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Gene Review

Tnfsf18  -  tumor necrosis factor (ligand) superfamily...

Mus musculus

Synonyms: GITR ligand, GITRL, Gitrl, Glucocorticoid-induced TNF-related ligand, Tumor necrosis factor ligand superfamily member 18


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Disease relevance of Tnfsf18

  • This report evaluates the role of interaction between glucocorticoid-induced tumor necrosis factor receptor (GITR) and GITR ligand (GITR-L) in the immuno-inflammatory response to infection with herpes simplex virus (HSV) [1].
  • B cells suppressed autoimmunity by maintenance of regulatory T cells via GITRL [2]

High impact information on Tnfsf18

  • RT-PCR and mAb staining revealed mouse GITR ligand expression in dendritic cells, macrophages, and B cells [3].
  • GITR-mediated stimulation induced by anti-GITR mAb DTA-1 or GITR ligand transfectants efficiently augmented the proliferation of both CD25-CD4+ and CD25+CD4+ T cells under the limited dose of anti-CD3 stimulation [4].
  • In vivo kinetics of GITR and GITR ligand expression and their functional significance in regulating viral immunopathology [1].
  • GITR and GITR ligand were expressed constitutively on the surface of Raw 264.7 macrophage cell line and murine peritoneal macrophages [5].
  • We have inserted the sequences for natural, membrane-bound GITR-ligand (GITR-L) and a truncated secreted form of GITR-L (GITR-Lsol) into the adenovirus-5 genome [6].
  • B cells suppressed autoimmunity by maintenance of regulatory T cells via GITRL [2]  

Anatomical context of Tnfsf18


Associations of Tnfsf18 with chemical compounds


  1. In vivo kinetics of GITR and GITR ligand expression and their functional significance in regulating viral immunopathology. Suvas, S., Kim, B., Sarangi, P.P., Tone, M., Waldmann, H., Rouse, B.T. J. Virol. (2005) [Pubmed]
  2. A novel IL-10-independent regulatory role for B cells in suppressing autoimmunity by maintenance of regulatory T cells via GITR ligand. Ray, A., Basu, S., Williams, C.B., Salzman, N.H., Dittel, B.N. J. Immunol. (2012) [Pubmed]
  3. Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells. Tone, M., Tone, Y., Adams, E., Yates, S.F., Frewin, M.R., Cobbold, S.P., Waldmann, H. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  4. Costimulation via glucocorticoid-induced TNF receptor in both conventional and CD25+ regulatory CD4+ T cells. Kanamaru, F., Youngnak, P., Hashiguchi, M., Nishioka, T., Takahashi, T., Sakaguchi, S., Ishikawa, I., Azuma, M. J. Immunol. (2004) [Pubmed]
  5. Recombinant glucocorticoid induced tumor necrosis factor receptor (rGITR) induces NOS in murine macrophage. Shin, H.H., Lee, M.H., Kim, S.G., Lee, Y.H., Kwon, B.S., Choi, H.S. FEBS Lett. (2002) [Pubmed]
  6. Bypassing tumor-associated immune suppression with recombinant adenovirus constructs expressing membrane bound or secreted GITR-L. Calmels, B., Paul, S., Futin, N., Ledoux, C., Stoeckel, F., Acres, B. Cancer Gene Ther. (2005) [Pubmed]
  7. Genetic and pharmacological inhibition of GITR-GITRL interaction reduces chronic lung injury induced by bleomycin instillation. Cuzzocrea, S., Ronchetti, S., Genovese, T., Mazzon, E., Agostini, M., Di Paola, R., Esposito, E., Mui??, C., Nocentini, G., Riccardi, C. FASEB J. (2007) [Pubmed]
  8. Soluble glucocorticoid-induced TNF receptor (sGITR) induces inflammation in mice. Shin, H.H., Kim, S.G., Lee, M.H., Suh, J.H., Kwon, B.S., Choi, H.S. Exp. Mol. Med. (2003) [Pubmed]
  9. Macaque Multimeric Soluble CD40 Ligand and GITR Ligand Constructs Are Immunostimulatory Molecules In Vitro. Stone, G.W., Barzee, S., Snarsky, V., Spina, C.A., Lifson, J.D., Pillai, V.K., Amara, R.R., Villinger, F., Kornbluth, R.S. Clin. Vaccine Immunol. (2006) [Pubmed]
  10. Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy. Grohmann, U., Volpi, C., Fallarino, F., Bozza, S., Bianchi, R., Vacca, C., Orabona, C., Belladonna, M.L., Ayroldi, E., Nocentini, G., Boon, L., Bistoni, F., Fioretti, M.C., Romani, L., Riccardi, C., Puccetti, P. Nat. Med. (2007) [Pubmed]
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