Gene Review:
Kcnj6 - potassium inwardly-rectifying channel,...
Mus musculus
Synonyms:
BIR1, G protein-activated inward rectifier potassium channel 2, GIRK-2, GIRK2, Girk2, ...
- Metallothionein-mediated neuroprotection in genetically engineered mouse models of Parkinson's disease. Ebadi, M., Brown-Borg, H., El Refaey, H., Singh, B.B., Garrett, S., Shavali, S., Sharma, S.K. Brain Res. Mol. Brain Res. (2005)
- The mouse neurological mutant weaver maps within the region of chromosome 16 that is homologous to human chromosome 21. Reeves, R.H., Crowley, M.R., Lorenzon, N., Pavan, W.J., Smeyne, R.J., Goldowitz, D. Genomics (1989)
- G-protein-gated potassium (GIRK) channels containing the GIRK2 subunit are control hubs for pharmacologically induced hypothermic responses. Costa, A.C., Stasko, M.R., Stoffel, M., Scott-McKean, J.J. J. Neurosci. (2005)
- Spinal G-protein-gated K+ channels formed by GIRK1 and GIRK2 subunits modulate thermal nociception and contribute to morphine analgesia. Marker, C.L., Stoffel, M., Wickman, K. J. Neurosci. (2004)
- Hypothalamic-pituitary-gonadal axis in the mutant weaver mouse. Schwartz, N.B., Szabo, M., Verina, T., Wei, J., Dlouhy, S.R., Won, L., Heller, A., Hodes, M.E., Ghetti, B. Neuroendocrinology (1998)
- Hyperactivity and dopamine D1 receptor activation in mice lacking girk2 channels. Blednov, Y.A., Stoffel, M., Cooper, R., Wallace, D., Mane, N., Harris, R.A. Psychopharmacology (Berl.) (2002)
- Contribution of GIRK2-mediated postsynaptic signaling to opiate and alpha 2-adrenergic analgesia and analgesic sex differences. Mitrovic, I., Margeta-Mitrovic, M., Bader, S., Stoffel, M., Jan, L.Y., Basbaum, A.I. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Nonselective and G betagamma-insensitive weaver K+ channels. Navarro, B., Kennedy, M.E., Velimirovíc, B., Bhat, D., Peterson, A.S., Clapham, D.E. Science (1996)
- Neuronal differentiation rescued by implantation of Weaver granule cell precursors into wild-type cerebellar cortex. Gao, W.Q., Hatten, M.E. Science (1993)
- Adenosine receptors: autoradiographic evidence for their location on axon terminals of excitatory neurons. Goodman, R.R., Kuhar, M.J., Hester, L., Snyder, S.H. Science (1983)
- Ethanol opens G-protein-activated inwardly rectifying K+ channels. Kobayashi, T., Ikeda, K., Kojima, H., Niki, H., Yano, R., Yoshioka, T., Kumanishi, T. Nat. Neurosci. (1999)
- G protein-coupled inwardly rectifying K+ channels (GIRKs) mediate postsynaptic but not presynaptic transmitter actions in hippocampal neurons. Lüscher, C., Jan, L.Y., Stoffel, M., Malenka, R.C., Nicoll, R.A. Neuron (1997)
- Decreased cocaine self-administration in Kir3 potassium channel subunit knockout mice. Morgan, A.D., Carroll, M.E., Loth, A.K., Stoffel, M., Wickman, K. Neuropsychopharmacology (2003)
- Potassium channels as targets for ethanol: studies of G-protein-coupled inwardly rectifying potassium channel 2 (GIRK2) null mutant mice. Blednov, Y.A., Stoffel, M., Chang, S.R., Harris, R.A. J. Pharmacol. Exp. Ther. (2001)
- Hypothermic responses to 8-OH-DPAT in the Ts65Dn mouse model of Down syndrome. Stasko, M.R., Scott-McKean, J.J., Costa, A.C. Neuroreport (2006)
- Pancreatic islet cells express a family of inwardly rectifying K+ channel subunits which interact to form G-protein-activated channels. Ferrer, J., Nichols, C.G., Makhina, E.N., Salkoff, L., Bernstein, J., Gerhard, D., Wasson, J., Ramanadham, S., Permutt, A. J. Biol. Chem. (1995)
- An immunocytochemical study of a G-protein-gated inward rectifier K+ channel (GIRK2) in the weaver mouse mesencephalon. Adelbrecht, C., Murer, M.G., Lauritzen, I., Lesage, F., Ladzunski, M., Agid, Y., Raisman-Vozari, R. Neuroreport (1997)
