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Gene Review

Zfx  -  zinc finger protein X-linked

Mus musculus

Synonyms: Zfx5, Zfx5,6, Zfx6, Zinc finger X-chromosomal protein
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Disease relevance of Zfx

  • We also show that the mouse androgen receptor locus (m-AR) believed to underlie the testicular feminization mutation (Tfm) shows complete linkage to Zfx [1].

High impact information on Zfx

  • A1s9X is similar to the Zfx gene in undergoing X-inactivation, yet having homologous sequences on the short arm of the Y chromosome, which are expressed in the testis [2].
  • We have devised a system to analyse whether specific genes on the mouse X chromosome are inactivated, and demonstrate that both Zfx and Rps4X undergo normal X-inactivation in mice [3].
  • Zfa is an expressed retroposon derived from an alternative transcript of the Zfx gene [4].
  • Using this allelic variation, we assessed expression of the two Zfx genes in females carrying the T(X;16)16H translocation (from laboratory strain of mouse [corrected]) and an intact X chromosome (from M. spretus) [5].
  • Such females exhibit Zfx transcription from the active laboratory strain of mouse [corrected] chromosome but not from the inactive M. spretus chromosome [5].

Biological context of Zfx


Anatomical context of Zfx

  • Zfx mutation results in small animal size and reduced germ cell number in male and female mice [9].

Other interactions of Zfx

  • An analysis of cDNA clones demonstrated that Zfx encodes a 799-amino-acid protein that is 70% identical to the mouse Zfy-1 and Zfy-2 proteins [6].
  • We show here that Zfa has arisen recently by retroposition of one of at least three alternatively spliced mRNAs transcribed from the Zfx gene [4].
  • Pulsed-field mapping of a number of DNA markers in the Pola-Zfx region of the mouse X chromosome has established a genomic restriction map extending over 1.4 Mb [10].
  • Physical mapping of the transgene by FISH localized a single insertion site to the interval between Dmd and Zfx on the X Chr [11].
  • The presence or absence of a region of the Sry (sex-determining region Y) gene determines sex, and amplification of the Zfy (male) or Zfx (female) genes acts as a positive control for PCR [12].

Analytical, diagnostic and therapeutic context of Zfx


  1. Localization of murine X and autosomal sequences homologous to the human Y located testis-determining region. Mitchell, M., Simon, D., Affara, N., Ferguson-Smith, M., Avner, P., Bishop, C. Genetics (1989) [Pubmed]
  2. A candidate spermatogenesis gene on the mouse Y chromosome is homologous to ubiquitin-activating enzyme E1. Kay, G.F., Ashworth, A., Penny, G.D., Dunlop, M., Swift, S., Brockdorff, N., Rastan, S. Nature (1991) [Pubmed]
  3. X-chromosome inactivation may explain the difference in viability of XO humans and mice. Ashworth, A., Rastan, S., Lovell-Badge, R., Kay, G. Nature (1991) [Pubmed]
  4. Zfa is an expressed retroposon derived from an alternative transcript of the Zfx gene. Ashworth, A., Skene, B., Swift, S., Lovell-Badge, R. EMBO J. (1990) [Pubmed]
  5. Inactivation of the Zfx gene on the mouse X chromosome. Adler, D.A., Bressler, S.L., Chapman, V.M., Page, D.C., Disteche, C.M. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  6. Mouse Zfx protein is similar to Zfy-2: each contains an acidic activating domain and 13 zinc fingers. Mardon, G., Luoh, S.W., Simpson, E.M., Gill, G., Brown, L.G., Page, D.C. Mol. Cell. Biol. (1990) [Pubmed]
  7. Maintenance of X inactivation of the Rps4, Zfx, and Ube1 genes in a mouse in vitro system. Bressler, S.L., Lee, K.H., Adler, D.A., Chapman, V.M., Disteche, C.M. Somat. Cell Mol. Genet. (1993) [Pubmed]
  8. The structure of the Zfx gene on the mouse X chromosome. Luoh, S.W., Page, D.C. Genomics (1994) [Pubmed]
  9. Zfx mutation results in small animal size and reduced germ cell number in male and female mice. Luoh, S.W., Bain, P.A., Polakiewicz, R.D., Goodheart, M.L., Gardner, H., Jaenisch, R., Page, D.C. Development (1997) [Pubmed]
  10. YAC clone contigs surrounding the Zfx and Pola loci on the mouse X chromosome. Hamvas, R.M., Larin, Z., Brockdorff, N., Rastan, S., Lehrach, H., Chartier, F.L., Brown, S.D. Genomics (1993) [Pubmed]
  11. exma: an X-linked insertional mutation that disrupts forebrain and eye development. Cunningham, D., Xiao, Q., Chatterjee, A., Sulik, K., Juriloff, D., Elder, F., Harrison, W., Schuster, G., Overbeek, P.A., Herman, G.E. Mamm. Genome (2002) [Pubmed]
  12. Sex identification in mammals with polymerase chain reaction and its use to examine sex effects on diameter of day-10 or -11 pig embryos. Pomp, D., Good, B.A., Geisert, R.D., Corbin, C.J., Conley, A.J. J. Anim. Sci. (1995) [Pubmed]
  13. Gene expression, X-inactivation, and methylation during spermatogenesis: the case of Zfa, Zfx, and Zfy in mice. Erickson, R.P., Zwingman, T., Ao, A. Mol. Reprod. Dev. (1993) [Pubmed]
  14. Unusual distribution of Zfy and Zfx sequences on the sex chromosomes of the wood lemming, a species exhibiting XY sex reversal. Lau, Y.F., Yang-Feng, T.L., Elder, B., Fredga, K., Wiberg, U.H. Cytogenet. Cell Genet. (1992) [Pubmed]
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