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Gene Review

luxS  -  S-ribosylhomocysteinase

Porphyromonas gingivalis W83

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Disease relevance of luxS

  • In contrast, no increase in leukotoxin expression occurred when cells were exposed to sterile medium or to conditioned broth from E. coli AIS(-), a recombinant strain in which luxS was insertionally inactivated [1].
  • The periodontopathogen Porphyromonas gingivalis possesses a luxS gene homologue that may encode a quorum-sensing system [2].
  • Here, we report that the periodontal pathogen Actinobacillus actinomycetemcomitans expresses a homolog of V. harveyi luxS and secretes an AI-2-like signal [1].
  • The luxS gene of quorum-sensing Vibrio harveyi is required for type 2 autoinducer production [3].
  • In the present study, we identified luxS, a gene responsible for the synthesis of AI-2, in Streptococcus gordonii, a major component of the dental plaque biofilm [4].

High impact information on luxS

  • Mutation of the GppX two-component signal transduction pathway caused an increase in expression of luxS along with tlr and lower levels of message for hmuR [5].
  • Compared to the parental strain, the luxS mutant showed reduced levels of transcription of genes coding for the TonB-linked hemin binding protein Tlr and the lysine-specific protease Kgp, which can degrade host heme-containing proteins [5].
  • In order to identify genes of P. gingivalis that are regulated by luxS, gene expression analysis was done using microarrays and RNA samples from the W83 wild-type strain and an isogenic luxS mutant, LY2001 [2].
  • Biofilm formation by the luxS mutant in 0.5% sucrose defined medium was found to be markedly attenuated compared to the wild type [6].
  • An isogenic mutant of S. gordonii, generated by insertional inactivation of the luxS gene, was unaffected in growth and in its ability to form biofilms on polystyrene surfaces [4].

Biological context of luxS

  • Conditioned medium from a late-log-phase P. gingivalis culture induced the luciferase operon of V. harveyi, but that from a luxS insertional mutant did not [3].
  • In P. gingivalis, the expression of luxS mRNA was environmentally controlled and varied according to the cell density and the osmolarity of the culture medium [3].
  • In addition, differential display PCR showed that the inactivation of P. gingivalis luxS resulted in up-regulation of a hemin acquisition protein and an arginine-specific protease and reduced expression of a hemin-regulated protein, a TonB homologue, and an excinuclease [3].

Associations of luxS with chemical compounds

  • Differential display PCR demonstrated that the inactivation of S. gordonii luxS downregulated the expression of a number of genes, including gtfG, encoding glucosyltransferase; fruA, encoding extracellular exo-beta-D-fructosidase; and lacD encoding tagatose 1,6-diphosphate aldolase [4].

Other interactions of luxS

  • Moreover, expression of hmuR was repressed, and expression of tlr stimulated, when the luxS mutant was incubated with AI-2 partially purified from the culture supernatant of wild-type cells [5].

Analytical, diagnostic and therapeutic context of luxS


  1. Intra- and interspecies regulation of gene expression by Actinobacillus actinomycetemcomitans LuxS. Fong, K.P., Chung, W.O., Lamont, R.J., Demuth, D.R. Infect. Immun. (2001) [Pubmed]
  2. Microarray analysis of quorum-sensing-regulated genes in Porphyromonas gingivalis. Yuan, L., Hillman, J.D., Progulske-Fox, A. Infect. Immun. (2005) [Pubmed]
  3. Signaling system in Porphyromonas gingivalis based on a LuxS protein. Chung, W.O., Park, Y., Lamont, R.J., McNab, R., Barbieri, B., Demuth, D.R. J. Bacteriol. (2001) [Pubmed]
  4. LuxS-based signaling in Streptococcus gordonii: autoinducer 2 controls carbohydrate metabolism and biofilm formation with Porphyromonas gingivalis. McNab, R., Ford, S.K., El-Sabaeny, A., Barbieri, B., Cook, G.S., Lamont, R.J. J. Bacteriol. (2003) [Pubmed]
  5. LuxS involvement in the regulation of genes coding for hemin and iron acquisition systems in Porphyromonas gingivalis. James, C.E., Hasegawa, Y., Park, Y., Yeung, V., Tribble, G.D., Kuboniwa, M., Demuth, D.R., Lamont, R.J. Infect. Immun. (2006) [Pubmed]
  6. LuxS-based signaling affects Streptococcus mutans biofilm formation. Yoshida, A., Ansai, T., Takehara, T., Kuramitsu, H.K. Appl. Environ. Microbiol. (2005) [Pubmed]
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