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Gene Review

Tp(Y)1Ct  -  transposition, Chr Y, Cattanach 1

Mus musculus

Synonyms: Sxr, Tp1Ct
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Disease relevance of Tp(Y)1Ct


High impact information on Tp(Y)1Ct

  • The conserved nucleotide sequences of Bkm, which define Sxr in the mouse, are transcribed [2].
  • Satellite DNA (Bkm) from the W sex-determining chromosome of snakes, which is related to sequences on the mouse Y chromosome, has been used to analyze the DNA and chromosomes of sex-reversed (Sxr) XXSxr male mice [3].
  • Meitoic crossing-over between the X and Y chromosomes of male mice carrying the sex-reversing (Sxr) factor [4].
  • Zfy-1 alone may suffice to determine maleness; Zfy-2 is dispensable, as it was deleted in an Sxr variant that retains sex-determining function but has lost other genes [5].
  • The original sex-reversed females appeared among the offspring of XY males that carried the Yp duplication Sxr on their X chromosome [6].

Biological context of Tp(Y)1Ct

  • A structural analysis of the Sxr region of the mouse Y chromosome [7].
  • T-cell and antibody typing of a mouse population segregating for Sxr and H-2 haplotype [8].
  • DNA fingerprinting revealed that the banding pattern characteristic of Sxr' had been replaced by the pattern associated with the native testis-determining region of the normal Y chromosome of that stock, presumably by pairing and crossing-over between the two testis-determining regions of the father's Y Sxr' chromosome [9].
  • Also, we show that intrachromosomal recombination between the Y short arm and Sxr' can sometimes occur during male meiosis, restoring the deleted DNA sequences and resulting in an H-Y+ mouse (male 719 in this paper) [10].
  • Spy is present in the Y-derived Sxr fragment so XOSxr germ cells enter meiosis normally [11].

Anatomical context of Tp(Y)1Ct


Associations of Tp(Y)1Ct with chemical compounds


Enzymatic interactions of Tp(Y)1Ct

  • Hya and Spy map to DNA deleted from the Sxr region in the deletion variant Sxrb (the delta Sxrb DNA) [7].

Other interactions of Tp(Y)1Ct

  • Our data is in contrast to a recent report of a recombination frequency separating Sts and Sxr of as high as 6.2-9.8% [20].
  • Moreover, the mutation is complemented by Sxr', the minimum portion of the mouse Y known to carry Tdy [21].

Analytical, diagnostic and therapeutic context of Tp(Y)1Ct

  • The possibility that hormonal differences could instead be responsible for the lower activity in females was ruled out by the findings that (a) castration of males did not reduce their STS levels and (b) sex-reversed males, X/X Sxr, had STS levels typical of females [22].
  • We now demonstrate the presence of chromosome Y-related DNA sequences on proximal chromosome 17 in Sex-reversed (Sxr) and normal mice using in situ hybridization of mitotic chromosomes with 3H-labelled pCS316 (ref. 4), a probe that shows major hybridization to the proximal portion of the mouse chromosome Y [23].
  • Total mouse Y-chromosome libraries were constructed from flow-sorted material and a Sxr regional library after specific microdissection and cloning [24].
  • One clone from each family was chosen for detailed analysis by Southern blot hybridization, polymerase chain reaction (PCR) on normal and aberrant genomes (Sxr), and fluorescence in situ hybridization [25].
  • Previous work has established that whereas X/X mice carrying the sex-reversing chromosomal fragment Sxr are positive for the male-specific transplantation antigen, H-Y, X/X mice carrying the variant Sxr', although they too develop as phenotypic males, are H-Y negative [26].


