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Gene Review

SLC45A1  -  solute carrier family 45, member 1

Homo sapiens

Synonyms: DNB5, DNb-5, Deleted in neuroblastoma 5 protein, PAST-A, Proton-associated sugar transporter A, ...
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Disease relevance of SLC45A1

  • METHODS: Thirty-two patients with localized prostate adenocarcinoma consumed tomato sauce-based pasta dishes for the 3 weeks (30 mg of lycopene per day) preceding their scheduled radical prostatectomy [1].
  • We examined the effects of consumption of tomato sauce-based pasta dishes on lycopene uptake, oxidative DNA damage, and prostate-specific antigen (PSA) levels in patients already diagnosed with prostate cancer [1].
  • Moreover, even modest weight gains abolished the relative improvement in the insulinogenic index in the rye bread and pasta group compared with the oat and wheat bread and potato group (P for the interaction between weight change and group = 0.019) [2].
  • A 5-year-old girl with peanut sensitivity experienced urticaria and angioedema after ingesting a spaghetti-like pasta fortified with sweet lupine seed flour [3].
  • Although an increase of 1 standard deviation in carbohydrate was marginally associated with risk of breast cancer, relative risk (RR) 1.31 (95% CI, 0.98, 1.75), there were no significant associations with fibre, 1.08 (0.92, 1.26), GI, 0.98 (0.88, 1.10) or GL, 1.19 (0.93, 1.52) or with carbohydrate foods (bread, rice, pasta) [4].

Psychiatry related information on SLC45A1


High impact information on SLC45A1

  • Endocytosis and pasta [7].
  • Interestingly, we found that the fragments identical or equivalent to the immunodominant 33mer fragment are encoded by alpha-gliadin genes on the wheat chromosome 6D and thus absent from gluten of diploid einkorn (AA) and even certain cultivars of the tetraploid (AABB) pasta wheat [8].
  • In their celebrated experiment, Fermi, Pasta, and Ulam (FPU) [Los Alamos Report No. LA-1940, 1955] observed that in simple one-dimensional nonlinear atomic chains the energy must not always be equally shared among the modes [9].
  • CONCLUSIONS: Rye bread and pasta-based carbohydrate modification enhances early insulin secretion in persons with the metabolic syndrome, which may lower the risk of deteriorating glucose tolerance and development of type 2 diabetes [2].
  • The subjects were randomly assigned to 12-wk diets in which either rye bread and pasta or oat and wheat bread and potato were the main carbohydrate sources (34% and 37% of energy intake, respectively) [2].

Chemical compound and disease context of SLC45A1


Biological context of SLC45A1

  • RESULTS: Glucose responses and the rate of gastric emptying after consumption of the 2 rye breads and pasta did not differ from those after consumption of white wheat bread [12].
  • High glycemic index foods, such as white bread, increased the risk of breast cancer (OR = 1.3) while the intake of pasta, a medium glycemic index food, seemed to have no influence (OR = 1.0) [13].
  • RESULTS: We describe the Protein Active Site Template Acquisition (PASTA) system, which addresses these problems by performing automatic extraction of information relating to the roles of specific amino acid residues in protein molecules from online scientific articles and abstracts [14].
  • The PASTA-domain STPKs are found in the actinobacteria and firmicutes and, as exemplified by PknB of Mycobacterium tuberculosis, they are functionally implicated in aspects of growth, cell division, and development [10].
  • As a public health strategy to help prevent neural tube defect-affected pregnancies, enriched flour and pasta in the United States and Canada are being fortified with folic acid, and women are being advised to take supplementary folic acid around the time of pregnancy to ensure an adequate intake [15].

Anatomical context of SLC45A1

  • The quantitative data on pasta sticks retrieved indicated that forelimb extension and movement radius around the shoulder joint was reduced by 6-OHDA treatment and did not improve after chronic L-dopa treatment [16].
  • Use of tomato plastids in pasta sauces and rice dishes, salsa, and extrusion products would increase the nutritional value of the product [17].
  • Following a standard arthroscopic examination of the articular portion of the shoulder joint, the PASTA lesion is identified [18].
  • A common method of treating PASTA (partial articular surface tendon avulsion) lesions involves completing the tear followed by arthroscopic repair [18].
  • RESULTS: Time trends in reported food consumption associated with the more favourable gynoid distribution of adipose tissue were increased use of vegetable oil, pasta and 1.5% fat milk [19].

