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Gene Review

INHBB  -  inhibin, beta B

Homo sapiens

Synonyms: Activin beta-B chain, Inhibin beta B chain
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Disease relevance of INHBB


High impact information on INHBB


Biological context of INHBB

  • Over 6.7 kb of the INHBB gene was sequenced from a porcine genomic cosmid clone and found to contain two microsatellites, one in intron 1 and the other in the 3'-untranslated region [4].

Associations of INHBB with chemical compounds

  • Furthermore, INHBB expression was positively correlated to total (p<0.001) and subcutaneous (p<0.01) adipose tissue areas and serum levels of fasting insulin (p<0.01) and cholesterol (p<0.05) [1].


  1. The expression of inhibin beta B is high in human adipocytes, reduced by weight loss, and correlates to factors implicated in metabolic disease. Sjöholm, K., Palming, J., Lystig, T.C., Jennische, E., Woodruff, T.K., Carlsson, B., Carlsson, L.M. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  2. BamHI RFLP of the inhibin beta B (INHBB) chain gene on chromosome 2. Chenevix-Trench, G., Southall, M., Healey, S., Stewart, A., Forage, R., Martin, N.G. Nucleic Acids Res. (1990) [Pubmed]
  3. Candidate gene markers for sperm quality and fertility of boar. Lin, C.L., Ponsuksili, S., Tholen, E., Jennen, D.G., Schellander, K., Wimmers, K. Anim. Reprod. Sci. (2006) [Pubmed]
  4. Molecular cloning of the porcine inhibin-betaB gene and reassignment to chromosome 15. Nonneman, D., Rohrer, G.A. Anim. Genet. (2003) [Pubmed]
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