Gene Review:
IRF9 - interferon regulatory factor 9
Homo sapiens
Synonyms:
IFN-alpha-responsive transcription factor subunit, IRF-9, ISGF-3 gamma, ISGF3, ISGF3 p48 subunit, ...
- A hybrid IRF9-STAT2 protein recapitulates interferon-stimulated gene expression and antiviral response. Kraus, T.A., Lau, J.F., Parisien, J.P., Horvath, C.M. J. Biol. Chem. (2003)
- Retinoic acid induces signal transducer and activator of transcription (STAT) 1, STAT2, and p48 expression in myeloid leukemia cells and enhances their responsiveness to interferons. Matikainen, S., Ronni, T., Lehtonen, A., Sareneva, T., Melén, K., Nordling, S., Levy, D.E., Julkunen, I. Cell Growth Differ. (1997)
- Overexpression of IRF9 confers resistance to antimicrotubule agents in breast cancer cells. Luker, K.E., Pica, C.M., Schreiber, R.D., Piwnica-Worms, D. Cancer Res. (2001)
- Type I interferon induces inhibitory 16-kD CCAAT/ enhancer binding protein (C/EBP)beta, repressing the HIV-1 long terminal repeat in macrophages: pulmonary tuberculosis alters C/EBP expression, enhancing HIV-1 replication. Honda, Y., Rogers, L., Nakata, K., Zhao, B.Y., Pine, R., Nakai, Y., Kurosu, K., Rom, W.N., Weiden, M. J. Exp. Med. (1998)
- A transcription factor with SH2 and SH3 domains is directly activated by an interferon alpha-induced cytoplasmic protein tyrosine kinase(s). Fu, X.Y. Cell (1992)
- Two interferon-induced proteins are involved in the protein kinase complex dependent on double-stranded RNA. Galabru, J., Hovanessian, A.G. Cell (1985)
- A retinoblastoma-binding protein related to a negative regulator of Ras in yeast. Qian, Y.W., Wang, Y.C., Hollingsworth, R.E., Jones, D., Ling, N., Lee, E.Y. Nature (1993)
- Activation of transcription factors by interferon-alpha in a cell-free system. David, M., Larner, A.C. Science (1992)
- Role of metazoan mediator proteins in interferon-responsive transcription. Lau, J.F., Nusinzon, I., Burakov, D., Freedman, L.P., Horvath, C.M. Mol. Cell. Biol. (2003)
- Functional relevance of the conserved DNA-binding domain of STAT2. Brierley, M.M., Fish, E.N. J. Biol. Chem. (2005)
- Organization of the genes encoding the human proteasome activators PA28alpha and beta. McCusker, D., Wilson, M., Trowsdale, J. Immunogenetics (1999)
- Essential and non-redundant roles of p48 (ISGF3 gamma) and IRF-1 in both type I and type II interferon responses, as revealed by gene targeting studies. Kimura, T., Kadokawa, Y., Harada, H., Matsumoto, M., Sato, M., Kashiwazaki, Y., Tarutani, M., Tan, R.S., Takasugi, T., Matsuyama, T., Mak, T.W., Noguchi, S., Taniguchi, T. Genes Cells (1996)
- Defective induction of the transcription factor interferon-stimulated gene factor-3 and interferon alpha insensitivity in human trophoblast cells. Cross, J.C., Lam, S., Yagel, S., Werb, Z. Biol. Reprod. (1999)
- Synergistic interaction between interferon-alpha and interferon-gamma through induced synthesis of one subunit of the transcription factor ISGF3. Levy, D.E., Lew, D.J., Decker, T., Kessler, D.S., Darnell, J.E. EMBO J. (1990)
- Function of Stat2 protein in transcriptional activation by alpha interferon. Qureshi, S.A., Leung, S., Kerr, I.M., Stark, G.R., Darnell, J.E. Mol. Cell. Biol. (1996)
- Gene induction by interferons: functional complementation between trans-acting factors induced by alpha interferon and gamma interferon. Bandyopadhyay, S.K., Kalvakolanu, D.V., Sen, G.C. Mol. Cell. Biol. (1990)
