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Gene Review

Zfy2  -  zinc finger protein 2, Y linked

Mus musculus

Synonyms: Zfy-2, Zinc finger Y-chromosomal protein 2
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High impact information on Zfy2


Biological context of Zfy2


Anatomical context of Zfy2

  • In adults, the data suggest that Zfy-1 and Zfy-2 transcription is linked to spermatogenesis, that transcription increases with the initiation of meiosis, and that high levels of these mRNAs are found in postmeiotic round spermatid cells [3].

Associations of Zfy2 with chemical compounds


Enzymatic interactions of Zfy2

  • Sxrb, a derivative of Sxra, was previously thought to retain Zfy-1 but to be deleted for Zfy-2 [9].

Other interactions of Zfy2

  • Zfy-1 and Zfy-2 are candidate genes for Tdy, the testis-determining gene in mice [10].


  1. The sex-determining region of the mouse Y chromosome encodes a protein with a highly acidic domain and 13 zinc fingers. Mardon, G., Page, D.C. Cell (1989) [Pubmed]
  2. Duplication, deletion, and polymorphism in the sex-determining region of the mouse Y chromosome. Mardon, G., Mosher, R., Disteche, C.M., Nishioka, Y., McLaren, A., Page, D.C. Science (1989) [Pubmed]
  3. The two candidate testis-determining Y genes (Zfy-1 and Zfy-2) are differentially expressed in fetal and adult mouse tissues. Nagamine, C.M., Chan, K., Hake, L.E., Lau, Y.F. Genes Dev. (1990) [Pubmed]
  4. Mouse Zfx protein is similar to Zfy-2: each contains an acidic activating domain and 13 zinc fingers. Mardon, G., Luoh, S.W., Simpson, E.M., Gill, G., Brown, L.G., Page, D.C. Mol. Cell. Biol. (1990) [Pubmed]
  5. Intron/exon structure confirms that mouse Zfy1 and Zfy2 are members of the ZFY gene family. Mahaffey, C.L., Bayleran, J.K., Yeh, G.Y., Lee, T.C., Page, D.C., Simpson, E.M. Genomics (1997) [Pubmed]
  6. The case of the midwife scientist. Simpson, E. Int. J. Dev. Biol. (2001) [Pubmed]
  7. Discordant phylogeographic patterns between the Y chromosome and mitochondrial DNA in the house mouse: selection on the Y chromosome? Boissinot, S., Boursot, P. Genetics (1997) [Pubmed]
  8. Zfy2/1 fusion gene fails to replicate Zfy1 expression pattern in fetal gonads. Nagamine, C.M., Carlisle, C. Genomics (1997) [Pubmed]
  9. An interstitial deletion in mouse Y chromosomal DNA created a transcribed Zfy fusion gene. Simpson, E.M., Page, D.C. Genomics (1991) [Pubmed]
  10. Normal structure and expression of Zfy genes in XY female mice mutant in Tdy. Gubbay, J., Koopman, P., Collignon, J., Burgoyne, P., Lovell-Badge, R. Development (1990) [Pubmed]
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