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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Vibrissae

 
 
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Disease relevance of Vibrissae

  • Nevertheless, the highest degrees and ratios of metaplasia were only obtained after treatment with the CD367 RAR panagonist, or with either Ro40-6055 or CD437 at a concentration sufficient to allow the activation of the three RAR, suggesting that RARbeta activation is required for a metaplasia of all vibrissae [1].
  • Despite the nearly normal mapping of V ganglion cell axons onto the vibrissae follicles and brainstem, staining for either cytochrome oxidase (CO) or parvalbumin failed to reveal vibrissae-related patterns in PrV, SpI, or the magnocellular portion of V subnucleus caudalis in these animals [2].
 

Psychiatry related information on Vibrissae

 

High impact information on Vibrissae

  • Hoxc13 is also expressed in vibrissae, in the filiform papillae of the tongue, and in hair follicles throughout the body; a pattern that apparently violates spatial colinearity [8].
  • Mineralization of vibrissae was noted as early as 5 weeks of age and was progressive with age in Abcc6(-/-) mice but was not observed in Abcc6(+/-) or Abcc6(+/+) mice up to 2 years of age [9].
  • Particularly striking was the mineralization of vibrissae, as confirmed by von Kossa and alizarin red stains [9].
  • Here we report that heterozygous mice with deletions of the TRPS1 GATA domain (TRPS1(+/Deltagt)) display facial anomalies that overlap with findings for TRPS, whereas TRPS1(Deltagt/Deltagt) mice additionally reveal a complete absence of vibrissae [10].
  • Mf2 (mesoderm/mesenchyme forkhead 2) encodes a forkhead/winged helix transcription factor expressed in numerous tissues of the mouse embryo, including paraxial mesoderm, somites, branchial arches, vibrissae, developing central nervous system, and developing kidney [11].
 

Biological context of Vibrissae

  • The compound muscle action potential (MAP) of the vibrissae muscle began to reappear 4 weeks after the first BTX injection [12].
  • p63 protein is essential for the embryonic development of vibrissae and teeth [13].
  • Reconstitution of scid mice with whole splenocytes resulted in functional recovery times similar to wild-type, with eye blink reflex recovery and vibrissae movement being 10.5+/-0.3 and 10.0+/-0.0 days, respectively [14].
  • Neonatal transection of the infraorbital nerve (ION; the trigeminal, V, branch that supplies the mystacial vibrissae follicles) results in an upregulation of galanin in the central arbors of primary afferent axons [15].
  • Taken together with the demonstration that acute injection of this dose of mAMPH induces the immediate early gene zif/268 and Fos protein in barrel cortex, these data suggest that the prolonged behavioral activity involving the vibrissae contributes to the mAMPH-induced damage to S1 neurons [16].
 

Anatomical context of Vibrissae

 

Associations of Vibrissae with chemical compounds

  • The 85% depletion of 5-HT did not alter the somatotopic organization of thalamocortical afferents in animals killed on P-6 or P > 60, but it did cause 30.5 +/- 7.3% and 19.1 +/- 3.7% reductions in the cross-sectional areas of the patches of thalamocortical afferents corresponding to the long mystacial vibrissae (p < 0.05) [22].
  • The cortical representation of a trained row of vibrissae was visualized with 2-deoxyglucose (2DG) functional brain mapping 1 day after the completion of the conditioning procedure [23].
  • The partial blockade of NMDA receptors within the barrel cortex reduced (by half) the expansion of the cortical representation of a trained row of vibrissae as compared to the enlargement of the cortical representation of a trained row found in untreated (60%) and Elvax-PBS implanted (47%) mice [23].
  • Vibrissae stimulation failed to increase glucose utilization significantly in cortical areas remote from the infarct [24].
  • As a nociceptive stimulus, we injected formalin into the left mystacial vibrissae, assessed behaviour for 45 min and sacrificed the animals 45 min later [25].
 

Gene context of Vibrissae

  • We show that radioactively labelled exogenous GDNF is retrogradely transported from neonatal teeth and vibrissae to the trigeminal neurons, indicating that GDNF acts as a classical neurotrophic factor in the trigeminal system [26].
  • Hoxa4 expression is first seen in E13.5 vibrissae throughout the follicle placode [27].
  • Outside the nervous system, Jag2 is expressed in the developing vibrissae follicles, tooth buds, thymus, submandibular gland and stomach [28].
  • Ret mRNA was also found in several sensory systems, in ganglia, and in nonneuronal tissues such as teeth and vibrissae [29].
  • To determine whether the decreased CMR(glc) in mutant TR alpha 1(PV/+) mice reflected lesser synaptic density or reduced functional activity in existing synapses, we stimulated vibrissae unilaterally and measured CMR(glc) bilaterally in four stations of the whisker-to-barrel cortex pathway [30].
 