Associations of SLC45A1 with chemical compounds

  • The influence of pasta cooking time on starch digestion and plasma glucose and insulin responses was studied in 12 healthy subjects [20].
  • The test products were whole-kernel rye bread, whole-meal rye bread containing oat beta-glucan concentrate, dark durum wheat pasta, and wheat bread made from white wheat flour [12].
  • The absorption of folic acid in fortified white and whole-wheat bread, rice, or pasta or in solution was evaluated in human subjects with use of a single-dose, dual-label, stable-isotope protocol that did not involve prior loading of subjects with nonlabeled folate [21].
  • 13C in CO2 and plasma glucose, metabolites and insulin concentrations, carbohydrates, and lipid oxidation were measured after ingestion of 76 g glucose equivalent of crackers, pasta, or polenta [22].
  • Chronic levodopa therapy does not improve skilled reach accuracy or reach range on a pasta matrix reaching task in 6-OHDA dopamine-depleted (hemi-Parkinson analogue) rats [16].

Regulatory relationships of SLC45A1


Other interactions of SLC45A1

  • Hybridization screening resulted in the rapid and comprehensive identification of partial cDNAs of which a portion comprised two novel candidate genes, termed DNB1/ARPh and DNB5, which encode putative proteins of 1011 and 447 amino acids, respectively [24].
  • In a crossover study, glucose, insulin, GLP-1, and GIP concentrations were monitored for 6 h after consumption of glucose, uncooked cornstarch (UCCS) or corn pasta in 7 healthy men [25].
  • Two PC were identified: PC1 reflects a 'vegetable-based' diet with an emphasis on foods of plant origin, rice, pasta and other grain rather than on margarine, potatoes and non-alcoholic beverages [26].
  • Stepwise multiple regression was used to determine the factors associated with the percentage of income allocated to food (PFX) and the percentage of the food budget allocated to (1) maize, beans, and chile (TRAD); (2) meat, milk, and fruit (LUX); and (3) bread, pasta, and snack foods (PROC) [27].
  • Postprandial lipid, glucose, insulin, and cholecystokinin responses in men fed barley pasta enriched with beta-glucan [28].

Analytical, diagnostic and therapeutic context of SLC45A1

  • BACKGROUND: The Mediterranean diet, containing olive oil, pasta, fruits, vegetables, fish, and wine, is associated with an unexpectedly low rate of cardiovascular events [29].
  • Immunoblotting studies of electrophoretically separated pasta extract and lupine seed flour proteins showed IgE-binding protein bands at approximately 21 kd and in the range of 35 to 55 kd molecular weight [3].
  • These results emphasize that food form rather than fiber may be important in determining the glycemic response and that pasta may be a useful source of carbohydrate in the diabetic diet [30].
  • Hydrogen and methane breath excretion was measured after pasta ingestion; plasma responses were compared with those of an equivalent oral glucose-tolerance test [20].
  • After adjustment for age, gender, body mass index (BMI), and total energy intake, significant positive associations were observed for pork consumption, while negative ones were observed for tomatoes, lemons and pasta [31].