- Protein kinase activity required for an early step in interferon-alpha signaling. Kessler, D.S., Levy, D.E. J. Biol. Chem. (1991)
- Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA. Bluyssen, H.A., Levy, D.E. J. Biol. Chem. (1997)
- Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins. Veals, S.A., Schindler, C., Leonard, D., Fu, X.Y., Aebersold, R., Darnell, J.E., Levy, D.E. Mol. Cell. Biol. (1992)
- Combinatorial association and abundance of components of interferon-stimulated gene factor 3 dictate the selectivity of interferon responses. Bluyssen, H.A., Muzaffar, R., Vlieststra, R.J., van der Made, A.C., Leung, S., Stark, G.R., Kerr, I.M., Trapman, J., Levy, D.E. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Interferon regulatory factor subcellular localization is determined by a bipartite nuclear localization signal in the DNA-binding domain and interaction with cytoplasmic retention factors. Lau, J.F., Parisien, J.P., Horvath, C.M. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Differentiation of monocytes to macrophages switches the Mycobacterium tuberculosis effect on HIV-1 replication from stimulation to inhibition: modulation of interferon response and CCAAT/enhancer binding protein beta expression. Weiden, M., Tanaka, N., Qiao, Y., Zhao, B.Y., Honda, Y., Nakata, K., Canova, A., Levy, D.E., Rom, W.N., Pine, R. J. Immunol. (2000)
- Roles of Stat1, Stat2, and interferon regulatory factor-9 (IRF-9) in interferon tau regulation of IRF-1. Stewart, M.D., Choi, Y., Johnson, G.A., Yu-Lee, L.Y., Bazer, F.W., Spencer, T.E. Biol. Reprod. (2002)
- A non-classical ISRE/ISGF3 pathway mediates induction of RANTES gene transcription by type I IFNs. Cremer, I., Ghysdael, J., Vieillard, V. FEBS Lett. (2002)
- Interaction of retinoic acid and interferon in renal cancer cell lines. Nanus, D.M., Geng, Y., Shen, R., Lai, H.K., Pfeffer, S.R., Pfeffer, L.M. J. Interferon Cytokine Res. (2000)
- Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3. Martinez-Moczygemba, M., Gutch, M.J., French, D.L., Reich, N.C. J. Biol. Chem. (1997)
- Histone deacetylase activity is required to recruit RNA polymerase II to the promoters of selected interferon-stimulated early response genes. Sakamoto, S., Potla, R., Larner, A.C. J. Biol. Chem. (2004)
- Interferon (IFN) beta acts downstream of IFN-gamma-induced class II transactivator messenger RNA accumulation to block major histocompatibility complex class II gene expression and requires the 48-kD DNA-binding protein, ISGF3-gamma. Lu, H.T., Riley, J.L., Babcock, G.T., Huston, M., Stark, G.R., Boss, J.M., Ransohoff, R.M. J. Exp. Med. (1995)
- Modulation of interferon signaling in human fibroblasts by phorbol esters. Petricoin, E.F., Hackett, R.H., Akai, H., Igarashi, K., Finbloom, D.S., Larner, A.C. Mol. Cell. Biol. (1992)
- Primary leukemia cells resistant to alpha-interferon in vitro are defective in the activation of the DNA-binding factor interferon-stimulated gene factor 3. Xu, B., Grandér, D., Sangfelt, O., Einhorn, S. Blood (1994)
- The locus-specific enhancer activity of the class I major histocompatibility complex interferon-responsive element is associated with a gamma-interferon (IFN)-inducible factor distinct from STAT1alpha, p48, and IFN regulatory factor-1. Vallejo, A.N., Pease, L.R. J. Biol. Chem. (1996)
- Toll-like receptor-dependent and -independent Viperin gene expression and counter-regulation by PRDI-binding factor-1/BLIMP1. Severa, M., Coccia, E.M., Fitzgerald, K.A. J. Biol. Chem. (2006)