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Gene Review:

Cxcl15 - chemokine (C-X-C motif) ligand 15

Mus musculus

Synonyms: C-X-C motif chemokine 15, Il8, Lungkine, Scyb15, Small-inducible cytokine B15, ...

Ohneda, O. et al., Chen, S.C. et al., Rossi, D.L. et al., Zhao, J. et al.

Ohneda, Ohneda, Nomiyama, Zheng, Gold, Arai, Miyamoto, Taillon, McIndoe, Shimkets, Lewin, Suda, Lasky,

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Disease relevance of Cxcl15

However, Lungkine null mice were more susceptible to Klebsiella pneumonia infection, with a decreased survival and increased lung bacterial burden compared with infected wild-type mice [1].

High impact information on Cxcl15

We utilized a differential gene expression method to isolate a chemokine, termed WECHE, from one of these cell lines [2].
WECHE was also chemotactic for bone marrow cells [2].
WECHE reduced HPP-CFC production from fetal liver-derived stem cells [2].
WECHE inhibited the formation of erythroid cells but had no effect on either myeloid or B cell formation [2].
WECHE hindered the growth of yolk sac-derived endothelial cells [2].

Biological context of Cxcl15

Using fluorescent in situ hybridization, we show that Lungkine maps to mouse chromosome 5 [3].
Increased lungkine and chitinase levels in allergic airway inflammation: a proteomics approach [4].

Anatomical context of Cxcl15

WECHE repressed BFU-E development from either mouse fetal liver or bone marrow progenitor cells but had no effect on colony formation induced by IL-3 or IL-7 [2].
Taken together, these findings demonstrate that Lungkine is an important mediator of neutrophil migration from the lung parenchyma into the airspace [1].

Analytical, diagnostic and therapeutic context of Cxcl15

High levels of Lungkine mRNA were specifically detected in the lung and at lower levels in fetal lung tissue by Northern blot and in situ hybridization, suggesting a potential role for this chemokine during lung development [3].

References

Impaired pulmonary host defense in mice lacking expression of the CXC chemokine lungkine. Chen, S.C., Mehrad, B., Deng, J.C., Vassileva, G., Manfra, D.J., Cook, D.N., Wiekowski, M.T., Zlotnik, A., Standiford, T.J., Lira, S.A. J. Immunol. (2001) [Pubmed]
WECHE: a novel hematopoietic regulatory factor. Ohneda, O., Ohneda, K., Nomiyama, H., Zheng, Z., Gold, S.A., Arai, F., Miyamoto, T., Taillon, B.E., McIndoe, R.A., Shimkets, R.A., Lewin, D.A., Suda, T., Lasky, L.A. Immunity (2000) [Pubmed]
Lungkine, a novel CXC chemokine, specifically expressed by lung bronchoepithelial cells. Rossi, D.L., Hurst, S.D., Xu, Y., Wang, W., Menon, S., Coffman, R.L., Zlotnik, A. J. Immunol. (1999) [Pubmed]
Increased lungkine and chitinase levels in allergic airway inflammation: a proteomics approach. Zhao, J., Zhu, H., Wong, C.H., Leung, K.Y., Wong, W.S. Proteomics (2005) [Pubmed]

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