Gene Review:
Rora - RAR-related orphan receptor alpha
Mus musculus
Synonyms:
9530021D13Rik, Nr1f1, Nuclear receptor ROR-alpha, Nuclear receptor RZR-alpha, Nuclear receptor subfamily 1 group F member 1, ...
- RORalpha regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells: caveolin-3 and CPT-1 are direct targets of ROR. Lau, P., Nixon, S.J., Parton, R.G., Muscat, G.E. J. Biol. Chem. (2004)
- Retinoic acid receptor-related orphan receptor (ROR) alpha4 is the predominant isoform of the nuclear receptor RORalpha in the liver and is up-regulated by hypoxia in HepG2 human hepatoma cells. Chauvet, C., Bois-Joyeux, B., Danan, J.L. Biochem. J. (2002)
- Cellular distribution of gangliosides in the developing mouse cerebellum: analysis using the staggerer mutant. Seyfried, T.N., Bernard, D.J., Yu, R.K. J. Neurochem. (1984)
- Glutamate dehydrogenase in cerebellar mutant mice: gene localization and enzyme activity in different tissues. Miret-Duvaux, O., Frederic, F., Simon, D., Guenet, J.L., Hanauer, A., Delhaye-Bouchaud, N., Mariani, J. J. Neurochem. (1990)
- Enhanced susceptibility of staggerer (RORalphasg/sg) mice to lipopolysaccharide-induced lung inflammation. Stapleton, C.M., Jaradat, M., Dixon, D., Kang, H.S., Kim, S.C., Liao, G., Carey, M.A., Cristiano, J., Moorman, M.P., Jetten, A.M. Am. J. Physiol. Lung Cell Mol. Physiol. (2005)
- A functional genomics strategy reveals Rora as a component of the mammalian circadian clock. Sato, T.K., Panda, S., Miraglia, L.J., Reyes, T.M., Rudic, R.D., McNamara, P., Naik, K.A., FitzGerald, G.A., Kay, S.A., Hogenesch, J.B. Neuron (2004)
- A comparative study of Purkinje cells in two RORalpha gene mutant mice: staggerer and RORalpha(-/-). Doulazmi, M., Frédéric, F., Capone, F., Becker-André, M., Delhaye-Bouchaud, N., Mariani, J. Brain Res. Dev. Brain Res. (2001)
- Restoration of staggerer mouse maternal behavior following long-term breeding selection. Boufares, S., Guastavino, J.M., Larsson, K. Physiol. Behav. (1993)
- Effects of the rearing temperature on the temporal feeding pattern of the staggerer mutant mouse. Guastavino, J.M., Bertin, R., Portet, R. Physiol. Behav. (1991)
- Exploration and spatial learning in staggerer mutant mice. Lalonde, R. J. Neurogenet. (1987)
- Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of ROR2. Afzal, A.R., Rajab, A., Fenske, C.D., Oldridge, M., Elanko, N., Ternes-Pereira, E., Tüysüz, B., Murday, V.A., Patton, M.A., Wilkie, A.O., Jeffery, S. Nat. Genet. (2000)
- Disruption of the nuclear hormone receptor RORalpha in staggerer mice. Hamilton, B.A., Frankel, W.N., Kerrebrock, A.W., Hawkins, T.L., FitzHugh, W., Kusumi, K., Russell, L.B., Mueller, K.L., van Berkel, V., Birren, B.W., Kruglyak, L., Lander, E.S. Nature (1996)
- Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors. Giguère, V., Tini, M., Flock, G., Ong, E., Evans, R.M., Otulakowski, G. Genes Dev. (1994)
- Melatonin and RZR/ROR receptor ligand CGP 52608 induce apoptosis in the murine colonic cancer. Winczyk, K., Pawlikowski, M., Karasek, M. J. Pineal Res. (2001)
- The orphan nuclear receptor ROR alpha (RORA) maps to a conserved region of homology on human chromosome 15q21-q22 and mouse chromosome 9. Giguère, V., Beatty, B., Squire, J., Copeland, N.G., Jenkins, N.A. Genomics (1995)
- Embryonic to adult conversion of neural cell adhesion molecules in normal and staggerer mice. Edelman, G.M., Chuong, C.M. Proc. Natl. Acad. Sci. U.S.A. (1982)
