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Gene Review

ste11  -  transcription factor Ste11

Schizosaccharomyces pombe 972h-

Synonyms: aff1, stex
 
 
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Disease relevance of ste11

  • Cells in which the rst2 gene was disrupted expressed ste11 poorly and were sterile, and this sterility could be suppressed by artificial expression of ste11 [1].
 

High impact information on ste11

  • Expression of ste11 is essential for induction of sexual development, and its ectopic expression stimulates uncontrolled mating and sporulation [2].
  • Constitutive activation of the fission yeast pheromone-responsive pathway induces ectopic meiosis and reveals ste11 as a mitogen-activated protein kinase target [3].
  • Protein kinase A (PKAi a cyclic AMP-dependent protein kinase) negatively regulates sexual development and gluconeogenesis in fission yeast by suppressing the transcription of ste11 required for the former and the transcription of fbp1 required for the latter [4].
  • Furthermore, we showed negative regulation of Byr2 by Rad25, by monitoring the mRNA level of mam2, which is regulated by both the Ras1/MAPK pathway and ste11, in various combinations of mutants [5].
  • Here we show that Rst2p, a zinc finger protein that can bind to the upstream region of ste11 and fbp1 via the STREP motif, mediates the activity of PKA to transcription of these genes [4].
 

Biological context of ste11

  • A complete Ste11p-binding motif (TR box) found in the promoter region was necessary for the full expression of ste11, suggesting that Ste11p is involved in the activation of ste11 [1].
  • We conclude that transcription of ste11 is under autoregulation in addition to control through the PKA-Rst2p pathway [1].
  • A new gene, aff1, whose defective allele suppresses the pat1-114-provoked haploid sporulation and arrest of vegetative growth is also described [6].
  • No sexual activities were detected in ste11 strains (previously referred to as aff1 or steX, which we show are allelic), whilst the production of M factor was unaffected by ste1 to ste10 mutations [7].
 

Associations of ste11 with chemical compounds

 

Regulatory relationships of ste11

 

Other interactions of ste11

  • Although expression of ste11 is regulated primarily by the cAMP cascade, genetic analysis indicated that this cascade and pac2 can partially compensate for each other in the regulation of sexual development, and that neither of them is epistatic over the other [9].

References

  1. A zinc-finger protein, Rst2p, regulates transcription of the fission yeast ste11(+) gene, which encodes a pivotal transcription factor for sexual development. Kunitomo, H., Higuchi, T., Iino, Y., Yamamoto, M. Mol. Biol. Cell (2000) [Pubmed]
  2. Schizosaccharomyces pombe ste11+ encodes a transcription factor with an HMG motif that is a critical regulator of sexual development. Sugimoto, A., Iino, Y., Maeda, T., Watanabe, Y., Yamamoto, M. Genes Dev. (1991) [Pubmed]
  3. Constitutive activation of the fission yeast pheromone-responsive pathway induces ectopic meiosis and reveals ste11 as a mitogen-activated protein kinase target. Kjaerulff, S., Lautrup-Larsen, I., Truelsen, S., Pedersen, M., Nielsen, O. Mol. Cell. Biol. (2005) [Pubmed]
  4. Protein kinase A regulates sexual development and gluconeogenesis through phosphorylation of the Zn finger transcriptional activator Rst2p in fission yeast. Higuchi, T., Watanabe, Y., Yamamoto, M. Mol. Cell. Biol. (2002) [Pubmed]
  5. The 14-3-3 proteins Rad24 and Rad25 negatively regulate Byr2 by affecting its localization in Schizosaccharomyces pombe. Ozoe, F., Kurokawa, R., Kobayashi, Y., Jeong, H.T., Tanaka, K., Sen, K., Nakagawa, T., Matsuda, H., Kawamukai, M. Mol. Cell. Biol. (2002) [Pubmed]
  6. The role of sterility genes (ste and aff) in the initiation of sexual development in Schizosaccharomyces pombe. Sipiczki, M. Mol. Gen. Genet. (1988) [Pubmed]
  7. Pheromone production and response in sterile mutants of fission yeast. Leupold, U., Sipiczki, M., Egel, R. Curr. Genet. (1991) [Pubmed]
  8. Methionine induces sexual development in the fission yeast Schizosaccharomyces pombe via an ste11-dependent signalling pathway. Schweingruber, A.M., Hilti, N., Edenharter, E., Schweingruber, M.E. J. Bacteriol. (1998) [Pubmed]
  9. Schizosaccharomyces pombe pac2+ controls the onset of sexual development via a pathway independent of the cAMP cascade. Kunitomo, H., Sugimoto, A., Wilkinson, C.R., Yamamoto, M. Curr. Genet. (1995) [Pubmed]
 
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