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Gene Review

PTGS1  -  prostaglandin-endoperoxide synthase 1...

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Disease relevance of PTGS1


High impact information on PTGS1


Chemical compound and disease context of PTGS1


Biological context of PTGS1


Anatomical context of PTGS1


Associations of PTGS1 with chemical compounds


Physical interactions of PTGS1


Regulatory relationships of PTGS1


Other interactions of PTGS1


Analytical, diagnostic and therapeutic context of PTGS1

  • METHODS: Northern blot analysis was used to quantify COX-1 and COX-2 mRNA expression in primary cultures of bovine chondrocytes and prostaglandin production to evaluate COX activity [30].
  • The time- and concentration-dependent induction of COX-2 expression in the BAECs was evaluated by a kinetic profile (HPLC analysis) and detected by Western-Blot analysis using polyclonal antibodies against COX-1 and COX-2 [15].
  • COX-1 and COX-2 gene and protein expression were examined by RT-PCR and Western analysis, respectively; prostanoid measurements were made by gas chromatography-mass spectrometry, and COX activity was studied after a 30-min incubation with 30 microM arachidonic acid [31].
  • After detergent extraction, the enzyme had hydrodynamic properties indistinguishable from native bovine COX-1 and corresponded to the enzyme dimer as measured with size-exclusion chromatography [32].
  • Their effect was quantified by measurement of PGE(2) and PGF(2alpha) production by ELISA and induction of cyclooxygenase (COX-2) by Western and Northern analysis and correlated with antiviral activity previously reported [33].


