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Gene Review:

Inhbb - inhibin beta-B

Rattus norvegicus

Synonyms: Activin beta-B chain, Inhibin beta B chain

Tena-Sempere, M. et al., Kobayashi, T. et al., Rivier, C. et al., Clifton, R.J. et al., Shaha, C. et al., et al.

Kobayashi, Niimi, Fukuoka, Hayakawa,

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High impact information on Inhbb

Inhibin-betaA mRNA, and to a lesser extent, inhibin-betaB mRNA expression was rapidly induced in cultured SC [1].
Transcriptional regulation of inhibin beta B messenger ribonucleic acid levels in TM.4 or primary rat Sertoli cells by 8-bromo-cyclic adenosine monophosphate [2].
In this model, the abdominal testes showed a significant 2.5-fold increase in inhibin-alpha mRNA levels 5 days after EDS, but no effect was found in those of inhibin-betaB [3].
Inhibin-beta B mRNA was present in both testes and ovaries from 15 day pc onward [4].
The distribution of inhibin beta-B-subunit immunostaining in this epithelium was consistent with Sertoli cell localization similar to that of the alpha-subunit [5].

Anatomical context of Inhbb

Follistatin mRNA expression was identical to that of inhibin beta A, while inhibin beta B mRNA was maximally expressed in Sertoli cells at stages XIII-III [6].
These results indicate that the growth stimulatory action of peroxisome proliferators may be mediated via the decrease in activin A level and activity and suggest that the increases in follistatin as well as inhibin betaB and betaC chains may play a role in peroxisome proliferator-stimulated hepatocyte growth [7].
It is concluded that pachytene spermatocytes in vitro suppress Sertoli cell inhibin B secretion via factor-mediated suppression of inhibin beta B-subunit expression [8].

Associations of Inhbb with chemical compounds

The expression of inhibin beta B-subunit mRNAs was not influenced by FSH or testosterone [9].

Other interactions of Inhbb

In this model, a 5.0-fold increase in inhibin-alpha mRNA levels, similar to that found in intact animals, was detected 5 days after EDS administration, but the rise in inhibin-betaB levels was partially delayed [3].

Analytical, diagnostic and therapeutic context of Inhbb

At the end of the experiment, gonadal expression of inhibin-alpha, inhibin-beta A, and inhibin-beta B subunits was measured by S1 nuclease analysis and in situ hybridization [10].

References

Localization and cellular sources of activins in normal and fibrotic rat liver. De Bleser, P.J., Niki, T., Xu, G., Rogiers, V., Geerts, A. Hepatology (1997) [Pubmed]
Transcriptional regulation of inhibin beta B messenger ribonucleic acid levels in TM.4 or primary rat Sertoli cells by 8-bromo-cyclic adenosine monophosphate. Najmabadi, H., Rosenberg, L.A., Yuan, Q.X., Reyaz, G., Bhasin, S. Mol. Endocrinol. (1993) [Pubmed]
The pattern of inhibin/activin alpha- and betaB-subunit messenger ribonucleic acid expression in rat testis after selective Leydig cell destruction by ethylene dimethane sulfonate. Tena-Sempere, M., Kero, J., Rannikko, A., Yan, W., Huhtaniemi, I. Endocrinology (1999) [Pubmed]
Sex difference in the action of activin-A on cell proliferation of differentiating rat gonad. Kaipia, A., Toppari, J., Huhtaniemi, I., Paranko, J. Endocrinology (1994) [Pubmed]
Immunostainable inhibin subunits are in multiple types of testicular cells. Shaha, C., Morris, P.L., Chen, C.L., Vale, W., Bardin, C.W. Endocrinology (1989) [Pubmed]
Expression of inhibin beta A and beta B, follistatin and activin-A receptor messenger ribonucleic acids in the rat seminiferous epithelium. Kaipia, A., Penttilä, T.L., Shimasaki, S., Ling, N., Parvinen, M., Toppari, J. Endocrinology (1992) [Pubmed]
Regulation of inhibin beta chains and follistatin mRNA levels during rat hepatocyte growth induced by the peroxisome proliferator di-n-butyl phthalate. Kobayashi, T., Niimi, S., Fukuoka, M., Hayakawa, T. Biol. Pharm. Bull. (2002) [Pubmed]
Pachytene spermatocytes in co-culture inhibit rat Sertoli cell synthesis of inhibin beta B-subunit and inhibin B but not the inhibin alpha-subunit. Clifton, R.J., O'Donnell, L., Robertson, D.M. J. Endocrinol. (2002) [Pubmed]
Effects of FSH and testosterone on highly purified rat Sertoli cells: inhibin alpha-subunit mRNA expression and inhibin secretion are enhanced by FSH but not by testosterone. Toebosch, A.M., Robertson, D.M., Klaij, I.A., de Jong, F.H., Grootegoed, J.A. J. Endocrinol. (1989) [Pubmed]
Possible involvement of inhibin in altered follicle-stimulating hormone (FSH) secretion during dissociated luteinizing hormone (LH) and FSH release: unilateral castration and experimental cryptorchidism. Rivier, C., Meunier, H., Roberts, V., Vale, W. Biol. Reprod. (1989) [Pubmed]

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