Disease relevance of SOSTDC1

• We observed four hepatocellular carcinomas without hypervascularity on DSA or USAG, which stained positively with QB antibody; these hepatocellular carcinomas had fatty metamorphosis [1].

High impact information on SOSTDC1

• The CAN family can be divided further into four subgroups based on a conserved arrangement of additional cysteine residues-gremlin and PRDC, cerberus and coco, and DAN, together with USAG-1 and sclerostin [2].
• We analyzed the regulation and function of ectodin in tooth germs [3].
• Recombinant ectodin protein produced in cultured cells was efficiently secreted as a antagonist [3].
• Ectodin is intensely expressed in developing ectodermal organs, including teeth, vibrissae, and hair follicles [3].
• Renal BMP signaling, assessed by phosphorylation of Smad proteins, is significantly enhanced in USAG-1(-/-) mice during renal injury, indicating that the preservation of renal function is attributed to enhancement of endogenous BMP-7 signaling [4].

Chemical compound and disease context of SOSTDC1

• METHODS: Hepatocellular carcinomas were evaluated by digital subtraction angiography (DSA), ultrasound angiography with intraarterial CO2 microbubbles (USAG), and computed tomography during arterial portography (CTAP) [1].

Biological context of SOSTDC1

• In the early stage of mouse embryogenesis, USAG-1 is expressed in the first and second branchial arches and in metanephros, while in later stages the expression is confined to renal tubules and ameloblasts of teeth [5].

Anatomical context of SOSTDC1

• Uterine sensitization-associated gene-1 (USAG-1) was previously reported as a gene of unknown function, preferentially expressed in sensitized endometrium of the rat uterus [5].

Associations of SOSTDC1 with chemical compounds

• Hepatic angiography (digital subtraction angiography; DSA and ultrasound angiography with intraarterial CO2 microbubbles; USAG) was performed before treatment in all cases, and the vascularity of the tumor was clinically evaluated [6].

Analytical, diagnostic and therapeutic context of SOSTDC1

• Selective hepatic intraarterial digital subtraction angiography (DSA), ultrasonographic angiography with carbon dioxide microbubbles (USAG), and computed tomography during arterial portography (CTAP) were performed to evaluate the hemodynamics of hepatic nodules [7].

References