  1. Oxidative DNA damage in prostate cancer patients consuming tomato sauce-based entrees as a whole-food intervention. Chen, L., Stacewicz-Sapuntzakis, M., Duncan, C., Sharifi, R., Ghosh, L., van Breemen, R., Ashton, D., Bowen, P.E. J. Natl. Cancer Inst. (2001) [Pubmed]
  2. Dietary carbohydrate modification enhances insulin secretion in persons with the metabolic syndrome. Laaksonen, D.E., Toppinen, L.K., Juntunen, K.S., Autio, K., Liukkonen, K.H., Poutanen, K.S., Niskanen, L., Mykkänen, H.M. Am. J. Clin. Nutr. (2005) [Pubmed]
  3. Adverse reaction to lupine-fortified pasta. Hefle, S.L., Lemanske, R.F., Bush, R.K. J. Allergy Clin. Immunol. (1994) [Pubmed]
  4. Dietary carbohydrate, fibre, glycaemic index, glycaemic load and the risk of postmenopausal breast cancer. Giles, G.G., Simpson, J.A., English, D.R., Hodge, A.M., Gertig, D.M., Macinnis, R.J., Hopper, J.L. Int. J. Cancer (2006) [Pubmed]
  5. Modelling the associations of BMI physical activity and diet with arterial blood pressure: some results from the Allied Dunbar National Fitness Survey. Nevill, A.M., Holder, R.L., Fentem, P.H., Rayson, M., Marshall, T., Cooke, C., Tuxworth, W. Ann. Hum. Biol. (1997) [Pubmed]
  6. Change in diet, physical activity, and body weight in female college freshman. Butler, S.M., Black, D.R., Blue, C.L., Gretebeck, R.J. American journal of health behavior. (2004) [Pubmed]
  7. Endocytosis and pasta. Futter, C., Marsh, M. Trends Cell Biol. (1993) [Pubmed]
  8. Mapping of gluten T-cell epitopes in the bread wheat ancestors: implications for celiac disease. Molberg, O., Uhlen, A.K., Jensen, T., Flaete, N.S., Fleckenstein, B., Arentz-Hansen, H., Raki, M., Lundin, K.E., Sollid, L.M. Gastroenterology (2005) [Pubmed]
  9. q-Breathers in finite two- and three-dimensional nonlinear acoustic lattices. Ivanchenko, M.V., Kanakov, O.I., Mishagin, K.G., Flach, S. Phys. Rev. Lett. (2006) [Pubmed]
  10. Evolution of Transmembrane Protein Kinases Implicated in Coordinating Remodeling of Gram-Positive Peptidoglycan: Inside versus Outside. Jones, G., Dyson, P. J. Bacteriol. (2006) [Pubmed]
  11. Occupational allergic contact dermatitis due to curcumin food colour in a pasta factory worker. Kieć-Swierczyńska, M., Krecisz, B. Contact Derm. (1998) [Pubmed]
  12. Postprandial glucose, insulin, and incretin responses to grain products in healthy subjects. Juntunen, K.S., Niskanen, L.K., Liukkonen, K.H., Poutanen, K.S., Holst, J.J., Mykkänen, H.M. Am. J. Clin. Nutr. (2002) [Pubmed]
  13. Dietary glycemic index and glycemic load, and breast cancer risk: a case-control study. Augustin, L.S., Dal Maso, L., La Vecchia, C., Parpinel, M., Negri, E., Vaccarella, S., Kendall, C.W., Jenkins, D.J., Francesch, S. Ann. Oncol. (2001) [Pubmed]
  14. Protein structures and information extraction from biological texts: the PASTA system. Gaizauskas, R., Demetriou, G., Artymiuk, P.J., Willett, P. Bioinformatics (2003) [Pubmed]
  15. Do we need another randomized controlled trial of folic acid alone? Turner, L.A., Morrison, H., Prabhakaran, V.M. Epidemiology (Cambridge, Mass.) (2001) [Pubmed]
  16. Chronic levodopa therapy does not improve skilled reach accuracy or reach range on a pasta matrix reaching task in 6-OHDA dopamine-depleted (hemi-Parkinson analogue) rats. Metz, G.A., Farr, T., Ballermann, M., Whishaw, I.Q. Eur. J. Neurosci. (2001) [Pubmed]
  17. Isolation and composition of chromoplasts from tomatoes. Hansen, L.U., Chiu, M.C. J. Agric. Food Chem. (2005) [Pubmed]
  18. Double suture technique to delineate PASTA lesions. Sperling, J.W., Dahm, D.L. Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association. (2006) [Pubmed]
