The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Inhba  -  inhibin beta-A

Rattus norvegicus

Synonyms: Activin beta-A chain, Inhibin beta A chain
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Inhba


High impact information on Inhba


Biological context of Inhba


Anatomical context of Inhba


Associations of Inhba with chemical compounds


Regulatory relationships of Inhba

  • In this model, a single dose of EDS (75 mg/kg BW, ip) induced a significant increase in testicular inhibin-alpha and -betaB mRNA levels 5 days after treatment (5.0- and 5.5-fold increases, respectively), whereas inhibin-betaA mRNA remained undetectable upon Northern hybridization in control and EDS-treated testes [14].

Other interactions of Inhba

  • Inhibin-beta A mRNA was seen in testes and mesonephroi in the male and in mesonephroi in the female of 15 and 18 day pc embryos [15].
  • Although these NTS cells contain multiple putative transmitters, we present evidence that activin, an inhibin-beta A dimer, plays a modulatory role in HPA axis function via facilitation of CRF release [16].

Analytical, diagnostic and therapeutic context of Inhba


  1. Dynamics and localization of activin A expression in rat gastric ulcers. Becker, J.C., Hertel, M., Markmann, A., Shahin, M., Werner, S., Domschke, W., Pohle, T. Scand. J. Gastroenterol. (2003) [Pubmed]
  2. Regulation of inhibin beta chains and follistatin mRNA levels during rat hepatocyte growth induced by the peroxisome proliferator di-n-butyl phthalate. Kobayashi, T., Niimi, S., Fukuoka, M., Hayakawa, T. Biol. Pharm. Bull. (2002) [Pubmed]
  3. Sequential patterns of inhibin subunit gene expression following hypoxic-ischemic injury in the rat brain. Lai, M., Sirimanne, E., Williams, C.E., Gluckman, P.D. Neuroscience (1996) [Pubmed]
  4. Localization and cellular sources of activins in normal and fibrotic rat liver. De Bleser, P.J., Niki, T., Xu, G., Rogiers, V., Geerts, A. Hepatology (1997) [Pubmed]
  5. Regulation of neural oxytocin gene expression by gonadal steroids in pubertal rats. Chibbar, R., Toma, J.G., Mitchell, B.F., Miller, F.D. Mol. Endocrinol. (1990) [Pubmed]
  6. Periovulatory changes in the expression of inhibin alpha-, beta A-, and beta B-subunits in hormonally induced immature female rats. Meunier, H., Roberts, V.J., Sawchenko, P.E., Cajander, S.B., Hsueh, A.J., Vale, W. Mol. Endocrinol. (1989) [Pubmed]
  7. Parallel gene expression monitoring using oligonucleotide probe arrays of multiple transcripts with an animal model of focal ischemia. Soriano, M.A., Tessier, M., Certa, U., Gill, R. J. Cereb. Blood Flow Metab. (2000) [Pubmed]
  8. Expression of inhibin beta A and beta B, follistatin and activin-A receptor messenger ribonucleic acids in the rat seminiferous epithelium. Kaipia, A., Penttilä, T.L., Shimasaki, S., Ling, N., Parvinen, M., Toppari, J. Endocrinology (1992) [Pubmed]
  9. Expression of inhibin betaA, betaB and follistatin mRNAs in the carbon tetrachloride induced rat liver regeneration model. Kobayashi, T., Niimi, S., Hashimoto, O., Hayakawa, T. Biol. Pharm. Bull. (2000) [Pubmed]
  10. Identification of a nuclear localization signal in activin/inhibin betaA subunit; intranuclear betaA in rat spermatogenic cells. Bläuer, M., Husgafvel, S., Syvälä, H., Tuohimaa, P., Ylikomi, T. Biol. Reprod. (1999) [Pubmed]
  11. Peritubular myoid cells from immature rat testes secrete activin-A and express activin receptor type II in vitro. de Winter, J.P., Vanderstichele, H.M., Verhoeven, G., Timmerman, M.A., Wesseling, J.G., de Jong, F.H. Endocrinology (1994) [Pubmed]
  12. Inhibin subunit gene expression and distribution in the ovaries of immature, young adult, middle-aged, and old female rats. Jih, M.H., Lu, J.K., Wan, Y.J., Wu, T.C. Endocrinology (1993) [Pubmed]
  13. Direct effects of estradiol and tamoxifen on gene expressions of inhibit alpha- and beta A-subunits in rat granulosa cells in vitro. Tate, S., Suganuma, N., Furuhashi, M., Ando, T., Asada, Y., Kondo, I., Kikkawa, F., Tomoda, Y. Endocr. J. (1996) [Pubmed]
  14. The pattern of inhibin/activin alpha- and betaB-subunit messenger ribonucleic acid expression in rat testis after selective Leydig cell destruction by ethylene dimethane sulfonate. Tena-Sempere, M., Kero, J., Rannikko, A., Yan, W., Huhtaniemi, I. Endocrinology (1999) [Pubmed]
  15. Sex difference in the action of activin-A on cell proliferation of differentiating rat gonad. Kaipia, A., Toppari, J., Huhtaniemi, I., Paranko, J. Endocrinology (1994) [Pubmed]
  16. Central activin administration modulates corticotropin-releasing hormone and adrenocorticotropin secretion. Plotsky, P.M., Kjaer, A., Sutton, S.W., Sawchenko, P.E., Vale, W. Endocrinology (1991) [Pubmed]
  17. Inhibin: studies of stored and secreted forms by biosynthetic labeling and immunodetection in cultured rat granulosa cells. Bicsak, T.A., Cajander, S.B., Vale, W., Hsueh, A.J. Endocrinology (1988) [Pubmed]
WikiGenes - Universities