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Gene Review

MZF1  -  myeloid zinc finger 1

Homo sapiens

Synonyms: MZF, MZF-1, MZF1B, Myeloid zinc finger 1, ZFP98, ...
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Disease relevance of MZF1


High impact information on MZF1


Biological context of MZF1


Anatomical context of MZF1

  • These results indicate that Sp1/Sp3 and MZF1 are important transcription factors regulating N-cadherin promoter activity and expression in osteoblasts [6].
  • These results indicate that Sp1 and MZF1 are involved in the transcriptional regulation of the hST6GalNAc IV gene in Jurkat T cells [10].
  • Human Rex-1 (hRex-1) (also referred to as zinc-finger protein-42, Zfp42) encodes a zinc finger protein expression of which is believed to be characteristic of pluripotent stem cells [11].

Associations of MZF1 with chemical compounds

  • Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations [7].
  • A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells [12].
  • PKCalpha expression regulated by Elk-1 and MZF-1 in human HCC cells [13].
  • Glutathione-S-transferase pull-down assays showed that the MZF1 SCAN domain self-associates, and a K(d) value of 600 nM was measured by intrinsic tryptophan fluorescence polarization [14].

Physical interactions of MZF1

  • The C-subunit of NFY was demonstrated to form a ternary complex with MZF-1/FHL3 and interact with a beta-chain gene region including the element in the fourth intron [5].

Regulatory relationships of MZF1

  • We also found that GM-CSF induced expression of MZF-1 and nuclear translocation of FHL3 [5].
  • Overexpression of FHL3 in KU812 cells suppressed the beta-chain promoter activity through the element in the fourth intron in an MZF-1-dependent manner [15].

Other interactions of MZF1

  • Collectively, these results indicated that HDACs, which were recruited to the beta-chain gene through the element in the fourth intron by MZF-1/FHL3/NFY, repressed beta-chain gene transcription by deacetylation of histones in the presence of GM-CSF [5].
  • RT-PCR analysis showed that human osteoblastic cells express MZF1 and that Sp1/MZF1 overexpression increased N-cadherin expression [6].
  • Co-immunoprecipitation assays demonstrate that the SCAN box domain of MZF1B is necessary for association with RAZ1 [7].

Analytical, diagnostic and therapeutic context of MZF1

  • However, at least three transcripts of approximately 3, 7.5, and 9kb are detected by MZF1-specific probes in northern blot analysis and the identity of the transcripts has not been addressed [9].
  • Further analysis by electrophoretic mobility shift assays using specific competitors and antibody revealed that Sp1 and MZF1 nuclear proteins interacted with these elements [10].
  • Site-directed mutagenesis and transient transfection assays demonstrated that Sp1 and MZF1 elements in this region were required for the promoter activity [10].
  • Furthermore, results from pull-down assays and gel-filtration chromatography employing nuclear extracts indicated that MZF-1 and FHL3 formed a complex of high molecular mass with some additional proteins in the nucleus [15].
  • Southwestern blots and UV cross-linking experiments identified myeloid zinc finger-1 (MZF-1) as a candidate transcription factor among proteins binding to the -250FP1 and FP2 sequences [16].


  1. The myeloid zinc finger gene (MZF-1) delays retinoic acid-induced apoptosis and differentiation in myeloid leukemia cells. Robertson, K.A., Hill, D.P., Kelley, M.R., Tritt, R., Crum, B., Van Epps, S., Srour, E., Rice, S., Hromas, R. Leukemia (1998) [Pubmed]
  2. Antisense oligonucleotides from the stage-specific myeloid zinc finger gene MZF-1 inhibit granulopoiesis in vitro. Bavisotto, L., Kaushansky, K., Lin, N., Hromas, R. J. Exp. Med. (1991) [Pubmed]
  3. The myeloid zinc finger gene, MZF-1, regulates the CD34 promoter in vitro. Morris, J.F., Rauscher, F.J., Davis, B., Klemsz, M., Xu, D., Tenen, D., Hromas, R. Blood (1995) [Pubmed]
  4. Overexpression of the zinc finger protein MZF1 inhibits hematopoietic development from embryonic stem cells: correlation with negative regulation of CD34 and c-myb promoter activity. Perrotti, D., Melotti, P., Skorski, T., Casella, I., Peschle, C., Calabretta, B. Mol. Cell. Biol. (1995) [Pubmed]
  5. Molecular Mechanisms for Transcriptional Regulation of Human High-Affinity IgE Receptor beta-Chain Gene Induced by GM-CSF. Takahashi, K., Hayashi, N., Kaminogawa, S., Ra, C. J. Immunol. (2006) [Pubmed]
  6. Sp1/Sp3 and the myeloid zinc finger gene MZF1 regulate the human N-cadherin promoter in osteoblasts. Le Mée, S., Fromigué, O., Marie, P.J. Exp. Cell Res. (2005) [Pubmed]
  7. Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations. Sander, T.L., Haas, A.L., Peterson, M.J., Morris, J.F. J. Biol. Chem. (2000) [Pubmed]
  8. LDOC1, a novel MZF-1-interacting protein, induces apoptosis. Inoue, M., Takahashi, K., Niide, O., Shibata, M., Fukuzawa, M., Ra, C. FEBS Lett. (2005) [Pubmed]
  9. Human myeloid zinc finger gene MZF produces multiple transcripts and encodes a SCAN box protein. Peterson, M.J., Morris, J.F. Gene (2000) [Pubmed]
  10. Regulatory elements involved in transcription of the human NeuAcalpha2,3Galbeta1,3GalNAcalpha2,6-sialyltransferase (hST6GalNAc IV) gene. Kang, N.Y., Park, Y.D., Choi, H.J., Kim, K.S., Lee, Y.C., Kim, C.H. Mol. Cells (2004) [Pubmed]
  11. The putative human stem cell marker, Rex-1 (Zfp42): Structural classification and expression in normal human epithelial and carcinoma cell cultures. Mongan, N.P., Martin, K.M., Gudas, L.J. Mol. Carcinog. (2006) [Pubmed]
  12. A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells. Hromas, R., Collins, S.J., Hickstein, D., Raskind, W., Deaven, L.L., O'Hara, P., Hagen, F.S., Kaushansky, K. J. Biol. Chem. (1991) [Pubmed]
  13. PKCalpha expression regulated by Elk-1 and MZF-1 in human HCC cells. Hsieh, Y.H., Wu, T.T., Tsai, J.H., Huang, C.Y., Hsieh, Y.S., Liu, J.Y. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  14. Structure of the SCAN Domain from the Tumor Suppressor protein MZF1. Peterson, F.C., Hayes, P.L., Waltner, J.K., Heisner, A.K., Jensen, D.R., Sander, T.L., Volkman, B.F. J. Mol. Biol. (2006) [Pubmed]
  15. FHL3 negatively regulates human high-affinity IgE receptor beta-chain gene expression by acting as a transcriptional co-repressor of MZF-1. Takahashi, K., Matsumoto, C., Ra, C. Biochem. J. (2005) [Pubmed]
  16. MZF-1 and DbpA interact with DNase I hypersensitive sites that correlate with expression of the human MUC1 mucin gene. Shiraga, T., Winpenny, J.P., Carter, E.J., McCarthy, V.A., Hollingsworth, M.A., Harris, A. Exp. Cell Res. (2005) [Pubmed]
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