Disease relevance of PES1

• During PES-1, a sustained ventricular arrhythmia was inducible in 18 of 34 patients (53%), 8 in the metoprolol and 10 in the sotalol arm.(ABSTRACT TRUNCATED AT 250 WORDS)[1]

High impact information on PES1

• These data show that coordinated action of Pes1 and Bop1 is necessary for the biogenesis of 60S ribosomal subunits [2].
• Six Pes1 mutants selected by their ability to reversibly arrest the cell cycle also impair maturation of the 28S and 5.8S rRNAs in mouse cells [2].
• Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation [3].
• Therefore, the promoter activities of the human genes for PES-1 and -2 in bovine arterial endothelial cells were examined [4].
• The 5'-flanking region of the human PES-2 gene (nucleotides -327 to +59) showed promoter activity inducible by LPS and TPA using transient transfection analysis, whereas that of the PES-1 gene (nucleotides -1010 to +69) showed constitutive promoter activity [4].

Chemical compound and disease context of PES1

• After undergoing baseline programmed electrical stimulation (PES-1) to assess arrhythmia inducibility, the patients were randomly assigned to a (double-blind) treatment of either metoprolol (16 patients) or sotalol (18 patients) [1].

Associations of PES1 with chemical compounds

• Indirect immunofluorescence, cell fractionation, and sucrose gradient centrifugation experiments indicate that transport of Bop1 from the cytoplasm to the nucleolus is Pes1 dependent, while Pes1 can migrate to the nucleolus and bind to preribosomal particles independently of Bop1 [5].

Biological context of PES1

• Pes1 mutants M1 and M5, with N- and C-terminal truncations, respectively, displayed a dominant-negative phenotype [6].
• The delta pes1 mutant also showed significantly reduced virulence in the Galleria mellonella model system (P < 0.001) and increased sensitivity to oxidative stress (P = 0.002) in culture and during neutrophil-mediated phagocytosis [7].

Anatomical context of PES1

• Esophageal pressure was measured through two water-filled catheters, one placed just above the cardia (Pes1) and the other at the level of the carina (Pes2) [8].

Analytical, diagnostic and therapeutic context of PES1

• The Pes1 protein (expected molecular mass 698 kDa) was partially purified and identified by immunoreactivity, peptide mass fingerprinting (36% sequence coverage) and MALDI LIFT-TOF/TOF MS (four internal peptides sequenced) [7].
• A pes1 disruption mutant (delta pes1) of Aspergillus fumigatus strain 293.1 was generated and confirmed by Southern and western analysis, in addition to RT-PCR [7].

References