The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

PSMB6  -  proteasome (prosome, macropain) subunit,...

Homo sapiens

Synonyms: DELTA, LMPY, Macropain delta chain, Multicatalytic endopeptidase complex delta chain, Proteasome delta chain, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PSMB6

  • Based on the inability of this comprehensive analysis to uncover molecular defects in Delta vif virions, we speculate that such defects are likely to be subtle and/or rare [1].
  • In the present study, we established a protocol for producing large quantities of vif-deficient HIV-1 (HIV-1/Delta vif) from an acute infection of nonpermissive T cells and performed a thorough examination of the defect in these virions [1].
  • Convergence was held constant during an experimental session, while vertical disparity was incremented in steps of 0.05 Delta after a subjective report of fusion, until the subject reported diplopia [2].
  • The Ro ribonucleoprotein is composed of hY RNA and a 60.7-kD peptide that is antigenic for autoantibodies produced by many patients with systemic lupus erythematosus or Sjögren's syndrome and mothers of newborns with complete congenital heart block [3].
  • Recent evidence suggests that CR binds to 52 kDaRo (Ro52) by a protein/protein interaction and binds to hY RNA and rubella virus RNA [4].

High impact information on PSMB6

  • A subset of hY RNAs is associated with erythrocyte Ro ribonucleoproteins [5].
  • These results indicate that apoptotic degradation of Y RNAs is dependent on caspase activation, which suggests that the nucleolytic activity responsible for hY RNA degradation is activated downstream of the caspase cascade [6].
  • Additional mammalian Y scRNA genes have been refractory to cloning due to interference from numerous hY-homologous pseudogenes and studies of hY RNA genes have been sparse [7].
  • The human Y4 small cytoplasmic RNA gene is controlled by upstream elements and resides on chromosome 7 with all other hY scRNA genes [7].
  • In addition, we found no consistent defect in the ability of Delta vif virions to perform intravirion reverse transcription under a variety of assay conditions, suggesting that the reverse transcription complexes in these particles can behave normally under cell-free conditions [1].

Chemical compound and disease context of PSMB6

  • Impact of National Schistosomiasis Control Program in Kafr El-Sheikh governorate, Nile Delta, Egypt: an independent evaluation [8].

Biological context of PSMB6

  • RESULTS: The analysis of gene expression profiles indicated that after the treatment of arsenic trioxide (0.5 micromol/L) 3 genes were up-regulated, among which, PSMB6 gene was involved in proteasome degradation pathway, and 18 genes related to RNA processing, protein synthesis, and signal transduction were down-regulated [9].
  • CONCLUSION: PSMB6 and ITGB1 genes may be related to the differentiation and/or apoptosis of NB4 cells induced by As2O3 [9].
  • SCHs and chromosome 7-enriched YACs were used to demonstrate that all four hY RNA genes reside on human chromosome 7 [7].
  • In addition, Southern blots with probes for each of the four hY RNAs indicate that hY RNA-like sequences are abundant in the human genome [10].
  • Although the frequency of reactivity to the TS1-RNA was higher in anti-SSA/Ro positive sera, the presence of either native or recombinant SSA/Ro antigen showed no detectable competition, and no apparent sequence homology was found between the TS1-RNA and hY RNA [11].

Anatomical context of PSMB6

  • Analysis of the hY RNA content of various human cell lines showed that all four human Y RNAs were present in all cell lines examined [12].

Associations of PSMB6 with chemical compounds

  • METHODS: Allergen-dependent airway inflammation and hyperresponsiveness was induced in conditional alpha4(Delta/Delta), VCAM-1(-/-), and beta2(-/-) mice [13].
  • We investigated the distribution and diversity of tetracycline resistance genes encoding ribosomal protection proteins (RPPs) in river and channel sediments of the Mekong Delta in Vietnam [14].
  • Fourteen indole alkaloids, Delta (14)-isoeburnamine ( 1), amsosinine ( 2), tabersonine, vincadifformine, lochnericine, tetrahydroalstonine, beta-yohimbine, isoeburnamine, minovicinine, picrinine, strictamine, rhazimine, vincanidine, and decarbomethoxytetrahydrosecamine, were isolated from AMSONIA SINENSIS [15].
  • Eleven of them were identified as known alkaloids, namely, scandine ( 2), Delta (14)-eburnamine ( 4), vindolinine N(b)-oxide ( 5), 11-methoxytabersonine ( 6), vindolinine ( 7), EPI-vindolinine N(b)-oxide ( 8), hazuntine ( 9), compactinervine ( 10), 11-hydroxytabersonine ( 11), Delta (14)-vincine ( 12), and normacusine B ( 14) [16].
  • The sequence had close similarities ( approximately 45-60%) to that of Delta class glutathione S-transferases, but had only 14% identity to Bla g 5 [17].

