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MeSH Review

Zona Fasciculata

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Disease relevance of Zona Fasciculata


High impact information on Zona Fasciculata


Chemical compound and disease context of Zona Fasciculata


Biological context of Zona Fasciculata


Anatomical context of Zona Fasciculata


Associations of Zona Fasciculata with chemical compounds


Gene context of Zona Fasciculata

  • Inhibitory adenylyl cyclase 3 antibodies interfered with ACTH action only in the zona fasciculata [31].
  • In adrenal fasciculata cells, the glucocorticoid secretion is under the control of ACTH, which binds specifically MC2-R, the only functional melanocortin receptor described in these cells to date [32].
  • TGF-alpha expression was observed in the cells with increased steroidogenesis, including compact tumor cells and zona fasciculata cells with lipid depletion, but did not necessarily correlate with production sites of any specific steroid hormone [33].
  • Raised plasma and urinary levels of 11-deoxycortisol suggest that there is relative inefficiency of 11beta-hydroxylation in the zona fasciculata; the P450 enzyme responsible for this step is encoded by the gene CYP11B1, which is highly homologous with and adjacent to CYP11B2 [34].
  • The levels of expression of each isoform were similar between the two adrenocortical zones, except for adenylyl cyclase 5/6, which had a lower level of expression in the zona fasciculata [31].

Analytical, diagnostic and therapeutic context of Zona Fasciculata


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  17. Development of adrenal zonation in fetal rats defined by expression of aldosterone synthase and 11beta-hydroxylase. Wotus, C., Levay-Young, B.K., Rogers, L.M., Gomez-Sanchez, C.E., Engeland, W.C. Endocrinology (1998) [Pubmed]
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  19. Angiotensin-II-induced expression of proto-oncogene (c-fos, jun-B and c-jun) mRNA in bovine adrenocortical fasciculata cells (BAC) is mediated by AT-1 receptors. Viard, I., Jaillard, C., Ouali, R., Saez, J.M. FEBS Lett. (1992) [Pubmed]
  20. Divergent differentiation of rat adrenocortical cells is associated with an interruption of angiotensin II-mediated signal transduction. Roskelley, C.D., Baimbridge, K.G., Leung, P.C., Auersperg, N. Mol. Cell. Endocrinol. (1992) [Pubmed]
  21. Involvement of an AP-1 complex in zone-specific expression of the CYP11B1 gene in the rat adrenal cortex. Mukai, K., Mitani, F., Shimada, H., Ishimura, Y. Mol. Cell. Biol. (1995) [Pubmed]
  22. Tissue-specific expression of rat IL-18 gene and response to adrenocorticotropic hormone treatment. Sugama, S., Kim, Y., Baker, H., Tinti, C., Kim, H., Joh, T.H., Conti, B. J. Immunol. (2000) [Pubmed]
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  25. Angiotensin-II inhibits Na+/K+ pump in rat adrenal glomerulosa cells: possible contribution to stimulation of aldosterone production. Hajnóczky, G., Csordás, G., Hunyady, L., Kalapos, M.P., Balla, T., Enyedi, P., Spät, A. Endocrinology (1992) [Pubmed]
  26. Gonadal luteinizing hormone receptors and adenylate cyclase: transfer of functional ovarian luteinizing hormone receptors to adrenal fasciculata cells. Dufau, M.L., Hayashi, K., Sala, G., Baukal, A., Catt, K.J. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
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  28. P450c11B3 mRNA, transcribed from a third P450c11 gene, is expressed in a tissue-specific, developmentally, and hormonally regulated fashion in the rodent adrenal and encodes a protein with both 11-hydroxylase and 18-hydroxylase activities. Mellon, S.H., Bair, S.R., Monis, H. J. Biol. Chem. (1995) [Pubmed]
  29. The product of the CYP11B2 gene is required for aldosterone biosynthesis in the human adrenal cortex. Curnow, K.M., Tusie-Luna, M.T., Pascoe, L., Natarajan, R., Gu, J.L., Nadler, J.L., White, P.C. Mol. Endocrinol. (1991) [Pubmed]
  30. Zona fasciculata-like cells determine the response of plasma aldosterone to metoclopramide and aldosterone synthase messenger ribonucleic acid level in aldosterone-producing adenoma. Wu, K.D., Chen, Y.M., Chu, J.S., Hung, K.Y., Hsieh, T.S., Hsieh, B.S. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
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  32. Agouti-related protein antagonizes glucocorticoid production induced through melanocortin 4 receptor activation in bovine adrenal cells: a possible autocrine control. Doghman, M., Delagrange, P., Blondet, A., Berthelon, M.C., Durand, P., Naville, D., Bégeot, M. Endocrinology (2004) [Pubmed]
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