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Gene Review

Rab1  -  RAB1, member RAS oncogene family

Mus musculus

Synonyms: Gtbp, Rab-1, Rab1A, Ras-related protein Rab-1A, YPT1-related protein, ...
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Disease relevance of Rab1


High impact information on Rab1

  • Several GTP binding proteins, including EF-Tu, Ypt1, rab-5, and FtsY, and adenylosuccinate synthetase have been reported to bind xanthine nucleotides when the conserved aspartate residue in the NKXD motif was changed to asparagine [3].
  • We also show that Bet3 acts after COPII but before Rab1, alpha-SNAP and the EGTA-sensitive stage during ER-Golgi transport [4].
  • Nucleotide sequence of a gene encoding a YPT1-related protein from Schizosaccharomyces pombe [5].
  • As judged by their colabeling with antibodies to E and to Rab-1, a marker for the intermediate compartment and endoplasmic reticulum, the E protein accumulates in and induces curvature into these pre-Golgi membranes where coronaviruses have been shown earlier to assemble by budding [6].
  • Comparison of the deduced amino acid sequences with available sequences from the EMBL/Data Bank revealed that LS-Rab1 and LS-Rab2 show a sequence identity of 89-90% to the mammalian Rab1 and Rab2 proteins, and can therefore be regarded as the L. stagnalis homologs [7].

Anatomical context of Rab1


Analytical, diagnostic and therapeutic context of Rab1


  1. YAC contigs of the Rab1 and wobbler (wr) spinal muscular atrophy gene region on proximal mouse chromosome 11 and of the homologous region on human chromosome 2p. Wedemeyer, N., Lengeling, A., Ronsiek, M., Korthaus, D., Baer, K., Wuttke, M., Jockusch, H. Genomics (1996) [Pubmed]
  2. Analysis of Rab1 recruitment to vacuoles containing Legionella pneumophila. Kagan, J.C., Murata, T., Roy, C.R. Meth. Enzymol. (2005) [Pubmed]
  3. Characterization of a Goalpha mutant that binds xanthine nucleotides. Yu, B., Slepak, V.Z., Simon, M.I. J. Biol. Chem. (1997) [Pubmed]
  4. Mammalian Bet3 functions as a cytosolic factor participating in transport from the ER to the Golgi apparatus. Loh, E., Peter, F., Subramaniam, V.N., Hong, W. J. Cell. Sci. (2005) [Pubmed]
  5. Nucleotide sequence of a gene encoding a YPT1-related protein from Schizosaccharomyces pombe. Fawell, E., Hook, S., Armstrong, J. Nucleic Acids Res. (1989) [Pubmed]
  6. Characterization of the coronavirus mouse hepatitis virus strain A59 small membrane protein E. Raamsman, M.J., Locker, J.K., de Hooge, A., de Vries, A.A., Griffiths, G., Vennema, H., Rottier, P.J. J. Virol. (2000) [Pubmed]
  7. Isolation and characterization of three cDNAs coding for Rab proteins from the albumen gland of the mollusc Lymnaea stagnalis. Agterberg, M., van Die, I., Yang, H., Andriessen, J.A., van Tetering, A., van den Eijnden, D.H., Ploegh, H.L. Eur. J. Biochem. (1993) [Pubmed]
  8. Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Cooper, A.A., Gitler, A.D., Cashikar, A., Haynes, C.M., Hill, K.J., Bhullar, B., Liu, K., Xu, K., Strathearn, K.E., Liu, F., Cao, S., Caldwell, K.A., Caldwell, G.A., Marsischky, G., Kolodner, R.D., Labaer, J., Rochet, J.C., Bonini, N.M., Lindquist, S. Science (2006) [Pubmed]
  9. Molecular cloning and structural analysis of genes from Zea mays (L.) coding for members of the ras-related ypt gene family. Palme, K., Diefenthal, T., Vingron, M., Sander, C., Schell, J. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
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