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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Informatics


Psychiatry related information on Informatics


High impact information on Informatics

  • These genes included a transcription factor controlling pigmentation, Mitf, and the related factor Tfec (Tcfec -- Mouse Genome Informatics), which can activate a melanogenic gene expression program [5].
  • NeuroD (Neurod1 - Mouse Genome Informatics) expression in the lung was detected in the adult, and was enhanced in the fetal lungs of Hes1-null mice [6].
  • In this study we found, using lipid mediator informatics employing liquid chromatography-tandem mass spectrometry, that (10,17S)-docosatriene/neuroprotectin D1, now termed protectin D1 (PD1), is generated from docosahexaenoic acid by T helper type 2-skewed peripheral blood mononuclear cells in a lipoxygenase-dependent manner [7].
  • Using this informatics strategy we have characterized post-mitotic reestablishment of focal subnuclear organization of Runx (AML/Cbfa) transcription factors in progeny cells [8].
  • The complexity of the p53 response makes this an ideal system for application of newly emerging rapid throughput analysis techniques and informatics analysis [9].

Biological context of Informatics


Associations of Informatics with chemical compounds

  • In this contribution both the EDUCTRA project of the European Advanced Informatics in Medicine Programme and the IT-EDUCTRA project of the Telematics Applications Programme (Health Sector) are described [14].
  • In this paper, the author describes an imaginary informatics curriculum made up of six core courses: Introduction to Complexity, Decisions and Outcomes, Scarcity and Conflict, Teamwork and Organizations, Representing Knowledge and Action, and Groupware and Collaboration [15].
  • This paper examines the structure and process of the Nursing Terminology Summit using concepts, principles, theories, and strategies identified in Lorenzi and Riley [Organizational Aspects of Health Informatics: Managing Technological Change, Springer, 1995] [16].
  • ORATEL is a 3-year project of which WHO/EURO is prime partner and which is partially supported financially by the Advanced Informatics in Medicine programme of the Commission of the Europe Communities [17].
  • Metropolis redux: the unique importance of library skills in informatics [18].

Gene context of Informatics

  • Using SAGE informatics, we found 21 genes with a high positive correlation to S100A7 expression in libraries representing different categories of tissues archived at SAGE Genie, suggesting a function of psoriasin that is not tissue specific [19].
  • We highlight the value of evolutionary informatics and set the stage for dissecting out potential subtle differences in TSHR function associated with structural variations [20].
  • The CGAP web site ( provides informatics tools for in silico analysis of the CGAP datasets as well as information for accessing each of the CGAP resources [21].
  • We have devised and implemented in PrISM (protein informatics system for modeling) a new measure of protein structural relationships, the protein structural distance (PSD) [22].
  • Changes in all aspects of HTS from compound management through to evaluation of hits and leads, strengthened by infrastructure improvements, in both automation and informatics, have made possible increased analysis and implementation of process and quality control throughout HTS [23].