- Regional variation in expression of calbindin and inositol 1,4,5-trisphosphate receptor type 1 mRNAs in the cerebellum of the staggerer mutant mouse. Nakagawa, S., Watanabe, M., Inoue, Y. Eur. J. Neurosci. (1996)
- Presence of calbindin D28K and GAD67 mRNAs in both orthotopic and ectopic Purkinje cells of staggerer mice suggests that staggerer acts after the onset of cytodifferentiation. Frantz, G.D., Wuenschell, C.W., Messer, A., Tobin, A.J. J. Neurosci. Res. (1996)
- Expression pattern and neurotrophic role of the c-fms proto-oncogene M-CSF receptor in rodent Purkinje cells. Murase, S., Hayashi, Y. J. Neurosci. (1998)
- The structural integrity of ROR alpha isoforms is mutated in staggerer mice: cerebellar coexpression of ROR alpha1 and ROR alpha4. Matysiak-Scholze, U., Nehls, M. Genomics (1997)
- Cerebellar benzodiazepine receptors: cellular localization and consequences of neurological mutations in mice. Rotter, A., Frostholm, A. Brain Res. (1988)
- ROR alpha gene expression in the perinatal rat cerebellum: ontogeny and thyroid hormone regulation. Koibuchi, N., Chin, W.W. Endocrinology (1998)
- Transcriptional regulation of a Purkinje cell-specific gene through a functional interaction between ROR alpha and RAR. Matsui, T. Genes Cells (1997)
- Developmental expression and intracellular location of P400 protein characteristic of Purkinje cells in the mouse cerebellum. Maeda, N., Niinobe, M., Inoue, Y., Mikoshiba, K. Dev. Biol. (1989)
- Differential IL-6 mRNA expression by stimulated peripheral macrophages of Staggerer and Lurcher cerebellar mutant mice. Kopmels, B., Mariani, J., Taupin, V., Delhaye-Bouchaud, N., Wollman, E.E. Eur. Cytokine Netw. (1991)
- Social isolation induces preference for odours of oestrous females in sexually naive male staggerer mutant mice. Féron, C., Baudoin, C. Chem. Senses (1998)
- Chromosomal location of the gene encoding the neural cell adhesion molecule (N-CAM) in the mouse. D'Eustachio, P., Owens, G.C., Edelman, G.M., Cunningham, B.A. Proc. Natl. Acad. Sci. U.S.A. (1985)
- Dependence of parvalbumin expression on Purkinje cell input in the deep cerebellar nuclei. Bäurle, J., Hoshi, M., Grüsser-Cornehls, U. J. Comp. Neurol. (1998)
- Parallin, a cerebellar granule cell protein the expression of which is developmentally regulated by Purkinje cells: evidence from mutant mice. Smith, A.M., Mullen, R.J. Brain Res. Dev. Brain Res. (1997)
- Interleukin-1 hyperproduction by in vitro activated peripheral macrophages from cerebellar mutant mice. Kopmels, B., Wollman, E.E., Guastavino, J.M., Delhaye-Bouchaud, N., Fradelizi, D., Mariani, J. J. Neurochem. (1990)
- Cytological compartmentalization in the staggerer cerebellum, as revealed by calbindin immunohistochemistry for Purkinje cells. Nakagawa, S., Watanabe, M., Isobe, T., Kondo, H., Inoue, Y. J. Comp. Neurol. (1998)
- Intranuclear relocation of the Plc beta3 sequence in cerebellar purkinje neurons: temporal association with de novo expression during development. Martou, G., Park, P.C., De Boni, U. Chromosoma (2002)
- Severe atherosclerosis and hypoalphalipoproteinemia in the staggerer mouse, a mutant of the nuclear receptor RORalpha. Mamontova, A., Séguret-Macé, S., Esposito, B., Chaniale, C., Bouly, M., Delhaye-Bouchaud, N., Luc, G., Staels, B., Duverger, N., Mariani, J., Tedgui, A. Circulation (1998)