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Gene Review

Nme1  -  NME/NM23 nucleoside diphosphate kinase 1

Mus musculus

Synonyms: AL024257, Metastasis inhibition factor NM23, NDK A, NDP kinase A, NDPK-A, ...
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Disease relevance of Nme1


High impact information on Nme1

  • We also find that the human Nm23 protein has sequence homology over the entire translated region with a recently described developmentally regulated protein in Drosophila, encoded by the abnormal wing discs (awd) gene [1].
  • We find that NDPK-A S122 and S144 are phosphorylated by AMPK alpha1 and that the phosphorylation status of S122, but not S144, determines whether substrate channeling can occur [5].
  • Nm23/nucleoside diphosphate kinase: toward a structural and biochemical understanding of its biological functions [6].
  • Translational control of putative protooncogene Nm23-M2 by cytokines via phosphoinositide 3-kinase signaling [7].
  • The expression of Nm23 from a retroviral vector in the absence of its 5'-untranslated region caused constitutive polysome association of nm23-M2 [7].

Chemical compound and disease context of Nme1


Biological context of Nme1


Anatomical context of Nme1


Associations of Nme1 with chemical compounds

  • Intermolecular cross-linking between Cys109-Cys109, which is highly possible based on the X-ray crystal structure of NDPK-A, and oxidations of four methionine residues were identified in H(2)O(2)-treated NDPK [16].
  • A serine phosphorylation of Nm23, and not its nucleoside diphosphate kinase activity, correlates with suppression of tumor metastatic potential [8].
  • The entire nm23-M1 and -M2 gene-coding regions were translated as fusion proteins with a glutathione S-transferase [17].
  • Curcumin enhances the expression of antimetastatic proteins, tissue inhibitor metalloproteinase (TIMP)-2, nonmetastatic gene 23 (Nm23), and E-cadherin [18].

