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Gene Review

Srf  -  serum response factor

Mus musculus

Synonyms: AW049942, AW240594, SRF, Serum response factor
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  1. Functional analysis of a growth factor-responsive transcription factor complex. Hill, C.S., Marais, R., John, S., Wynne, J., Dalton, S., Treisman, R. Cell (1993) [Pubmed]
  2. Serum response factor controls neuronal circuit assembly in the hippocampus. Knöll, B., Kretz, O., Fiedler, C., Alberti, S., Schütz, G., Frotscher, M., Nordheim, A. Nat. Neurosci. (2006) [Pubmed]
  3. Serum response factor is crucial for actin cytoskeletal organization and focal adhesion assembly in embryonic stem cells. Schratt, G., Philippar, U., Berger, J., Schwarz, H., Heidenreich, O., Nordheim, A. J. Cell Biol. (2002) [Pubmed]
  4. Acute myeloid leukemia-associated Mkl1 (Mrtf-a) is a key regulator of mammary gland function. Sun, Y., Boyd, K., Xu, W., Ma, J., Jackson, C.W., Fu, A., Shillingford, J.M., Robinson, G.W., Hennighausen, L., Hitzler, J.K., Ma, Z., Morris, S.W. Mol. Cell. Biol. (2006) [Pubmed]
  5. Serum response factor is essential for mesoderm formation during mouse embryogenesis. Arsenian, S., Weinhold, B., Oelgeschläger, M., Rüther, U., Nordheim, A. EMBO J. (1998) [Pubmed]
  6. Myocardin-related transcription factor B is required for normal mouse vascular development and smooth muscle gene expression. Wei, K., Che, N., Chen, F. Dev. Dyn. (2007) [Pubmed]
  7. Srf(-/-) ES cells display non-cell-autonomous impairment in mesodermal differentiation. Weinhold, B., Schratt, G., Arsenian, S., Berger, J., Kamino, K., Schwarz, H., Rüther, U., Nordheim, A. EMBO J. (2000) [Pubmed]
  8. Requirement for serum response factor for skeletal muscle growth and maturation revealed by tissue-specific gene deletion in mice. Li, S., Czubryt, M.P., McAnally, J., Bassel-Duby, R., Richardson, J.A., Wiebel, F.F., Nordheim, A., Olson, E.N. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  9. Myocardin is a direct transcriptional target of Mef2, Tead and Foxo proteins during cardiovascular development. Creemers, E.E., Sutherland, L.B., McAnally, J., Richardson, J.A., Olson, E.N. Development (2006) [Pubmed]
  10. Muscle-specific (CArG) and serum-responsive (SRE) promoter elements are functionally interchangeable in Xenopus embryos and mouse fibroblasts. Taylor, M., Treisman, R., Garrett, N., Mohun, T. Development (1989) [Pubmed]
  11. Muscle homeodomain protein MHox inhibits ternary complex formation at the c-fos serum response element. Ma, J.T., Ng, S.Y. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  12. Serum response factor is required for immediate-early gene activation yet is dispensable for proliferation of embryonic stem cells. Schratt, G., Weinhold, B., Lundberg, A.S., Schuck, S., Berger, J., Schwarz, H., Weinberg, R.A., Rüther, U., Nordheim, A. Mol. Cell. Biol. (2001) [Pubmed]
  13. Serum response factor p67SRF is expressed and required during myogenic differentiation of both mouse C2 and rat L6 muscle cell lines. Vandromme, M., Gauthier-Rouvière, C., Carnac, G., Lamb, N., Fernandez, A. J. Cell Biol. (1992) [Pubmed]
  14. Growth hormone stimulates phosphorylation and activation of elk-1 and expression of c-fos, egr-1, and junB through activation of extracellular signal-regulated kinases 1 and 2. Hodge, C., Liao, J., Stofega, M., Guan, K., Carter-Su, C., Schwartz, J. J. Biol. Chem. (1998) [Pubmed]
  15. RhoA signaling via serum response factor plays an obligatory role in myogenic differentiation. Wei, L., Zhou, W., Croissant, J.D., Johansen, F.E., Prywes, R., Balasubramanyam, A., Schwartz, R.J. J. Biol. Chem. (1998) [Pubmed]
  16. Serum response factor and protein-mediated DNA bending contribute to transcription of the dystrophin muscle-specific promoter. Galvagni, F., Lestingi, M., Cartocci, E., Oliviero, S. Mol. Cell. Biol. (1997) [Pubmed]
  17. Phosphorylation of serum response factor by casein kinase II: evidence against a role in growth factor regulation of fos expression. Manak, J.R., Prywes, R. Oncogene (1993) [Pubmed]
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