The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

CAMTA1  -  calmodulin binding transcription activator 1

Homo sapiens

Synonyms: Calmodulin-binding transcription activator 1, KIAA0833, MSTP023
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CAMTA1

  • Mutation analysis of the exons encoding conserved regions of CAMTA1 showed no somatic mutations in 10 gliomas, including 6 cases with and 4 cases without 1p LOH [1].
  • All informative tumors in the oligodendroglial group and 2 of 3 informative astrocytomas showed LOH at 1p36.23, with a 150-kb MDR located between D1S2694 and D1S2666, entirely within the CAMTA1 transcription factor gene [1].
  • CONCLUSIONS: Our data confirm the strong association of combined 1p/19q loss with classic oligodendroglioma histology and identify a very small segment of 1p36 located within CAMTA1 that was deleted in all oligodendroglial tumors with 1p LOH [1].
  • This result suggested that CAMTA1 could associate with the differentiation of neuroblastoma cells [2].

High impact information on CAMTA1

  • Our data suggest that calmodulin/CAMTA/Fbxl4 may mediate a long-term feedback regulation of the activity of Ca(2+)-stimulating GPCRs, which could prevent cell damage due to extra Ca(2+) influx [3].
  • The Fly CAMTA Transcription Factor Potentiates Deactivation of Rhodopsin, a G Protein-Coupled Light Receptor [3].
  • RESULTS: The commonly deleted region spans 261 kb and encompasses two genes, FLJ10737 and CAMTA1 [4].
  • In contrast, low CAMTA1 expression characterized tumors with 1p deletion, MYCN amplification, and advanced tumor stages 3 and 4 [4].
  • Reduced expression of CAMTA1 correlates with adverse outcome in neuroblastoma patients [4].

Psychiatry related information on CAMTA1

  • Our validated genomic and functional biological findings described herein suggest a role for CAMTA1 in human episodic memory [5].

Biological context of CAMTA1


Anatomical context of CAMTA1


Other interactions of CAMTA1


Analytical, diagnostic and therapeutic context of CAMTA1


  1. Allelic losses at 1p36 and 19q13 in gliomas: correlation with histologic classification, definition of a 150-kb minimal deleted region on 1p36, and evaluation of CAMTA1 as a candidate tumor suppressor gene. Barbashina, V., Salazar, P., Holland, E.C., Rosenblum, M.K., Ladanyi, M. Clin. Cancer Res. (2005) [Pubmed]
  2. Cell cycle-dependent transcriptional regulation of calmodulin-binding transcription activator 1 in neuroblastoma cells. Nakatani, K., Nishioka, J., Itakura, T., Nakanishi, Y., Horinouchi, J., Abe, Y., Wada, H., Nobori, T. Int. J. Oncol. (2004) [Pubmed]
  3. The Fly CAMTA Transcription Factor Potentiates Deactivation of Rhodopsin, a G Protein-Coupled Light Receptor. Han, J., Gong, P., Reddig, K., Mitra, M., Guo, P., Li, H.S. Cell (2006) [Pubmed]
  4. Reduced expression of CAMTA1 correlates with adverse outcome in neuroblastoma patients. Henrich, K.O., Fischer, M., Mertens, D., Benner, A., Wiedemeyer, R., Brors, B., Oberthuer, A., Berthold, F., Wei, J.S., Khan, J., Schwab, M., Westermann, F. Clin. Cancer Res. (2006) [Pubmed]
  5. Calmodulin-binding transcription activator 1 (CAMTA1) alleles predispose human episodic memory performance. Huentelman, M.J., Papassotiropoulos, A., Craig, D.W., Hoerndli, F.J., Pearson, J.V., Huynh, K.D., Corneveaux, J., Hänggi, J., Mondadori, C.R., Buchmann, A., Reiman, E.M., Henke, K., de Quervain, D.J., Stephan, D.A. Hum. Mol. Genet. (2007) [Pubmed]
  6. Identification and characterization of FLJ10737 and CAMTA1 genes on the commonly deleted region of neuroblastoma at human chromosome 1p36.31-p36.23. Katoh, M., Katoh, M. Int. J. Oncol. (2003) [Pubmed]
  7. Allelic variants of CAMTA1 and FLJ10737 within a commonly deleted region at 1p36 in neuroblastoma. Henrich, K.O., Claas, A., Praml, C., Benner, A., Mollenhauer, J., Poustka, A., Schwab, M., Westermann, F. Eur. J. Cancer (2007) [Pubmed]
WikiGenes - Universities