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Gene Review

Mkl1  -  MKL (megakaryoblastic leukemia)/myocardin...

Mus musculus

Synonyms: AI852829, AMKL, AW743281, AW821984, Basic SAP coiled-coil transcription activator, ...
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Disease relevance of Mkl1


High impact information on Mkl1


  1. Increased dosage of Runx1/AML1 acts as a positive modulator of myeloid leukemogenesis in BXH2 mice. Yanagida, M., Osato, M., Yamashita, N., Liqun, H., Jacob, B., Wu, F., Cao, X., Nakamura, T., Yokomizo, T., Takahashi, S., Yamamoto, M., Shigesada, K., Ito, Y. Oncogene (2005) [Pubmed]
  2. Activating alleles of JAK3 in acute megakaryoblastic leukemia. Walters, D.K., Mercher, T., Gu, T.L., O'Hare, T., Tyner, J.W., Loriaux, M., Goss, V.L., Lee, K.A., Eide, C.A., Wong, M.J., Stoffregen, E.P., McGreevey, L., Nardone, J., Moore, S.A., Crispino, J., Boggon, T.J., Heinrich, M.C., Deininger, M.W., Polakiewicz, R.D., Gilliland, D.G., Druker, B.J. Cancer Cell (2006) [Pubmed]
  3. Acute myeloid leukemia-associated Mkl1 (Mrtf-a) is a key regulator of mammary gland function. Sun, Y., Boyd, K., Xu, W., Ma, J., Jackson, C.W., Fu, A., Shillingford, J.M., Robinson, G.W., Hennighausen, L., Hitzler, J.K., Ma, Z., Morris, S.W. Mol. Cell. Biol. (2006) [Pubmed]
  4. Requirement of a myocardin-related transcription factor for development of mammary myoepithelial cells. Li, S., Chang, S., Qi, X., Richardson, J.A., Olson, E.N. Mol. Cell. Biol. (2006) [Pubmed]
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