The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Rab1  -  RAB1, member RAS oncogene family

Mus musculus

Synonyms: Gtbp, Rab-1, Rab1A, Ras-related protein Rab-1A, YPT1-related protein, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Rab1

 

High impact information on Rab1

  • Several GTP binding proteins, including EF-Tu, Ypt1, rab-5, and FtsY, and adenylosuccinate synthetase have been reported to bind xanthine nucleotides when the conserved aspartate residue in the NKXD motif was changed to asparagine [3].
  • We also show that Bet3 acts after COPII but before Rab1, alpha-SNAP and the EGTA-sensitive stage during ER-Golgi transport [4].
  • Nucleotide sequence of a gene encoding a YPT1-related protein from Schizosaccharomyces pombe [5].
  • As judged by their colabeling with antibodies to E and to Rab-1, a marker for the intermediate compartment and endoplasmic reticulum, the E protein accumulates in and induces curvature into these pre-Golgi membranes where coronaviruses have been shown earlier to assemble by budding [6].
  • Comparison of the deduced amino acid sequences with available sequences from the EMBL/Data Bank revealed that LS-Rab1 and LS-Rab2 show a sequence identity of 89-90% to the mammalian Rab1 and Rab2 proteins, and can therefore be regarded as the L. stagnalis homologs [7].
 

Anatomical context of Rab1

 

Analytical, diagnostic and therapeutic context of Rab1

References

  1. YAC contigs of the Rab1 and wobbler (wr) spinal muscular atrophy gene region on proximal mouse chromosome 11 and of the homologous region on human chromosome 2p. Wedemeyer, N., Lengeling, A., Ronsiek, M., Korthaus, D., Baer, K., Wuttke, M., Jockusch, H. Genomics (1996) [Pubmed]
  2. Analysis of Rab1 recruitment to vacuoles containing Legionella pneumophila. Kagan, J.C., Murata, T., Roy, C.R. Meth. Enzymol. (2005) [Pubmed]
  3. Characterization of a Goalpha mutant that binds xanthine nucleotides. Yu, B., Slepak, V.Z., Simon, M.I. J. Biol. Chem. (1997) [Pubmed]
  4. Mammalian Bet3 functions as a cytosolic factor participating in transport from the ER to the Golgi apparatus. Loh, E., Peter, F., Subramaniam, V.N., Hong, W. J. Cell. Sci. (2005) [Pubmed]
  5. Nucleotide sequence of a gene encoding a YPT1-related protein from Schizosaccharomyces pombe. Fawell, E., Hook, S., Armstrong, J. Nucleic Acids Res. (1989) [Pubmed]
  6. Characterization of the coronavirus mouse hepatitis virus strain A59 small membrane protein E. Raamsman, M.J., Locker, J.K., de Hooge, A., de Vries, A.A., Griffiths, G., Vennema, H., Rottier, P.J. J. Virol. (2000) [Pubmed]
  7. Isolation and characterization of three cDNAs coding for Rab proteins from the albumen gland of the mollusc Lymnaea stagnalis. Agterberg, M., van Die, I., Yang, H., Andriessen, J.A., van Tetering, A., van den Eijnden, D.H., Ploegh, H.L. Eur. J. Biochem. (1993) [Pubmed]
  8. Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Cooper, A.A., Gitler, A.D., Cashikar, A., Haynes, C.M., Hill, K.J., Bhullar, B., Liu, K., Xu, K., Strathearn, K.E., Liu, F., Cao, S., Caldwell, K.A., Caldwell, G.A., Marsischky, G., Kolodner, R.D., Labaer, J., Rochet, J.C., Bonini, N.M., Lindquist, S. Science (2006) [Pubmed]
  9. Molecular cloning and structural analysis of genes from Zea mays (L.) coding for members of the ras-related ypt gene family. Palme, K., Diefenthal, T., Vingron, M., Sander, C., Schell, J. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
 
WikiGenes - Universities