Analytical, diagnostic and therapeutic context of PSMB6


  1. Comprehensive investigation of the molecular defect in vif-deficient human immunodeficiency virus type 1 virions. Gaddis, N.C., Chertova, E., Sheehy, A.M., Henderson, L.E., Malim, M.H. J. Virol. (2003) [Pubmed]
  2. Variation of binocular-vertical fusion amplitude with convergence. Bharadwaj, S.R., Hoenig, M.P., Sivaramakrishnan, V.C., Karthikeyan, B., Simonian, D., Mau, K., Rastani, S., Schor, C.M. Invest. Ophthalmol. Vis. Sci. (2007) [Pubmed]
  3. A common autoepitope near the carboxyl terminus of the 60-kD Ro ribonucleoprotein: sequence similarity with a viral protein. Scofield, R.H., Dickey, W.D., Jackson, K.W., James, J.A., Harley, J.B. J. Clin. Immunol. (1991) [Pubmed]
  4. Spreading of the immune response from 52 kDaRo and 60 kDaRo to calreticulin in experimental autoimmunity. Kinoshita, G., Keech, C.L., Sontheimer, R.D., Purcell, A., McCluskey, J., Gordon, T.P. Lupus (1998) [Pubmed]
  5. A subset of hY RNAs is associated with erythrocyte Ro ribonucleoproteins. O'Brien, C.A., Harley, J.B. EMBO J. (1990) [Pubmed]
  6. Rapid nucleolytic degradation of the small cytoplasmic Y RNAs during apoptosis. Rutjes, S.A., van der Heijden, A., Utz, P.J., van Venrooij, W.J., Pruijn, G.J. J. Biol. Chem. (1999) [Pubmed]
  7. The human Y4 small cytoplasmic RNA gene is controlled by upstream elements and resides on chromosome 7 with all other hY scRNA genes. Maraia, R.J., Sasaki-Tozawa, N., Driscoll, C.T., Green, E.D., Darlington, G.J. Nucleic Acids Res. (1994) [Pubmed]
  8. Impact of National Schistosomiasis Control Program in Kafr El-Sheikh governorate, Nile Delta, Egypt: an independent evaluation. Barakat, R., Farghaly, A., El Morshedy, H., Hassan, M., Miller, d.e. .W. The Journal of the Egyptian Public Health Association (1998) [Pubmed]
  9. Gene expression profile changes in NB4 cells induced by arsenic trioxide. Wang, H.Y., Liu, S.X., Zhang, M. Acta Pharmacol. Sin. (2003) [Pubmed]
  10. Association of hY4 pseudogenes with Alu repeats and abundance of hY RNA-like sequences in the human genome. O'Brien, C.A., Harley, J.B. Gene (1992) [Pubmed]
  11. Anti-TS1-RNA: characterization of novel antibodies against sequence-specific RNA by random RNA selection in patients with Sjögren's syndrome. Hirokawa, K., Takasaki, Y., Takeuchi, K., Kaneda, K., Ikeda, K., Hashimoto, H. J. Rheumatol. (2002) [Pubmed]
  12. Ro RNP associated Y RNAs are highly conserved among mammals. Pruijn, G.J., Wingens, P.A., Peters, S.L., Thijssen, J.P., van Venrooij, W.J. Biochim. Biophys. Acta (1993) [Pubmed]
  13. alpha4 and beta2 integrins have nonredundant roles for asthma development, but for optimal allergen sensitization only alpha4 is critical. Banerjee, E.R., Jiang, Y., Henderson, W.R., Scott, L.M., Papayannopoulou, T. Exp. Hematol. (2007) [Pubmed]
  14. Distribution and diversity of tetracycline resistance genes encoding ribosomal protection proteins in Mekong river sediments in Vietnam. Kobayashi, T., Suehiro, F., Cach Tuyen, B., Suzuki, S. FEMS Microbiol. Ecol. (2007) [Pubmed]
  15. New Indole Alkaloids from Amsonia sinensis. Liu, H.M., Wu, B., Zheng, Q.T., Feng, X.Z. Planta Med. (1991) [Pubmed]
  16. Study on the Alkaloids of Melodinus tenuicaudatus. Zhou, Y.L., Ye, J.H., Li, Z.M., Huang, Z.H. Planta Med. (1988) [Pubmed]
  17. Purification and cloning of a Delta class glutathione S-transferase displaying high peroxidase activity isolated from the German cockroach Blattella germanica. Ma, B., Chang, F.N. FEBS J. (2007) [Pubmed]
  18. The recognition of human 60-kDa Ro ribonucleoprotein particles by antibodies associated with cutaneous lupus and neonatal lupus. Lee, L.A., Alvarez, K., Gross, T., Harley, J.B. J. Invest. Dermatol. (1996) [Pubmed]
  19. Heterogeneity of human Ro ribonucleoproteins (RNPS): nuclear retention of Ro RNPS containing the human hY5 RNA in human and mouse cells. Gendron, M., Roberge, D., Boire, G. Clin. Exp. Immunol. (2001) [Pubmed]
  20. Environmental degradation of polluting aromatic and aliphatic hydrocarbons: a case study. Osuji, L.C., Ozioma, A. Chem. Biodivers. (2007) [Pubmed]
  21. Abdominal ultra sonographic findings detected in the course of a hepatitis survey in an Egyptian rural area. El-Sharkawy, M.S., Faris, R., Grumbach, K., Edelman, R., Clemens, J., Rao, M., Darwish, M. The Journal of the Egyptian Public Health Association (1998) [Pubmed]
WikiGenes - Universities