  1. COX-2 inhibitors selectively block prostacyclin synthesis in endotoxin-exposed vascular smooth muscle cells. Schildknecht, S., Bachschmid, M., Baumann, A., Ullrich, V. FASEB J. (2004) [Pubmed]
  2. Anti-inflammatory effects of specific cyclooxygenase 2,5-lipoxygenase, and inducible nitric oxide synthase inhibitors on experimental autoimmune anterior uveitis (EAAU). Bora, N.S., Sohn, J.H., Bora, P.S., Kaplan, H.J., Kulkarni, P. Ocul. Immunol. Inflamm. (2005) [Pubmed]
  3. Differences in prostaglandin metabolism in cultured aortic and pulmonary arterial endothelial cells exposed to acute and chronic hypoxia. Farber, H.W., Barnett, H.F. Circ. Res. (1991) [Pubmed]
  4. Effect of blood and albumin on pulmonary hypertension and edema in perfused rabbit lungs. Kraft, S.A., Fujishima, S., McGuire, G.P., Thompson, J.S., Raffin, T.A., Pearl, R.G. J. Appl. Physiol. (1995) [Pubmed]
  5. Bovine lactoferrin has a nitric oxide-dependent hypotensive effect in rats. Hayashida, K., Takeuchi, T., Ozaki, T., Shimizu, H., Ando, K., Miyamoto, A., Harada, E. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2004) [Pubmed]
  6. Hypoxia-reoxygenation triggers coronary vasospasm in isolated bovine coronary arteries via tyrosine nitration of prostacyclin synthase. Zou, M.H., Bachschmid, M. J. Exp. Med. (1999) [Pubmed]
  7. Protection of rabbit lungs from endotoxin injury by in vivo hyperexpression of the prostaglandin G/H synthase gene. Conary, J.T., Parker, R.E., Christman, B.W., Faulks, R.D., King, G.A., Meyrick, B.O., Brigham, K.L. J. Clin. Invest. (1994) [Pubmed]
  8. Concentrations of prostaglandin endoperoxide synthase and prostaglandin I2 synthase in the endothelium and smooth muscle of bovine aorta. DeWitt, D.L., Day, J.S., Sonnenburg, W.K., Smith, W.L. J. Clin. Invest. (1983) [Pubmed]
  9. Production of arachidonic acid metabolites by endothelial cells in hyperoxia. Jackson, R.M., Chandler, D.B., Fulmer, J.D. J. Appl. Physiol. (1986) [Pubmed]
  10. Anti-inflammatory effects of betamethasone phosphate, dexamethasone phosphate and indomethacin on rabbit ocular inflammation induced by bovine serum albumin. Kulkarni, P.S., Bhattacherjee, P., Eakins, K.E., Srinivasan, B.D. Curr. Eye Res. (1981) [Pubmed]
  11. Antitumor activity in a rat mammary adenocarcinoma: the effect of cyclooxygenase inhibitors and immunization against prostaglandin E2. Karmali, R.A., Marsh, J. Prostaglandins, leukotrienes, and medicine. (1986) [Pubmed]
  12. The role of cyclooxygenase and 5-lipoxygenase metabolites in potentiated endothelin-1-evoked contractions in bovine bronchi. Nally, J.E., Bunton, D.C., Martin, D., Thomson, N.C. Pulmonary pharmacology. (1996) [Pubmed]
  13. Expression of cyclooxygenases 1 and 2 and prostaglandin E synthase in bovine endometrial tissue during the estrous cycle. Arosh, J.A., Parent, J., Chapdelaine, P., Sirois, J., Fortier, M.A. Biol. Reprod. (2002) [Pubmed]
  14. Differential expression of cyclooxygenase 1 and cyclooxygenase 2 in the bovine oviduct. Odau, S., Gabler, C., Holder, C., Einspanier, R. J. Endocrinol. (2006) [Pubmed]
  15. In-vitro test system for the evaluation of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibitors based on a single HPLC run with UV detection using bovine aortic coronary endothelial cells (BAECs). Dannhardt, G., Ulbrich, H. Inflamm. Res. (2001) [Pubmed]
  16. Cyclooxygenase expression in bovine aortic endothelial cells exposed to cyclic strain. Kito, H., Yokoyama, C., Inoue, H., Tanabe, T., Nakajima, N., Sumpio, B.E. Endothelium (1998) [Pubmed]
  17. Interferon-tau blocks the stimulatory effect of tumor necrosis factor-alpha on prostaglandin F2alpha synthesis by bovine endometrial stromal cells. Okuda, K., Kasahara, Y., Murakami, S., Takahashi, H., Woclawek-Potocka, I., Skarzynski, D.J. Biol. Reprod. (2004) [Pubmed]
  18. Accumulation of cyclooxygenase-2 gene transcripts in uterine tissues of pregnant and parturient cows: stimulation by oxytocin. Fuchs, A.R., Rust, W., Fields, M.J. Biol. Reprod. (1999) [Pubmed]
  19. Differential regulation of cyclooxygenase isoenzymes by cAMP-elevating agents. Samokovlisky, A., Rimon, G., Danon, A. Eur. J. Pharmacol. (1999) [Pubmed]
  20. Tumor necrosis factor-alpha induces cyclooxygenase-2 expression and prostaglandin release in brain microvessel endothelial cells. Mark, K.S., Trickler, W.J., Miller, D.W. J. Pharmacol. Exp. Ther. (2001) [Pubmed]
  21. Inhibition of prostaglandin F2alpha synthesis and oxytocin receptor by progesterone antagonists in bovine endometrial cells in vitro. Goff, A.K., Jamshidi, A.A., Kombé, A. Steroids (2006) [Pubmed]
  22. Flavan-3-ols isolated from some medicinal plants inhibiting COX-1 and COX-2 catalysed prostaglandin biosynthesis. Noreen, Y., Serrano, G., Perera, P., Bohlin, L. Planta Med. (1998) [Pubmed]
  23. Effect of ebselen on IL-1-induced alterations in cartilage metabolism. Pratta, M.A., Ackerman, N.R., Arner, E.C. Inflamm. Res. (1998) [Pubmed]
  24. Prostaglandin H synthase: protein synthesis-independent regulation in bovine aortic endothelial cells. Rosenstock, M., Danon, A., Rimon, G. Am. J. Physiol. (1997) [Pubmed]
  25. Vascular endothelial growth factor/vascular permeability factor enhances vascular permeability via nitric oxide and prostacyclin. Murohara, T., Horowitz, J.R., Silver, M., Tsurumi, Y., Chen, D., Sullivan, A., Isner, J.M. Circulation (1998) [Pubmed]
  26. Expression of microsomal prostaglandin E synthase in bovine endometrium: coexpression with cyclooxygenase type 2 and regulation by interferon-tau. Parent, J., Chapdelaine, P., Sirois, J., Fortier, M.A. Endocrinology (2002) [Pubmed]
  27. Peroxynitrite increases iNOS through NF-kappaB and decreases prostacyclin synthase in endothelial cells. Cooke, C.L., Davidge, S.T. Am. J. Physiol., Cell Physiol. (2002) [Pubmed]
  28. Evaluation of the contribution of cyclooxygenase 1 and cyclooxygenase 2 to the production of PGE2 and PGF2 alpha in epithelial cells from bovine endometrium. Parent, J., Villeneuve, C., Fortier, M.A. Reproduction (2003) [Pubmed]
  29. Follicle-stimulating hormone receptor and its messenger ribonucleic acid are present in the bovine cervix and can regulate cervical prostanoid synthesis. Mizrachi, D., Shemesh, M. Biol. Reprod. (1999) [Pubmed]
  30. Regulation of cyclooxygenase-2 expression in bovine chondrocytes in culture by interleukin 1alpha, tumor necrosis factor-alpha, glucocorticoids, and 17beta-estradiol. Morisset, S., Patry, C., Lora, M., de Brum-Fernandes, A.J. J. Rheumatol. (1998) [Pubmed]
  31. NO regulates LPS-stimulated cyclooxygenase gene expression and activity in pulmonary artery endothelium. Chen, J.X., Berry, L.C., Christman, B.W., Tanner, M., Myers, P.R., Meyrick, B.O. Am. J. Physiol. Lung Cell Mol. Physiol. (2001) [Pubmed]
  32. Comparison of recombinant cyclooxygenase-2 to native isoforms: aspirin labeling of the active site. Wennogle, L.P., Liang, H., Quintavalla, J.C., Bowen, B.R., Wasvary, J., Miller, D.B., Allentoff, A., Boyer, W., Kelly, M., Marshall, P. FEBS Lett. (1995) [Pubmed]
  33. Influence of different isoforms of recombinant trophoblastic interferons on prostaglandin production in cultured bovine endometrial cells. Parent, J., Villeneuve, C., Alexenko, A.P., Ealy, A.D., Fortier, M.A. Biol. Reprod. (2003) [Pubmed]
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