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Gene Review

SH3BP4  -  SH3-domain binding protein 4

Homo sapiens

Synonyms: BOG25, EH-binding protein 10, EHB10, SH3 domain-binding protein 4, TTP, ...
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Disease relevance of SH3BP4


High impact information on SH3BP4


Biological context of SH3BP4

  • SH3BP4 homologies and consensus sequence sites indicate that it may be involved in a newly identified cascade of proteins involved in endocytosis, intracellular sorting, and the cell cycle [4].
  • Consensus sequence domains identified in SH3BP4 include a SH3 domain, three N-P-F motifs, a P-X-X-P motif noted for binding to SH3 domains, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site [4].
  • The deduced sequence for SH3BP4 was found to contain a 963-amino-acid open reading frame that has homology to a 479-amino-acid protein in GenBank called EH-binding protein [4].
  • In contrast, transient overexpression of TTP resulted in decreased levels of the same genes supporting its role in regulating macrophage gene expression [5].
  • These findings suggest that the accelerating effect of TDP and TTP may be due to the binding of thiamine phosphate to the regulatory site of myosin followed by a change in its physical chemical property, rather than due to the competitive binding of thiamine phosphate to the catalytically activity site of myosin [6].

Anatomical context of SH3BP4

  • CONCLUSIONS: These studies show that SH3BP4 is expressed in the RPE and neural retina in vivo, and in ARPE-19, Y79, and COS-7 cell lines [1].
  • Subsequent microscopy analyses show that SH3BP4 fusion proteins localize to the plasma membrane and the nuclear periphery [1].
  • Protein expression of SH3BP4 was determined using western analysis of multiple cell lines and dissected retinal tissue [1].
  • SH3BP4 endogenous and fusion proteins were found to localize to both membrane and nuclear fractions but not the cytosol in subcellular fractionation experiments [1].
  • Nuclear and plasma membrane localization of SH3BP4 in retinal pigment epithelial cells [1].

Associations of SH3BP4 with chemical compounds

  • RESULTS: /st> Propofol 1.5-2 mg kg(-1) significantly attenuated PSV from 5.64 (1.17) to 4.66 (0.55) cm s(-1) (P < 0.0001) and TTD from 10.2 (2.1) to 8.5 (1.4) mm (P = 0.0091), whereas TTP was unchanged [all data: mean (sd)] [7].

Analytical, diagnostic and therapeutic context of SH3BP4

  • Although the sample size is small, the TTP and survival times are longer than those previously reported in other DPG series [8].
  • Fifty-nine consecutive patients with chronic unexplained excessive throat phlegm, transparent in 33 patients (TTP) and yellow in 26 patients (YTP), underwent gastrointestinal endoscopy, 24-hr dual esophageal pH monitoring, and fiberoptic DGER monitoring [9].


  1. Nuclear and plasma membrane localization of SH3BP4 in retinal pigment epithelial cells. Khanobdee, K., Kolberg, J.B., Dunlevy, J.R. Mol. Vis. (2004) [Pubmed]
  2. Transient left ventricular dysfunction (tako-tsubo phenomenon): Findings and potential pathophysiological mechanisms. St??llberger, C., Finsterer, J., Schneider, B. The Canadian journal of cardiology. (2006) [Pubmed]
  3. TTP specifically regulates the internalization of the transferrin receptor. Tosoni, D., Puri, C., Confalonieri, S., Salcini, A.E., De Camilli, P., Tacchetti, C., Di Fiore, P.P. Cell (2005) [Pubmed]
  4. Cloning, chromosomal localization, and characterization of cDNA from a novel gene, SH3BP4, expressed by human corneal fibroblasts. Dunlevy, J.R., Berryhill, B.L., Vergnes, J.P., SundarRaj, N., Hassell, J.R. Genomics (1999) [Pubmed]
  5. Atherosclerotic plaque macrophage transcriptional regulators are expressed in blood and modulated by tristetraprolin. Patino, W.D., Kang, J.G., Matoba, S., Mian, O.Y., Gochuico, B.R., Hwang, P.M. Circ. Res. (2006) [Pubmed]
  6. Thiamine triphosphatase activity of myosin and accelerating effect of thiamine di- and tri-phosphates on superprecipitation of actomyosin. Murai, A., Katsura, E. J. Nutr. Sci. Vitaminol. (1975) [Pubmed]
  7. Propofol reduces tissue-Doppler markers of left ventricle function: a transthoracic echocardiographic study. Larsen, J.R., Torp, P., Norrild, K., Sloth, E. British journal of anaesthesia (2007) [Pubmed]
  8. Osmotic blood-brain barrier disruption chemotherapy for diffuse pontine gliomas. Hall, W.A., Doolittle, N.D., Daman, M., Bruns, P.K., Muldoon, L., Fortin, D., Neuwelt, E.A. J. Neurooncol. (2006) [Pubmed]
  9. The role of (duodeno)gastroesophagopharyngeal reflux in unexplained excessive throat phlegm. Poelmans, J., Feenstra, L., Tack, J. Dig. Dis. Sci. (2005) [Pubmed]
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