Disease relevance of Slc45a1

• Together, our results indicate that Past-A is a brain-specific glucose transporter that may represent an adaptation mechanism regulating sugar homeostasis in neuronal cells after hypercapnia [1].
• On the contrary, we observed a significant decrease (p = 0.03) in the cumulative incidence of intestinal adenomas, but not adenocarcinomas, in the pasta group compared with the sucrose group (intestinal adenoma incidence in the pasta group was 31% compared with 63% in the sucrose group, 46% in the bolus group, and 37% in the glucose group) [2].

High impact information on Slc45a1

• In this study, we evaluated quantitatively the impairment of skilled forelimb use after unilateral ablation of the striatal interneurons using a pasta matrix reaching task in rats [3].
• Power Reaching rats were trained to grasp and break progressively larger bundles of dried pasta strands with their preferred forelimb [4].
• In the present study, skilled reaching for food located on a shelf and spontaneous grasping, handling and eating pieces of pasta were video-recorded and analyzed in control rats, rats with unilateral ibotenic acid lesions of the red nucleus (RN), unilateral pyramidal tract lesions (PT) and combined lesions [5].
• In conclusion, these results do not support the hypothesis that sucrose boluses or carbohydrates with a high GI stimulate colon carcinogenesis, but they indicate that foods such as pasta may exert a protective effect [2].
• Here, we report cloning and characterization of a novel gene called proton-associated sugar transporter-A (Past-A), which is induced in the brain after hypercapnia and mediates glucose uptake along the pH gradient [1].

Biological context of Slc45a1

• Transient transfection of Past-A in COS-7 cells leads to the expression of a membrane-associated 82 kDa protein that possesses a glucose transport activity [1].

Anatomical context of Slc45a1

• Skilled forelimb reaching for pasta guided by tactile input in the rat as measured by accuracy, spatial adjustments, and force [6].

Associations of Slc45a1 with chemical compounds

• Impairment of skilled forelimb use after ablation of striatal interneurons expressing substance P receptors in rats: an analysis using a pasta matrix reaching task [3].
• Hypoglycemic effect and protein nutritive quality of soy and methionine-supplemented whole durum pasta products [7].

Analytical, diagnostic and therapeutic context of Slc45a1

• The present study addressed this question by allowing rats to reach through a slot for rigidly held pieces of uncooked pasta of varying thickness, which could be oriented vertically or horizontally from different points around the slot and which were attached to a force transducer [6].

References