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Gene Review

Tfec  -  transcription factor EC

Mus musculus

Synonyms: BB107417, TFE-C, TFEC, Tcfec, Transcription factor EC, ...
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High impact information on Tcfec

  • These genes included a transcription factor controlling pigmentation, Mitf, and the related factor Tfec (Tcfec -- Mouse Genome Informatics), which can activate a melanogenic gene expression program [1].
  • IL-4, however, induced a rapid, but long-lasting, increase in Tfec mRNA, which, in contrast to LPS stimulation, also resulted in detectable levels of Tfec protein [2].
  • A global comparison of IL-4-induced genes in both wild-type and Tfec mutant macrophages revealed a surprisingly mild phenotype with only a few genes affected by Tfec deficiency [2].
  • LPS induced a rapid and transient up-regulation of Tfec mRNA expression and promoter activity, which was dependent on a functional NF-kappaB site [2].
  • However, mice lacking Tfec develop normally, indicating a redundant role for Tfec in myeloid cell development [2].

Biological context of Tcfec

  • A 600-bp fragment of the TATA-less putative proximal promoter of TFEC shares features with many known macrophage-specific promoters and preferentially directs luciferase expression in the RAW264.7 macrophage cell line in transient transfection assays [3].

Anatomical context of Tcfec

  • The murine homologue of the TFEC was cloned as part of an analysis of the expression of the microphthalmia-TFE (MiT) subfamily of transcription factors in macrophages [3].
  • TFEC, which most likely acts as a transcriptional repressor in heterodimers with other MiT family members, was identified in cells of the mononuclear phagocyte lineage, coexpressed with all other known MiT subfamily members (Mitf, TFE3, TFEB) [3].

Associations of Tcfec with chemical compounds

  • Metabolism of the common industrial gas tetrafluoroethylene in mammals results in the formation of S-(1,1,2,2)-tetrafluoroethyl-L-cysteine (TFEC), which can be bioactivated by a mitochondrial C-S lyase commonly referred to as beta-lyase [4].

Other interactions of Tcfec

  • TFEC is a macrophage-restricted member of the microphthalmia-TFE subfamily of basic helix-loop-helix leucine zipper transcription factors [3].


  1. Transdifferentiation of the retina into pigmented cells in ocular retardation mice defines a new function of the homeodomain gene Chx10. Rowan, S., Chen, C.M., Young, T.L., Fisher, D.E., Cepko, C.L. Development (2004) [Pubmed]
  2. Transcription factor Tfec contributes to the IL-4-inducible expression of a small group of genes in mouse macrophages including the granulocyte colony-stimulating factor receptor. Rehli, M., Sulzbacher, S., Pape, S., Ravasi, T., Wells, C.A., Heinz, S., Söllner, L., El Chartouni, C., Krause, S.W., Steingrimsson, E., Hume, D.A., Andreesen, R. J. Immunol. (2005) [Pubmed]
  3. TFEC is a macrophage-restricted member of the microphthalmia-TFE subfamily of basic helix-loop-helix leucine zipper transcription factors. Rehli, M., Lichanska, A., Cassady, A.I., Ostrowski, M.C., Hume, D.A. J. Immunol. (1999) [Pubmed]
  4. Mitochondrial aconitase modification, functional inhibition, and evidence for a supramolecular complex of the TCA cycle by the renal toxicant S-(1,1,2,2-tetrafluoroethyl)-L-cysteine. James, E.A., Gygi, S.P., Adams, M.L., Pierce, R.H., Fausto, N., Aebersold, R.H., Nelson, S.D., Bruschi, S.A. Biochemistry (2002) [Pubmed]
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