  1. Transcription factor AP-2gamma is essential in the extra-embryonic lineages for early postimplantation development. Auman, H.J., Nottoli, T., Lakiza, O., Winger, Q., Donaldson, S., Williams, T. Development (2002) [Pubmed]
  2. Genomics of the marA/soxS/rob regulon of Escherichia coli: identification of directly activated promoters by application of molecular genetics and informatics to microarray data. Martin, R.G., Rosner, J.L. Mol. Microbiol. (2002) [Pubmed]
  3. Health informatics and modernisation: bridging the gap. Cowley, C., Daws, L., Ellis, B. Informatics in primary care. (2003) [Pubmed]
  4. Variables influencing career choices of graduates of informatics programs funded by the National Library of Medicine. Braude, R.M. Academic medicine : journal of the Association of American Medical Colleges. (1990) [Pubmed]
  5. Transdifferentiation of the retina into pigmented cells in ocular retardation mice defines a new function of the homeodomain gene Chx10. Rowan, S., Chen, C.M., Young, T.L., Fisher, D.E., Cepko, C.L. Development (2004) [Pubmed]
  6. Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium. Ito, T., Udaka, N., Yazawa, T., Okudela, K., Hayashi, H., Sudo, T., Guillemot, F., Kageyama, R., Kitamura, H. Development (2000) [Pubmed]
  7. The docosatriene protectin D1 is produced by TH2 skewing and promotes human T cell apoptosis via lipid raft clustering. Ariel, A., Li, P.L., Wang, W., Tang, W.X., Fredman, G., Hong, S., Gotlinger, K.H., Serhan, C.N. J. Biol. Chem. (2005) [Pubmed]
  8. Quantitative signature for architectural organization of regulatory factors using intranuclear informatics. Young, D.W., Zaidi, S.K., Furcinitti, P.S., Javed, A., van Wijnen, A.J., Stein, J.L., Lian, J.B., Stein, G.S. J. Cell. Sci. (2004) [Pubmed]
  9. Roles for p53 in growth arrest and apoptosis: putting on the brakes after genotoxic stress. Amundson, S.A., Myers, T.G., Fornace, A.J. Oncogene (1998) [Pubmed]
  10. KEGG as a glycome informatics resource. Hashimoto, K., Goto, S., Kawano, S., Aoki-Kinoshita, K.F., Ueda, N., Hamajima, M., Kawasaki, T., Kanehisa, M. Glycobiology (2006) [Pubmed]
  11. A national agenda for public health informatics: summarized recommendations from the 2001 AMIA Spring Congress. Yasnoff, W.A., Overhage, J.M., Humphreys, B.L., LaVenture, M. Journal of the American Medical Informatics Association : JAMIA. (2001) [Pubmed]
  12. Genetics of rheumatoid arthritis: confronting complexity. Gregersen, P.K. Arthritis Res. (1999) [Pubmed]
  13. Observers' report. Hartley, D.S. Psychopharmacology bulletin. (1998) [Pubmed]
  14. Education and training in health informatics: the IT-EDUCTRA project. Hasman, A. International journal of medical informatics. (1998) [Pubmed]
  15. Re-imagining the medical informatics curriculum. Frisse, M.E. Academic medicine : journal of the Association of American Medical Colleges. (1997) [Pubmed]
  16. The Nursing Terminology Summit Conferences: a case study of successful collaboration for change. Ozbolt, J. Journal of biomedical informatics. (2003) [Pubmed]
  17. The ORATEL project. Telematic system for quality assurance in oral health care. Petersen, P.E., Christensen, L.B., Johansen, K.S. Studies in health technology and informatics. (1994) [Pubmed]
  18. Metropolis redux: the unique importance of library skills in informatics. King, S.B., MacDonald, K. Journal of the Medical Library Association : JMLA. (2004) [Pubmed]
  19. Cluster analysis of S100 gene expression and genes correlating to psoriasin (S100A7) expression at different stages of breast cancer development. Carlsson, H., Petersson, S., Enerbäck, C. Int. J. Oncol. (2005) [Pubmed]
  20. Evolution of the thyrotropin receptor: a G protein coupled receptor with an intrinsic capacity to dimerize. Kaczur, V., Puskás, L.G., Takács, M., Rácz, I.A., Szendroi, A., Tóth, S., Nagy, Z., Szalai, C., Balázs, C., Falus, A., Knudsen, B., Farid, N.R. Mol. Genet. Metab. (2003) [Pubmed]
  21. The Cancer Genome Anatomy Project: new resources for reading the molecular signatures of cancer. Strausberg, R.L. J. Pathol. (2001) [Pubmed]
  22. An integrated approach to the analysis and modeling of protein sequences and structures. I. Protein structural alignment and a quantitative measure for protein structural distance. Yang, A.S., Honig, B. J. Mol. Biol. (2000) [Pubmed]
  23. HTS quality control and data analysis: a process to maximize information from a high-throughput screen. Padmanabha, R., Cook, L., Gill, J. Comb. Chem. High Throughput Screen. (2005) [Pubmed]
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