Other interactions of Nme1


Analytical, diagnostic and therapeutic context of Nme1


  1. Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development. Rosengard, A.M., Krutzsch, H.C., Shearn, A., Biggs, J.R., Barker, E., Margulies, I.M., King, C.R., Liotta, L.A., Steeg, P.S. Nature (1989) [Pubmed]
  2. Two isotypes of murine nm23/nucleoside diphosphate kinase, nm23-M1 and nm23-M2, are involved in metastatic suppression of a murine melanoma line. Baba, H., Urano, T., Okada, K., Furukawa, K., Nakayama, E., Tanaka, H., Iwasaki, K., Shiku, H. Cancer Res. (1995) [Pubmed]
  3. Nm23 and breast cancer metastasis. Steeg, P.S., de la Rosa, A., Flatow, U., MacDonald, N.J., Benedict, M., Leone, A. Breast Cancer Res. Treat. (1993) [Pubmed]
  4. Increased lung metastasis in transgenic NM23-Null/SV40 mice with hepatocellular carcinoma. Boissan, M., Wendum, D., Arnaud-Dabernat, S., Munier, A., Debray, M., Lascu, I., Daniel, J.Y., Lacombe, M.L. J. Natl. Cancer Inst. (2005) [Pubmed]
  5. Understanding the molecular basis of the interaction between NDPK-A and AMPK alpha 1. Crawford, R.M., Treharne, K.J., Arnaud-Dabernat, S., Daniel, J.Y., Foretz, M., Viollet, B., Mehta, A. Mol. Cell. Biol. (2006) [Pubmed]
  6. Nm23/nucleoside diphosphate kinase: toward a structural and biochemical understanding of its biological functions. de la Rosa, A., Williams, R.L., Steeg, P.S. Bioessays (1995) [Pubmed]
  7. Translational control of putative protooncogene Nm23-M2 by cytokines via phosphoinositide 3-kinase signaling. Joosten, M., Blázquez-Domingo, M., Lindeboom, F., Boulmé, F., Van Hoven-Beijen, A., Habermann, B., Löwenberg, B., Beug, H., Müllner, E.W., Delwel, R., Von Lindern, M. J. Biol. Chem. (2004) [Pubmed]
  8. A serine phosphorylation of Nm23, and not its nucleoside diphosphate kinase activity, correlates with suppression of tumor metastatic potential. MacDonald, N.J., De la Rosa, A., Benedict, M.A., Freije, J.M., Krutsch, H., Steeg, P.S. J. Biol. Chem. (1993) [Pubmed]
  9. Expression of nm23/nucleoside diphosphate kinase-A protein in endometrial carcinoma. Srivatsa, P.J., Cliby, W.A., Keeney, G.L., Suman, V.J., Harmsen, W.S., Ziesmer, S.C., Roche, P.C., Podratz, K.C. Gynecol. Oncol. (1997) [Pubmed]
  10. Nm23-M2/NDP kinase B induces endogenous c-myc and nm23-M1/NDP kinase A overexpression in BAF3 cells. Both NDP kinases protect the cells from oxidative stress-induced death. Arnaud-Dabernat, S., Masse, K., Smani, M., Peuchant, E., Landry, M., Bourbon, P.M., Le Floch, R., Daniel, J.Y., Larou, M. Exp. Cell Res. (2004) [Pubmed]
  11. Organization and expression of mouse nm23-M1 gene. Comparison with nm23-M2 expression. Dabernat, S., Larou, M., Massé, K., Dobremez, E., Landry, M., Mathieu, C., Daniel, J.Y. Gene (1999) [Pubmed]
  12. Cloning of a second nm23-M1 cDNA: expression in the central nervous system of adult mouse and comparison with nm23-M2 mRNA distribution. Dabernat, S., Larou, M., Massé, K., Hökfelt, T., Mayer, G., Daniel, J.Y., Landry, M. Brain Res. Mol. Brain Res. (1999) [Pubmed]
  13. The association of the Nm23-M1 protein and beta-tubulin correlates with cell differentiation. Lombardi, D., Sacchi, A., D'Agostino, G., Tibursi, G. Exp. Cell Res. (1995) [Pubmed]
  14. Expression patterns of nm23 genes during mouse organogenesis. Amrein, L., Barraud, P., Daniel, J.Y., Pérel, Y., Landry, M. Cell Tissue Res. (2005) [Pubmed]
  15. Embryonic expression of nm23 during mouse organogenesis. Lakso, M., Steeg, P.S., Westphal, H. Cell Growth Differ. (1992) [Pubmed]
  16. Oxidative modification of nucleoside diphosphate kinase and its identification by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Song, E.J., Kim, Y.S., Chung, J.Y., Kim, E., Chae, S.K., Lee, K.J. Biochemistry (2000) [Pubmed]
  17. Molecular cloning and functional expression of the second mouse nm23/NDP kinase gene, nm23-M2. Urano, T., Takamiya, K., Furukawa, K., Shiku, H. FEBS Lett. (1992) [Pubmed]
  18. Curcumin exhibits antimetastatic properties by modulating integrin receptors, collagenase activity, and expression of Nm23 and E-cadherin. Ray, S., Chattopadhyay, N., Mitra, A., Siddiqi, M., Chatterjee, A. J. Environ. Pathol. Toxicol. Oncol. (2003) [Pubmed]
  19. Differential expression of nm23 genes in adult mouse dorsal root ganglia. Barraud, P., Amrein, L., Dobremez, E., Dabernat, S., Masse, K., Larou, M., Daniel, J.Y., Landry, M. J. Comp. Neurol. (2002) [Pubmed]
  20. The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily. Paravicini, G., Steinmayr, M., André, E., Becker-André, M. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  21. Identification of novel mRNA transcripts of the nm23-M1 gene that are modulated during mouse embryo development and are differently expressed in adult murine tissues. Gervasi, F., Capozza, F., Bruno, T., Fanciulli, M., Lombardi, D. DNA Cell Biol. (1998) [Pubmed]
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