- Developmental expression of the GIRK family of inward rectifying potassium channels: implications for abnormalities in the weaver mutant mouse. Chen, S.C., Ehrhard, P., Goldowitz, D., Smeyne, R.J. Brain Res. (1997)
- Heteromultimerization of G-protein-gated inwardly rectifying K+ channel proteins GIRK1 and GIRK2 and their altered expression in weaver brain. Liao, Y.J., Jan, Y.N., Jan, L.Y. J. Neurosci. (1996)
- Ts65Dn, a Mouse Model of Down Syndrome, Exhibits Increased GABAB-Induced Potassium Current. Best, T.K., Siarey, R.J., Galdzicki, Z. J. Neurophysiol. (2007)
- Cellular distribution of the RNA transcripts of a newly discovered gene in the brain of normal, weaver, Purkinje cell degeneration and reeler mutant mice as evidenced by in situ hybridization histochemistry. Kambouris, M., Sangameswaran, L., Dlouhy, S.R., Hodes, M.E., Ghetti, B., Triarhou, L.C. Brain Res. Mol. Brain Res. (1993)
- Ventral mesencephalic grafts in the neostriatum of the weaver mutant mouse: structural molecule and receptor studies. Triarhou, L.C., Solà, C., Mengod, G., García-Ladona, F.J., Landwehrmeyer, B., Ghetti, B., Palacios, J.M. Cell transplantation. (1995)
- Effect of the weaver mutation on the expression of dopamine membrane transporter, tyrosine hydroxylase and vesicular monoamine transporter in dopaminergic neurons of the substantia nigra and the ventral tegmental area. Adelbrecht, C., Agid, Y., Raisman-Vozari, R. Brain Res. Mol. Brain Res. (1996)
- Defective gamma-aminobutyric acid type B receptor-activated inwardly rectifying K+ currents in cerebellar granule cells isolated from weaver and Girk2 null mutant mice. Slesinger, P.A., Stoffel, M., Jan, Y.N., Jan, L.Y. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Molecular and cellular diversity of neuronal G-protein-gated potassium channels. Koyrakh, L., Luján, R., Colón, J., Karschin, C., Kurachi, Y., Karschin, A., Wickman, K. J. Neurosci. (2005)
- Weaver mutant mouse cerebellar granule cells respond normally to chronic depolarization. Bjerregaard, A., Mogensen, H.S., Hack, N., Balázs, R., Jørgensen, O.S. Int. J. Dev. Neurosci. (1997)
- Distribution of glutamate receptors of the NMDA subtype in brains of heterozygous and homozygous weaver mutant mice. Reader, T.A., Sénécal, J. Neurochem. Res. (2001)
- Molecular properties of neuronal G-protein-activated inwardly rectifying K+ channels. Lesage, F., Guillemare, E., Fink, M., Duprat, F., Heurteaux, C., Fosset, M., Romey, G., Barhanin, J., Lazdunski, M. J. Biol. Chem. (1995)
- Abnormal expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in hippocampus, frontal cortex, and substantia nigra of Ts65Dn mouse: a model of Down syndrome. Harashima, C., Jacobowitz, D.M., Witta, J., Borke, R.C., Best, T.K., Siarey, R.J., Galdzicki, Z. J. Comp. Neurol. (2006)
- The weaver mouse gain-of-function phenotype of dopaminergic midbrain neurons is determined by coactivation of wvGirk2 and K-ATP channels. Liss, B., Neu, A., Roeper, J. J. Neurosci. (1999)
- Parallin, a cerebellar granule cell protein the expression of which is developmentally regulated by Purkinje cells: evidence from mutant mice. Smith, A.M., Mullen, R.J. Brain Res. Dev. Brain Res. (1997)
- Hyperalgesia and blunted morphine analgesia in G protein-gated potassium channel subunit knockout mice. Marker, C.L., Cintora, S.C., Roman, M.I., Stoffel, M., Wickman, K. Neuroreport (2002)
- D3 dopamine autoreceptors do not activate G-protein-gated inwardly rectifying potassium channel currents in substantia nigra dopamine neurons. Davila, V., Yan, Z., Craciun, L.C., Logothetis, D., Sulzer, D. J. Neurosci. (2003)
- Partial restoration of striatal GABAA receptor balance by functional mesencephalic dopaminergic grafts in mice with hereditary parkinsonism. Stasi, K., Mitsacos, A., Giompres, P., Kouvelas, E.D., Triarhou, L.C. Exp. Neurol. (1999)