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Gene Review

TNFSF18  -  tumor necrosis factor (ligand) superfamily...

Homo sapiens

Synonyms: AITRL, Activation-inducible TNF-related ligand, GITRL, Glucocorticoid-induced TNF-related ligand, TL6, ...


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Disease relevance of TNFSF18


High impact information on TNFSF18


Chemical compound and disease context of TNFSF18


Biological context of TNFSF18


Anatomical context of TNFSF18


Associations of TNFSF18 with chemical compounds

  • Genetic and pharmacological inhibition of GITR-GITRL interaction reduces chronic lung injury induced by bleomycin instillation [8].

Regulatory relationships of TNFSF18


Other interactions of TNFSF18

  • RESULTS: Soluble hGITR (shGITR) stimulated FLSs to produce MMP-13, and blockade of hGITRL reduced this effect [10].

Analytical, diagnostic and therapeutic context of TNFSF18


  1. Glucocorticoid-induced Tumour Necrosis Factor Receptor (GITR) and its Ligand (GITRL) in Atopic Dermatitis. Baumgartner-Nielsen, J., Vestergaard, C., Thestrup-Pedersen, K., Deleuran, M., Deleuran, B. Acta Derm. Venereol. (2006) [Pubmed]
  2. A novel IL-10-independent regulatory role for B cells in suppressing autoimmunity by maintenance of regulatory T cells via GITR ligand. Ray, A., Basu, S., Williams, C.B., Salzman, N.H., Dittel, B.N. J. Immunol. (2012) [Pubmed]
  3. Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL). Hanabuchi, S., Watanabe, N., Wang, Y.H., Wang, Y.H., Ito, T., Shaw, J., Cao, W., Qin, F.X., Liu, Y.J. Blood (2006) [Pubmed]
  4. Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. Gurney, A.L., Marsters, S.A., Huang, R.M., Pitti, R.M., Mark, D.T., Baldwin, D.T., Gray, A.M., Dowd, A.D., Brush, A.D., Heldens, A.D., Schow, A.D., Goddard, A.D., Wood, W.I., Baker, K.P., Godowski, P.J., Ashkenazi, A. Curr. Biol. (1999) [Pubmed]
  5. Multimeric soluble CD40 ligand and GITR ligand as adjuvants for human immunodeficiency virus DNA vaccines. Stone, G.W., Barzee, S., Snarsky, V., Kee, K., Spina, C.A., Yu, X.F., Kornbluth, R.S. J. Virol. (2006) [Pubmed]
  6. Constitutive and cytokine-induced GITR ligand expression on human retinal pigment epithelium and photoreceptors. Kim, B.J., Li, Z., Fariss, R.N., Shen, d.e. .F., Mahesh, S.P., Egwuagu, C., Yu, C.R., Nagineni, C.N., Chan, C.C., Nussenblatt, R.B. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  7. Cloning and characterization of GITR ligand. Kim, J.D., Choi, B.K., Bae, J.S., Lee, U.H., Han, I.S., Lee, H.W., Youn, B.S., Vinay, D.S., Kwon, B.S. Genes Immun. (2003) [Pubmed]
  8. Genetic and pharmacological inhibition of GITR-GITRL interaction reduces chronic lung injury induced by bleomycin instillation. Cuzzocrea, S., Ronchetti, S., Genovese, T., Mazzon, E., Agostini, M., Di Paola, R., Esposito, E., Mui??, C., Nocentini, G., Riccardi, C. FASEB J. (2007) [Pubmed]
  9. Expression of GITR ligand abrogates immunosuppressive function of ocular tissue and differentially modulates inflammatory cytokines and chemokines. Mahesh, S.P., Li, Z., Liu, B., Fariss, R.N., Nussenblatt, R.B. Eur. J. Immunol. (2006) [Pubmed]
  10. Induction of MMP-13 expression by soluble human glucocorticoid-induced tumor necrosis factor receptor in fibroblast-like synovial cells. Kim, S.J., Shin, H.H., Park, S.Y., Lee, D.S., Lee, E.A., Cho, S.D., Cho, H.R., Miyazawa, K., Choi, H.S. Osteoarthr. Cartil. (2006) [Pubmed]
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