Analytical, diagnostic and therapeutic context of Vibrissae

References

  1. Both retinoic acid receptors alpha (RARalpha) and gamma (RARgamma) are able to initiate mouse upper-lip skin glandular metaplasia. Blanchet, S., Favier, B., Chevalier, G., Kastner, P., Michaille, J.J., Chambon, P., Dhouailly, D. J. Invest. Dermatol. (1998) [Pubmed]
  2. Long-term effects of neonatal axoplasmic transport attenuation on the organization of the rat's trigeminal system. Chiaia, N.L., Bennett-Clarke, C.A., Crissman, R.S., Zhang, S., Rhoades, R.W. J. Comp. Neurol. (1997) [Pubmed]
  3. Short-lasting classical conditioning induces reversible changes of representational maps of vibrissae in mouse SI cortex--a 2DG study. Siucinska, E., Kossut, M. Cereb. Cortex (1996) [Pubmed]
  4. Sleep modifies glutamate decarboxylase mRNA within the barrel cortex of rats after a mystacial whisker trim. Churchill, L., Taishi, P., Guan, Z., Chen, L., Fang, J., Krueger, J.M. Sleep. (2001) [Pubmed]
  5. Expression of c-Fos, Fos B, Jun B, and Zif268 transcription factor proteins in rat barrel cortex following apomorphine-evoked whisking behavior. Filipkowski, R.K., Rydz, M., Kaczmarek, L. Neuroscience (2001) [Pubmed]
  6. C-fiber depletion alters response properties of neurons in trigeminal nucleus principalis. Kwan, C.L., Demaro, J.A., Hu, J.W., Jacquin, M.F., Sessle, B.J. J. Neurophysiol. (1999) [Pubmed]
  7. Reduction of GABAA receptor binding of [3H]muscimol in the barrel field of mice after peripheral denervation: transient and long-lasting effects. Skangiel-Kramska, J., Głazewski, S., Jabłońska, B., Siucińska, E., Kossut, M. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1994) [Pubmed]
  8. Hoxc13 mutant mice lack external hair. Godwin, A.R., Capecchi, M.R. Genes Dev. (1998) [Pubmed]
  9. Targeted ablation of the abcc6 gene results in ectopic mineralization of connective tissues. Klement, J.F., Matsuzaki, Y., Jiang, Q.J., Terlizzi, J., Choi, H.Y., Fujimoto, N., Li, K., Pulkkinen, L., Birk, D.E., Sundberg, J.P., Uitto, J. Mol. Cell. Biol. (2005) [Pubmed]
  10. Deletion of the GATA domain of TRPS1 causes an absence of facial hair and provides new insights into the bone disorder in inherited tricho-rhino-phalangeal syndromes. Malik, T.H., Von Stechow, D., Bronson, R.T., Shivdasani, R.A. Mol. Cell. Biol. (2002) [Pubmed]
  11. Minimal phenotype of mice homozygous for a null mutation in the forkhead/winged helix gene, Mf2. Kume, T., Deng, K., Hogan, B.L. Mol. Cell. Biol. (2000) [Pubmed]
  12. Time course for the reappearance of vibrissal motor representation following botulinum toxin injection into the vibrissal pad of the adult rat. Franchi, G., Veronesi, C. Eur. J. Neurosci. (2004) [Pubmed]
  13. p63 protein is essential for the embryonic development of vibrissae and teeth. Rufini, A., Weil, M., McKeon, F., Barlattani, A., Melino, G., Candi, E. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  14. Functional recovery after facial nerve crush is delayed in severe combined immunodeficient mice. Serpe, C.J., Tetzlaff, J.E., Coers, S., Sanders, V.M., Jones, K.J. Brain Behav. Immun. (2002) [Pubmed]
  15. Synaptic organization of damaged infraorbital nerve axons in perinatal rats: demonstration by galanin immunocytochemistry. Crissman, R.S., Zheng, L., Chiaia, N.L., Rhoades, R.W. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1996) [Pubmed]
  16. Effects of vibrissae removal on methamphetamine-induced damage to rat somatosensory cortical neurons. O'Dell, S.J., Marshall, J.F. Synapse (2002) [Pubmed]
  17. Overexpression of mouse follistatin causes reproductive defects in transgenic mice. Guo, Q., Kumar, T.R., Woodruff, T., Hadsell, L.A., DeMayo, F.J., Matzuk, M.M. Mol. Endocrinol. (1998) [Pubmed]
  18. Interaction of the MAGUK family member Acvrinp1 and the cytoplasmic domain of the Notch ligand Delta1. Pfister, S., Przemeck, G.K., Gerber, J.K., Beckers, J., Adamski, J., Hrabé de Angelis, M. J. Mol. Biol. (2003) [Pubmed]
