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MeSH Review

Leukemia, Megakaryocytic, Acute

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Disease relevance of Leukemia, Megakaryocytic, Acute


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Chemical compound and disease context of Leukemia, Megakaryocytic, Acute


Biological context of Leukemia, Megakaryocytic, Acute


Anatomical context of Leukemia, Megakaryocytic, Acute


Gene context of Leukemia, Megakaryocytic, Acute


  1. Prenatal origin of GATA1 mutations may be an initiating step in the development of megakaryocytic leukemia in Down syndrome. Taub, J.W., Mundschau, G., Ge, Y., Poulik, J.M., Qureshi, F., Jensen, T., James, S.J., Matherly, L.H., Wechsler, J., Crispino, J.D. Blood (2004) [Pubmed]
  2. JAK2 mutation 1849G>T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia. Jelinek, J., Oki, Y., Gharibyan, V., Bueso-Ramos, C., Prchal, J.T., Verstovsek, S., Beran, M., Estey, E., Kantarjian, H.M., Issa, J.P. Blood (2005) [Pubmed]
  3. Molecular cloning of two isoforms of a receptor for the human hematopoietic cytokine interleukin-11. Chérel, M., Sorel, M., Lebeau, B., Dubois, S., Moreau, J.F., Bataille, R., Minvielle, S., Jacques, Y. Blood (1995) [Pubmed]
  4. Natural history of GATA1 mutations in Down syndrome. Ahmed, M., Sternberg, A., Hall, G., Thomas, A., Smith, O., O'Marcaigh, A., Wynn, R., Stevens, R., Addison, M., King, D., Stewart, B., Gibson, B., Roberts, I., Vyas, P. Blood (2004) [Pubmed]
  5. Differential gene expression, GATA1 target genes, and the chemotherapy sensitivity of Down syndrome megakaryocytic leukemia. Ge, Y., Dombkowski, A.A., LaFiura, K.M., Tatman, D., Yedidi, R.S., Stout, M.L., Buck, S.A., Massey, G., Becton, D.L., Weinstein, H.J., Ravindranath, Y., Matherly, L.H., Taub, J.W. Blood (2006) [Pubmed]
  6. Adult acute megakaryocytic leukemia: an analysis of 37 patients treated at M.D. Anderson Cancer Center. Oki, Y., Kantarjian, H.M., Zhou, X., Cortes, J., Faderl, S., Verstovsek, S., O'Brien, S., Koller, C., Beran, M., Bekele, B.N., Pierce, S., Thomas, D., Ravandi, F., Wierda, W.G., Giles, F., Ferrajoli, A., Jabbour, E., Keating, M.J., Bueso-Ramos, C.E., Estey, E., Garcia-Manero, G. Blood (2006) [Pubmed]
  7. Differential requirements for the activation domain and FOG-interaction surface of GATA-1 in megakaryocyte gene expression and development. Muntean, A.G., Crispino, J.D. Blood (2005) [Pubmed]
  8. Hematopoietic stem cell transplantation for de novo acute megakaryocytic leukemia in first complete remission: a retrospective study of the European Group for Blood and Marrow Transplantation (EBMT). Garderet, L., Labopin, M., Gorin, N.C., Polge, E., Baruchel, A., Meloni, G., Ortega, J., Vossen, J., Bunjes, D., Leverger, G., Blaise, D., Ferrant, A., Brune, M., Dore, E., Gadner, H., Zintl, F., Yaniv, I., Dini, G., Frassoni, F. Blood (2005) [Pubmed]
  9. Transcriptional regulation of interleukin-3 expression in megakaryocytes. Nimer, S., Zhang, J., Avraham, H., Miyazaki, Y. Blood (1996) [Pubmed]
  10. IL-3 and ribavirin induce differentiation and growth suppression during long-term treatment of a megakaryocytic leukemia cell line. Majumdar, A., Kerby, S., Mullikin, B., Beckstead, J.H., Stenberg, P.E., Seidman, M.M. J. Cell. Physiol. (1995) [Pubmed]
  11. Phenotypic and genotypic heterogeneity in infant acute leukemia. II. Acute nonlymphoblastic leukemia. Köller, U., Haas, O.A., Ludwig, W.D., Bartram, C.R., Harbott, J., Panzer-Grümayer, R., Hansen-Hagge, T., Ritter, J., Creutzig, U., Knapp, W. Leukemia (1989) [Pubmed]
  12. Cytosolic calcium mobilization and thromboxane synthesis in a human megakaryocytic leukemia cell. Ryo, R., Yoshida, A., Adachi, M., Sugano, W., Yasunaga, M., Yoneda, N., Yamaguchi, N., Sato, T. Exp. Hematol. (1990) [Pubmed]
  13. Acute myelofibrosis. Immunohistochemical study of four cases and comparison with acute megakaryocytic leukemia. Hruban, R.H., Kuhajda, F.P., Mann, R.B. Am. J. Clin. Pathol. (1987) [Pubmed]
  14. Effect of arsenic trioxide on viability, proliferation, and apoptosis in human megakaryocytic leukemia cell lines. Lu, M., Levin, J., Sulpice, E., Sequeira-Le Grand, A., Alemany, M., Caen, J.P., Han, Z.C. Exp. Hematol. (1999) [Pubmed]
  15. AML1 overexpression and/or mutations should be checked in trisomy 21 patients with megakaryocytic leukemia. Huret, J.L., Léonard, C. Leukemia (2003) [Pubmed]
  16. The effects of arsenic trioxide (As2O3) on human megakaryocytic leukemia cell lines. With a comparison of its effects on other cell lineages. Alemany, M., Levin, J. Leuk. Lymphoma (2000) [Pubmed]
  17. Human stem cell factor (c-kit ligand) induces an autocrine loop of growth in a GM-CSF-dependent megakaryocytic leukemia cell line. Kiss, C., Cesano, A., Zsebö, K.M., Clark, S.C., Santoli, D. Leukemia (1993) [Pubmed]
  18. Tyrosine phosphorylation and activation of JAK family tyrosine kinases by interleukin-9 in MO7E cells. Yin, T., Yang, L., Yang, Y.C. Blood (1995) [Pubmed]
  19. Expression of the receptor MPL and proliferative effects of its ligand thrombopoietin on human leukemia cells. Quentmeier, H., Zaborski, M., Graf, G., Ludwig, W.D., Drexler, H.G. Leukemia (1996) [Pubmed]
  20. Different expression of CD36 antigen molecule on the surface of megakaryocyte lineage leukemias and megakaryocyte leukemia cell lines MEG-01 and HEL. Imamura, N., Mtasiwa, D.M., Inada, T., Kuramoto, A. Leukemia (1990) [Pubmed]
  21. Induction of smg p21/rap1A p21/krev-1 p21 gene expression during phorbol ester-induced differentiation of a human megakaryocytic leukemia cell line. Adachi, M., Ryo, R., Yoshida, A., Sugano, W., Yasunaga, M., Saigo, K., Yamaguchi, N., Sato, T., Sano, K., Kaibuchi, K. Oncogene (1992) [Pubmed]
  22. A novel type of MLL/AF10 fusion transcript in a child with acute megakaryocytic leukemia (AML-M7). Borkhardt, A., Haas, O.A., Strobl, W., Repp, R., Mann, G., Gadner, H., Lampert, F. Leukemia (1995) [Pubmed]
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