  19. Reported food intake and distribution of body fat: a repeated cross-sectional study. Krachler, B., Eliasson, M., Stenlund, H., Johansson, I., Hallmans, G., Lindahl, B. Nutrition journal (2006) [Pubmed]
  20. Pasta cooking time: influence on starch digestion and plasma glucose and insulin responses in healthy subjects. Bornet, F.R., Cloarec, D., Barry, J.L., Colonna, P., Gouilloud, S., Laval, J.D., Galmiche, J.P. Am. J. Clin. Nutr. (1990) [Pubmed]
  21. Absorption of folate from fortified cereal-grain products and of supplemental folate consumed with or without food determined by using a dual-label stable-isotope protocol. Pfeiffer, C.M., Rogers, L.M., Bailey, L.B., Gregory, J.F. Am. J. Clin. Nutr. (1997) [Pubmed]
  22. 13C appearance in plasma glucose and breath CO2 during feeding with naturally 13C-enriched starchy food in normal humans. Normand, S., Pachiaudi, C., Khalfallah, Y., Guilluy, R., Mornex, R., Riou, J.P. Am. J. Clin. Nutr. (1992) [Pubmed]
  23. In vitro starch digestibility and in vivo glucose response of gluten-free foods and their gluten counterparts. Berti, C., Riso, P., Monti, L.D., Porrini, M. European journal of nutrition. (2004) [Pubmed]
  24. Identification and characterization of novel genes located at the t(1;15)(p36.2;q24) translocation breakpoint in the neuroblastoma cell line NGP. Amler, L.C., Bauer, A., Corvi, R., Dihlmann, S., Praml, C., Cavenee, W.K., Schwab, M., Hampton, G.M. Genomics (2000) [Pubmed]
  25. The rate of intestinal glucose absorption is correlated with plasma glucose-dependent insulinotropic polypeptide concentrations in healthy men. Wachters-Hagedoorn, R.E., Priebe, M.G., Heimweg, J.A., Heiner, A.M., Englyst, K.N., Holst, J.J., Stellaard, F., Vonk, R.J. J. Nutr. (2006) [Pubmed]
  26. Dietary patterns among older Europeans: the EPIC-Elderly study. Bamia, C., Orfanos, P., Ferrari, P., Overvad, K., Hundborg, H.H., Tjønneland, A., Olsen, A., Kesse, E., Boutron-Ruault, M.C., Clavel-Chapelon, F., Nagel, G., Boffetta, P., Boeing, H., Hoffmann, K., Trichopoulos, D., Baibas, N., Psaltopoulou, T., Norat, T., Slimani, N., Palli, D., Krogh, V., Panico, S., Tumino, R., Sacerdote, C., Bueno-de-Mesquita, H.B., Ocké, M.C., Peeters, P.H., van Rossum, C.T., Quirós, J.R., Sánchez, M.J., Navarro, C., Barricarte, A., Dorronsoro, M., Berglund, G., Wirfält, E., Hallmans, G., Johansson, I., Bingham, S., Khaw, K.T., Spencer, E.A., Roddam, A.W., Riboli, E., Trichopoulou, A. Br. J. Nutr. (2005) [Pubmed]
  27. Migration, cash cropping and subsistence agriculture: relationships to household food expenditures in rural Mexico. Kaiser, L.L., Dewey, K.G. Social science & medicine (1982) (1991) [Pubmed]
  28. Postprandial lipid, glucose, insulin, and cholecystokinin responses in men fed barley pasta enriched with beta-glucan. Bourdon, I., Yokoyama, W., Davis, P., Hudson, C., Backus, R., Richter, D., Knuckles, B., Schneeman, B.O. Am. J. Clin. Nutr. (1999) [Pubmed]
  29. The postprandial effect of components of the Mediterranean diet on endothelial function. Vogel, R.A., Corretti, M.C., Plotnick, G.D. J. Am. Coll. Cardiol. (2000) [Pubmed]
  30. Glycemic response to wheat products: reduced response to pasta but no effect of fiber. Jenkins, D.J., Wolever, T.M., Jenkins, A.L., Lee, R., Wong, G.S., Josse, R. Diabetes Care (1983) [Pubmed]
  31. The influence of dietary patterns on the development of thyroid cancer. Markaki, I., Linos, D., Linos, A. Eur. J. Cancer (2003) [Pubmed]
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