  19. Proceedings: The relative sensitivity of glutamate and aspartate of cells in the ventrobasal thalamus of the rat which respond to movement of the vibrissae. Gent, J.P., Wolstencroft, J.H. J. Physiol. (Lond.) (1976) [Pubmed]
  20. Effect of activity blockade on changes in vibrissae-related patterns in the rat's primary somatosensory cortex induced by serotonin depletion. Rhoades, R.W., Chiaia, N.L., Lane, R.D., Bennett-Clarke, C.A. J. Comp. Neurol. (1998) [Pubmed]
  21. Common fur and mystacial vibrissae parallel sensory pathways: 14 C 2-deoxyglucose and WGA-HRP studies in the rat. Sharp, F.R., Gonzalez, M.F., Morgan, C.W., Morton, M.T., Sharp, J.W. J. Comp. Neurol. (1988) [Pubmed]
  22. Effect of serotonin depletion on vibrissa-related patterns of thalamic afferents in the rat's somatosensory cortex. Bennett-Clarke, C.A., Leslie, M.J., Lane, R.D., Rhoades, R.W. J. Neurosci. (1994) [Pubmed]
  23. Partial blocking of NMDA receptors reduces plastic changes induced by short-lasting classical conditioning in the SI barrel cortex of adult mice. Jablonska, B., Gierdalski, M., Kossut, M., Skangiel-Kramska, J. Cereb. Cortex (1999) [Pubmed]
  24. Influence of amphetamine treatment on somatosensory function of the normal and infarcted rat brain. Dietrich, W.D., Alonso, O., Busto, R., Watson, B.D., Loor, Y., Ginsberg, M.D. Stroke (1990) [Pubmed]
  25. Vagus nerve stimulation in awake rats reduces formalin-induced nociceptive behaviour and fos-immunoreactivity in trigeminal nucleus caudalis. Bohotin, C., Scholsem, M., Multon, S., Martin, D., Bohotin, V., Schoenen, J. Pain (2003) [Pubmed]
  26. Dental pulp cells provide neurotrophic support for dopaminergic neurons and differentiate into neurons in vitro; implications for tissue engineering and repair in the nervous system. Nosrat, I.V., Smith, C.A., Mullally, P., Olson, L., Nosrat, C.A. Eur. J. Neurosci. (2004) [Pubmed]
  27. Hoxa4 expression in developing mouse hair follicles and skin. Packer, A.I., Jane-Wit, D., McLean, L., Panteleyev, A.A., Christiano, A.M., Wolgemuth, D.J. Mech. Dev. (2000) [Pubmed]
  28. JAGGED2: a putative Notch ligand expressed in the apical ectodermal ridge and in sites of epithelial-mesenchymal interactions. Valsecchi, C., Ghezzi, C., Ballabio, A., Rugarli, E.I. Mech. Dev. (1997) [Pubmed]
  29. Cellular and developmental patterns of expression of Ret and glial cell line-derived neurotrophic factor receptor alpha mRNAs. Nosrat, C.A., Tomac, A., Hoffer, B.J., Olson, L. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1997) [Pubmed]
  30. Functional activation of cerebral metabolism in mice with mutated thyroid hormone nuclear receptors. Esaki, T., Suzuki, H., Cook, M., Shimoji, K., Cheng, S.Y., Sokoloff, L., Nunez, J. Endocrinology (2003) [Pubmed]
  31. Rapid regulation of GAD67 mRNA and protein level in cortical neurons after sensory learning. Gierdalski, M., Jablonska, B., Siucinska, E., Lech, M., Skibinska, A., Kossut, M. Cereb. Cortex (2001) [Pubmed]
  32. Evidence for survival of the central arbors of trigeminal primary afferents after peripheral neonatal axotomy: experiments with galanin immunocytochemistry and Di-I labelling. White, F.A., Hoeflinger, B.F., Chiaia, N.L., Bennett-Clarke, C.A., Crissman, R.S., Rhoades, R.W. J. Comp. Neurol. (1994) [Pubmed]
  33. Response properties of vibrissa units in rat SI somatosensory neocortex. Simons, D.J. J. Neurophysiol. (1978) [Pubmed]
  34. Inhibition of thalamic ventrobasal complex neurons by glutamate infusion into the thalamic reticular nucleus in rats. Mushiake, S., Shosaku, A., Kayama, Y. J. Neurosci. Res. (1984) [Pubmed]
  35. Effect of castration and testosterone propionate on mouse vibrissae. Ibrahim, L., Wright, E.A. Br. J. Dermatol. (1983) [Pubmed]
 
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