  1. Cell death in the mosaic epididymis of sex reversed mice, heterozygous for testicular feminization. Drews, U., Dieterich, H.J. Anat. Embryol. (1978) [Pubmed]
  2. The conserved nucleotide sequences of Bkm, which define Sxr in the mouse, are transcribed. Singh, L., Phillips, C., Jones, K.W. Cell (1984) [Pubmed]
  3. Sex reversal in the mouse (Mus musculus) is caused by a recurrent nonreciprocal crossover involving the x and an aberrant y chromosome. Singh, L., Jones, K.W. Cell (1982) [Pubmed]
  4. Meitoic crossing-over between the X and Y chromosomes of male mice carrying the sex-reversing (Sxr) factor. Evans, E.P., Burtenshaw, M.D., Cattanach, B.M. Nature (1982) [Pubmed]
  5. Duplication, deletion, and polymorphism in the sex-determining region of the mouse Y chromosome. Mardon, G., Mosher, R., Disteche, C.M., Nishioka, Y., McLaren, A., Page, D.C. Science (1989) [Pubmed]
  6. Y chromosome short arm-Sxr recombination in XSxr/Y males causes deletion of Rbm and XY female sex reversal. Laval, S.H., Glenister, P.H., Rasberry, C., Thornton, C.E., Mahadevaiah, S.K., Cooke, H.J., Burgoyne, P.S., Cattanach, B.M. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  7. A structural analysis of the Sxr region of the mouse Y chromosome. Mitchell, M.J., Bishop, C.E. Genomics (1992) [Pubmed]
  8. T-cell and antibody typing of a mouse population segregating for Sxr and H-2 haplotype. Simpson, E., Chandler, P., Tomonari, K., Loveland, B., McLaren, A. Cell. Immunol. (1986) [Pubmed]
  9. Location of the genes controlling H-Y antigen expression and testis determination on the mouse Y chromosome. McLaren, A., Simpson, E., Epplen, J.T., Studer, R., Koopman, P., Evans, E.P., Burgoyne, P.S. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  10. Molecular and cytogenetic evidence for the location of Tdy and Hya on the mouse Y chromosome short arm. Roberts, C., Weith, A., Passage, E., Michot, J.L., Mattei, M.G., Bishop, C.E. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  11. The role of the mammalian Y chromosome in spermatogenesis. Burgoyne, P.S. Development (1987) [Pubmed]
  12. Analysis of male sterile mutations in the mouse using haploid stage expressed cDNA probes. Dudley, K., Potter, J., Lyon, M.F., Willison, K.R. Nucleic Acids Res. (1984) [Pubmed]
  13. Sex chromosome pairing patterns in male mice of novel Sxr genotypes. Tease, C., Cattanach, B.M. Chromosoma (1989) [Pubmed]
  14. Evidence for a defective seminiferous tubule barrier in testes of Tfm and Sxr mice. Fritz, I.B., Lyon, M.F., Setchell, B.P. J. Reprod. Fertil. (1983) [Pubmed]
  15. Functional capacity of sex-reversed (XX, Sxr/+) mouse germ cells as shown by progeny derived from XX, Sxr/+ oocytes of a female chimera. Bradbury, M.W. J. Exp. Zool. (1983) [Pubmed]
  16. Ultrastructural abnormalities of epididymal tissues in XXSxr pseudomale (sex-reversed) mice. Wilkinson, L., Sweeny, P.R., Blecher, S.R. Arch. Androl. (1988) [Pubmed]
  17. Leydig cell function in the absence of an intact Y chromosome. Chubb, C., Nolan, C. Biol. Reprod. (1984) [Pubmed]
  18. Spermatogenesis and sperm-specific phosphoglycerate kinase B and lactate dehydrogenase C4 isoenzymes in sex-reversed mice. Rudolph, N.S., Shovers, J.B., VandeBerg, J.L. J. Reprod. Fertil. (1982) [Pubmed]
  19. Testicular steroidogenesis in X/X sex-reversed mice. O'Shaughnessy, P.J., Abbott, D.H., Leigh, A.J., Cattanach, B.M. Int. J. Androl. (1991) [Pubmed]
  20. Linkage of the murine steroid sulfatase locus, Sts, to sex reversed, Sxr: a genetic and molecular analysis. Nagamine, C.M., Michot, J.L., Roberts, C., Guénet, J.L., Bishop, C.E. Nucleic Acids Res. (1987) [Pubmed]
  21. XY female mice resulting from a heritable mutation in the primary testis-determining gene, Tdy. Lovell-Badge, R., Robertson, E. Development (1990) [Pubmed]
  22. X-inactivation of the Sts locus in the mouse: an anomaly of the dosage compensation mechanism. Jones, J., Peters, J., Rasberry, C., Cattanach, B.M. Genet. Res. (1989) [Pubmed]
  23. Regional localization of sex-specific Bkm-related sequences on proximal chromosome 17 of mice. Kiel-Metzger, K., Erickson, R.P. Nature (1984) [Pubmed]
  24. The use of specific DNA probes to analyse the Sxr mutation in the mouse. Bishop, C.E., Roberts, C., Michot, J.L., Nagamine, C., Winking, H., Guénet, J.L., Weith, A. Development (1987) [Pubmed]
  25. Mouse Y-specific repeats isolated by whole chromosome representational difference analysis. Navin, A., Prekeris, R., Lisitsyn, N.A., Sonti, M.M., Grieco, D.A., Narayanswami, S., Lander, E.S., Simpson, E.M. Genomics (1996) [Pubmed]
  26. Absence of any male-specific antigen recognized by T lymphocytes in X/XSxr' male mice. McLaren, A., Hunt, R., Simpson, E. Immunology (1988) [Pubmed]
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