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Gene Review

STX3  -  syntaxin 3

Homo sapiens

Synonyms: STX3A, Syntaxin-3
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High impact information on STX3


Biological context of STX3

  • We suggest that TI-VAMP, SNAP23, and syntaxin 3 can participate in exocytotic processes at the apical plasma membrane of epithelial cells and, more generally, domain-specific exocytosis in clostridial NT-resistant pathways [4].
  • This apical localization was confirmed by confocal microscopy after transfection of the cDNA coding for either full length or N-terminally truncated human syntaxin 3 in Caco-2 cells [5].
  • Functionally, co-expression of BKCa channels with syntaxin 1A, but not syntaxin 3, was observed to enhance channel gating and kinetics at low concentrations (1-4 microM) of free cytosolic calcium, but not at higher concentrations (< or = 10 microM), as judged by macroscopic current recordings in excised membrane patches [6].
  • RESULTS: We have identified and purified a novel binding partner of syntaxin-3 from rat lung, and isolated and sequenced the cDNA of its human homologue from a human brain cDNA library [7].
  • Introduction of a point mutation into syntaxin 3 abolishes its polarized distribution and causes PSMA to be targeted in a nonpolarized fashion [8].

Anatomical context of STX3


Associations of STX3 with chemical compounds


Physical interactions of STX3


Regulatory relationships of STX3


Other interactions of STX3


Analytical, diagnostic and therapeutic context of STX3


  1. Syntaxins 3 and 4 are concentrated in separate clusters on the plasma membrane before the establishment of cell polarity. Low, S.H., Vasanji, A., Nanduri, J., He, M., Sharma, N., Koo, M., Drazba, J., Weimbs, T. Mol. Biol. Cell (2006) [Pubmed]
  2. Protease-activated receptor-1 activation of endothelial cells induces protein kinase Calpha-dependent phosphorylation of syntaxin 4 and Munc18c: role in signaling p-selectin expression. Fu, J., Naren, A.P., Gao, X., Ahmmed, G.U., Malik, A.B. J. Biol. Chem. (2005) [Pubmed]
  3. The role of syntaxins in the specificity of vesicle targeting in polarized epithelial cells. ter Beest, M.B., Chapin, S.J., Avrahami, D., Mostov, K.E. Mol. Biol. Cell (2005) [Pubmed]
  4. A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells. Galli, T., Zahraoui, A., Vaidyanathan, V.V., Raposo, G., Tian, J.M., Karin, M., Niemann, H., Louvard, D. Mol. Biol. Cell (1998) [Pubmed]
  5. Human syntaxin 3 is localized apically in human intestinal cells. Delgrossi, M.H., Breuza, L., Mirre, C., Chavrier, P., Le Bivic, A. J. Cell. Sci. (1997) [Pubmed]
  6. Syntaxin 1A co-associates with native rat brain and cloned large conductance, calcium-activated potassium channels in situ. Ling, S., Sheng, J.Z., Braun, J.E., Braun, A.P. J. Physiol. (Lond.) (2003) [Pubmed]
  7. Taxilin; a novel syntaxin-binding protein that is involved in Ca2+-dependent exocytosis in neuroendocrine cells. Nogami, S., Satoh, S., Nakano, M., Shimizu, H., Fukushima, H., Maruyama, A., Terano, A., Shirataki, H. Genes Cells (2003) [Pubmed]
  8. Differing effects of microtubule depolymerizing and stabilizing chemotherapeutic agents on t-SNARE-mediated apical targeting of prostate-specific membrane antigen. Christiansen, J.J., Weimbs, T., Bander, N., Rajasekaran, A.K. Mol. Cancer Ther. (2006) [Pubmed]
  9. Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3. Darios, F., Davletov, B. Nature (2006) [Pubmed]
  10. Munc18-2, a functional partner of syntaxin 3, controls apical membrane trafficking in epithelial cells. Riento, K., Kauppi, M., Keranen, S., Olkkonen, V.M. J. Biol. Chem. (2000) [Pubmed]
  11. Interaction of Munc-18-2 with syntaxin 3 controls the association of apical SNAREs in epithelial cells. Riento, K., Galli, T., Jansson, S., Ehnholm, C., Lehtonen, E., Olkkonen, V.M. J. Cell. Sci. (1998) [Pubmed]
  12. Splenic endothelial cell lines support development of dendritic cells from bone marrow. Despars, G., O'Neill, H.C. Stem Cells (2006) [Pubmed]
  13. Heterogeneity amongst splenic stromal cell lines which support dendritic cell hematopoiesis. Despars, G., O'Neill, H.C. In Vitro Cell. Dev. Biol. Anim. (2006) [Pubmed]
  14. Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells. Bared, S.M., Buechler, C., Boettcher, A., Dayoub, R., Sigruener, A., Grandl, M., Rudolph, C., Dada, A., Schmitz, G. Mol. Biol. Cell (2004) [Pubmed]
  15. Interaction of syntaxins with the amiloride-sensitive epithelial sodium channel. Saxena, S., Quick, M.W., Tousson, A., Oh, Y., Warnock, D.G. J. Biol. Chem. (1999) [Pubmed]
  16. Analysis of the Munc18b-syntaxin binding interface. Use of a mutant Munc18b to dissect the functions of syntaxins 2 and 3. Kauppi, M., Wohlfahrt, G., Olkkonen, V.M. J. Biol. Chem. (2002) [Pubmed]
  17. Regulation of the amiloride-sensitive epithelial sodium channel by syntaxin 1A. Qi, J., Peters, K.W., Liu, C., Wang, J.M., Edinger, R.S., Johnson, J.P., Watkins, S.C., Frizzell, R.A. J. Biol. Chem. (1999) [Pubmed]
  18. Involvement of syntaxin 4 in the transport of membrane-type 1 matrix metalloproteinase to the plasma membrane in human gastric epithelial cells. Miyata, T., Ohnishi, H., Suzuki, J., Yoshikumi, Y., Ohno, H., Mashima, H., Yasuda, H., Ishijima, T., Osawa, H., Satoh, K., Sunada, K., Kita, H., Yamamoto, H., Sugano, K. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
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