase activity. Swain, J.E., Ding, J., Brautigan, D.L., Villa-Moruzzi, E., Smith, G.D. Biol. Reprod. (2007) [Pubmed]
  6. Characterization and mapping of the gene encoding mouse proteasome subunit DELTA (Lmp19). Woodward, E.C., Monaco, J.J. Immunogenetics (1995) [Pubmed]
  7. Elevated Expression of the G-Protein-Activated Inwardly Rectifying Potassium Channel 2 (GIRK2) in Cerebellar Unipolar Brush Cells of a Down Syndrome Mouse Model. Harashima, C., Jacobowitz, D.M., Stoffel, M., Chakrabarti, L., Haydar, T.F., Siarey, R.J., Galdzicki, Z. Cell. Mol. Neurobiol. (2006) [Pubmed]
  8. Functional characterization of the promoter for the mouse SPTLC2 gene, which encodes subunit 2 of serine palmitoyltransferase. Linn, S.C., Andras, L.M., Kim, H.S., Wei, J., Nagiec, M.M., Dickson, R.C., Merrill, A.H. FEBS Lett. (2006) [Pubmed]
  9. Evaluation of HCN2 abnormalities as a cause of juvenile audiogenic seizures in Black Swiss mice. Shin, M., Simkin, D., Suyeoka, G.M., Chetkovich, D.M. Brain Res. (2006) [Pubmed]
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