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Gene Review:

INHBB - inhibin, beta B

Homo sapiens

Synonyms: Activin beta-B chain, Inhibin beta B chain

Sjöholm, K. et al., Nonneman, D. et al., Lin, C.L. et al., Chenevix-Trench, G. et al.

Sjöholm, Palming, Lystig, Jennische, Woodruff, Carlsson, Carlsson, Nonneman, Rohrer,

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Disease relevance of INHBB

INHBB expression in adipose tissue was down regulated by diet-induced weight loss (p<0.001) [1].

High impact information on INHBB

BamHI RFLP of the inhibin beta B (INHBB) chain gene on chromosome 2 [2].
Inhibin beta B (INHBB; coding for the activin betaB subunit) was identified and high expression in adipocytes was confirmed by real-time PCR and immunohistochemistry [1].
In conclusion, INHBB expression was high in human adipocytes, reduced by weight loss and adipose tissue INHBB mRNA levels correlated to metabolic risk factors [1].
Analysis of variance revealed significant association of GNRHR with MOT (P = 0.0161), PDR (P = 0.0048) and ASR (P = 0.0201), INHBA was found to have significant effects on PDR (P = 0.0318) and ASR (P = 0.0067), INHBB was significant (P = 0.0360) for SCON trait [3].
The porcine inhibin-alpha, -betaA (INHBA) and -betaB (INHBB) subunit genes have previously been mapped to chromosomes 15, 18 and 12, respectively [4].

Biological context of INHBB

Over 6.7 kb of the INHBB gene was sequenced from a porcine genomic cosmid clone and found to contain two microsatellites, one in intron 1 and the other in the 3'-untranslated region [4].

Associations of INHBB with chemical compounds

Furthermore, INHBB expression was positively correlated to total (p<0.001) and subcutaneous (p<0.01) adipose tissue areas and serum levels of fasting insulin (p<0.01) and cholesterol (p<0.05) [1].

References

The expression of inhibin beta B is high in human adipocytes, reduced by weight loss, and correlates to factors implicated in metabolic disease. Sjöholm, K., Palming, J., Lystig, T.C., Jennische, E., Woodruff, T.K., Carlsson, B., Carlsson, L.M. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
BamHI RFLP of the inhibin beta B (INHBB) chain gene on chromosome 2. Chenevix-Trench, G., Southall, M., Healey, S., Stewart, A., Forage, R., Martin, N.G. Nucleic Acids Res. (1990) [Pubmed]
Candidate gene markers for sperm quality and fertility of boar. Lin, C.L., Ponsuksili, S., Tholen, E., Jennen, D.G., Schellander, K., Wimmers, K. Anim. Reprod. Sci. (2006) [Pubmed]
Molecular cloning of the porcine inhibin-betaB gene and reassignment to chromosome 15. Nonneman, D., Rohrer, G.A. Anim. Genet. (2003) [Pubmed]

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INHBB	Bos taurus
inhbb	Danio rerio
INHBB	Gallus gallus
INHBB	Macaca mulatta
Inhbb	Mus musculus
Inhbb	Rattus norvegicus

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