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Gene Review:

HNRNPA3 - heterogeneous nuclear ribonucleoprotein A3

Homo sapiens

Synonyms: 2610510D13Rik, D10S102, FBRNP, HNRPA3, Heterogeneous nuclear ribonucleoprotein A3, ...

Ma, A.S. et al., Moir, D.T. et al., Tokino, T. et al., Inazawa, J. et al., Makeyev, A.V. et al., et al.

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Disease relevance of HNRPA3

We have constructed a long-range contig of cosmid and YAC clones around D10S102, a locus that is tightly linked to the gene responsible for multiple endocrine neoplasia type 2A (MEN2A) [1].
Furthermore, using this prophase ordering system, we confirmed the linear order and defined the orientation of seven cosmid markers within a 360-kb region surrounding D10S102, a locus that is closely linked to the disease locus in families segregating an allele causing multiple endocrine neoplasia IIA (MEN2A) [2].

High impact information on HNRPA3

No recombination was observed between the MEN2A locus and either of the four loci D10Z1 (lod score 12.79), D10S102 (lod score 6.38), D10S94 (lod score 7.76), and D10S34 (lod score 5.94) [3].
In Western blotting, 38-, 39-, 41-, and 41.5-kDa components were all recognized by antibodies against a peptide in the glycine-rich region of hnRNP A3, but only the 41- and 41.5-kDa bands bound antibodies to a 15-residue N-terminal peptide encoded by an alternatively spliced part of exon 1 [4].
Four YACs carrying a RET sequence-tagged site (STS) and two YACs carrying a D10S102 STS were used to initiate chromosome walks [5].
An overlapping set of 21 yeast artificial chromosomes (YACs) spanning the RET proto-oncogene [Takahashi et al., Oncogene 3 (1988) 571-578] and D10S102 markers on human chromosome 10 was isolated in a series of hybridization-based chromosomal walks in a YAC library [5].
With D10S102 as a starting point, a 360-kb cosmid contig was constructed by bidirectional genomic walking, and at least six fragments from these cosmids showed high sequence homology to other species [1].

Biological context of HNRPA3

We demonstrate that the sequence reported previously as the human hnRNP A3 gene (Accession number S63912) and located on 10p11.1 belongs to a processed pseudogene of the functional intron-containing locus HNRPA3, which we have identified on 2q31 [6].
We previously reported a nearly 1-Mb contig of cosmid and YAC clones at D10S102, a locus that is tightly linked to the gene responsible for multiple endocrine neoplasia type 2 (MEN2A) [7].

Analytical, diagnostic and therapeutic context of HNRPA3

Mutational analysis and confocal microscopy data support the hypothesis that the hnRNP A3 isoforms have a role in cytoplasmic trafficking of RNA [4].
Sequence-specific binding of bacterially expressed hnRNP A3 to A2RE has been demonstrated by biosensor and UV cross-linking electrophoretic mobility shift assays [4].

References

Physical mapping of a 950-kb region surrounding a locus (D10S102) tightly linked to the MEN2A gene. Tokino, T., Imai, T., Tanigami, A., Takiguchi, S., Nakamura, Y. Genomics (1992) [Pubmed]
High resolution ordering of DNA markers by multi-color fluorescent in situ hybridization of prophase chromosomes. Inazawa, J., Ariyama, T., Tokino, T., Tanigami, A., Nakamura, Y., Abe, T. Cytogenet. Cell Genet. (1994) [Pubmed]
Genetic analysis of 24 French families with multiple endocrine neoplasia type 2A. Narod, S.A., Lavoué, M.F., Morgan, K., Calmettes, C., Sobol, H., Goodfellow, P.J., Lenoir, G.M. Am. J. Hum. Genet. (1992) [Pubmed]
Heterogeneous nuclear ribonucleoprotein A3, a novel RNA trafficking response element-binding protein. Ma, A.S., Moran-Jones, K., Shan, J., Munro, T.P., Snee, M.J., Hoek, K.S., Smith, R. J. Biol. Chem. (2002) [Pubmed]
Rapid identification of overlapping YACs in the MEN2 region of human chromosome 10 by hybridization with Alu element-mediated PCR products. Moir, D.T., Dorman, T.E., Xue, F., Ma, N.S., Stanton, V.P., Housman, D., Bowden, D.W., Noll, W.W., Mao, J. Gene (1993) [Pubmed]
HnRNP A3 genes and pseudogenes in the vertebrate genomes. Makeyev, A.V., Kim, C.B., Ruddle, F.H., Enkhmandakh, B., Erdenechimeg, L., Bayarsaihan, D. J. Exp. Zoolog. Part A Comp. Exp. Biol. (2005) [Pubmed]
Identification and characterization of a cDNA, which is highly homologous to the ribonucleoprotein gene, from a locus (D10S102) closely linked to MEN2 (multiple endocrine neoplasia type 2). Takiguchi, S., Tokino, T., Imai, T., Tanigami, A., Koyama, K., Nakamura, Y. Cytogenet. Cell Genet. (1993) [Pubmed]

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